Enhancement of dissolution rate of valdecoxib using solid dispersions with polyethylene glycol 4000

The aim of the present study was to enhance the dissolution rate of valdecoxib using its solid dispersions (SDs) with polyethylene glycol (PEG) 4000. The phase solubility behavior of valdecoxib in the presence of various concentrations of PEG 4000 in water was obtained at 37 degrees C. The solubilit...

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Veröffentlicht in:	Drug development and industrial pharmacy 2005, Vol.31 (1), p.1-10
Hauptverfasser:	CHENGSHENG LIU, CHENGUANG LIU, DESAI, Kashappa Goud H
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biological and medical sciences Calorimetry, Differential Scanning Chemistry, Pharmaceutical Cyclooxygenase Inhibitors - chemistry Excipients General pharmacology Isoxazoles - chemistry Kinetics Mannitol Medical sciences Microscopy, Electron, Scanning Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene Glycols Povidone Solubility Spectroscopy, Fourier Transform Infrared Sulfonamides - chemistry Urea X-Ray Diffraction
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