The Relationship between Epidermal Growth Factor Receptor Mutations and Clinicopathologic Features in Non–Small Cell Lung Cancers

Purpose: Recent studies reported that clinical responsiveness to gefitinib was associated with somatic mutation of epidermal growth factor receptor ( EGFR ) gene in non–small cell lung cancers (NSCLC). Here, we investigated the relationship between EGFR mutation and clinicopathologic features. Exper...

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Veröffentlicht in:	Clinical cancer research 2005-02, Vol.11 (3), p.1167-1173
Hauptverfasser:	TOKUMO, Masaki, TOYOOKA, Shinichi, TABATA, Masahiro, UEOKA, Hiroshi, TANIMOTO, Mitsune, DATE, Hiroshi, GAZDAR, Adi F, SHIMIZU, Nobuyoshi, KIURA, Katsuyuki, SHIGEMATSU, Hisayuki, TOMII, Kunitoshi, AOE, Motoi, ICHIMURA, Kouichi, TSUDA, Toshihide, YANO, Masaaki, TSUKUDA, Kazunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Amino Acid Sequence Antineoplastic agents Antineoplastic Agents - therapeutic use Base Sequence Biological and medical sciences Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology DNA Mutational Analysis DNA, Neoplasm - chemistry DNA, Neoplasm - genetics EGFR Female gefitinib Humans lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Male Medical sciences Middle Aged Mutation Pharmacology. Drug treatments Pneumology Quinazolines - therapeutic use Receptor, Epidermal Growth Factor - genetics Sequence Homology, Amino Acid Smoking Survival Analysis Treatment Outcome Tumors of the respiratory system and mediastinum
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