Reactive oxidative metabolites are associated with atrial conduction disturbance in patients with atrial fibrillation
Background Oxidative stress is associated with atrial fibrillation (AF). However, little is known about the relationship between serum markers of oxidation and electrical activity in patients with AF. Objective The purpose of this study was to investigate the possible association between serum marke...
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| Veröffentlicht in: | Heart rhythm 2009-07, Vol.6 (7), p.935-940 |
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| creator | Shimano, Masayuki, MD, PhD Shibata, Rei, MD, PhD Inden, Yasuya, MD, PhD Yoshida, Naoki, MD Uchikawa, Tomohiro, MD Tsuji, Yukiomi, MD, PhD Murohara, Toyoaki, MD, PhD |
| description | Background Oxidative stress is associated with atrial fibrillation (AF). However, little is known about the relationship between serum markers of oxidation and electrical activity in patients with AF. Objective The purpose of this study was to investigate the possible association between serum markers of reactive oxidative metabolism and atrial remodeling in paroxysmal and persistent AF. Methods Derivatives of reactive oxidative metabolites (DROM), an index of oxidative stress, were measured in 306 consecutive patients with AF (225 paroxysmal, 81 persistent) undergoing radiofrequency (RF) catheter ablation. Filtered P-wave duration by P-wave signal-averaged ECG and levels of high-sensitivity C-reactive protein (CRP) as an inflammatory marker also were measured. Results Patients were followed up for 1.2 ± 0.8 years. DROM levels in patients with persistent AF were significantly higher than in patients with paroxysmal AF (341.6 ± 85.5 Carratelli [Carr] units vs 305.0 ± 77.7 Carr units, P |
| doi_str_mv | 10.1016/j.hrthm.2009.03.012 |
| format | Article |
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However, little is known about the relationship between serum markers of oxidation and electrical activity in patients with AF. Objective The purpose of this study was to investigate the possible association between serum markers of reactive oxidative metabolism and atrial remodeling in paroxysmal and persistent AF. Methods Derivatives of reactive oxidative metabolites (DROM), an index of oxidative stress, were measured in 306 consecutive patients with AF (225 paroxysmal, 81 persistent) undergoing radiofrequency (RF) catheter ablation. Filtered P-wave duration by P-wave signal-averaged ECG and levels of high-sensitivity C-reactive protein (CRP) as an inflammatory marker also were measured. Results Patients were followed up for 1.2 ± 0.8 years. DROM levels in patients with persistent AF were significantly higher than in patients with paroxysmal AF (341.6 ± 85.5 Carratelli [Carr] units vs 305.0 ± 77.7 Carr units, P <.001). DROM levels showed a tighter, positive correlation with filtered P-wave duration in persistent AF patients (r = 0.56, P <.001) than in all AF patients (r = 0.13, P <.05). DROM levels also showed a weaker but significant correlation with high-sensitivity CRP in patients with AF. Kaplan-Meier analysis revealed that the highest quartile of basal DROM levels exhibited a significantly higher AF recurrence rate after RF catheter ablation in patients with paroxysmal AF ( P <.01). Conclusion Serum markers of oxidative stress reflect atrial conduction disturbance and predict AF recurrence after RF catheter ablation in paroxysmal AF patients. DROM could serve as a biomarker for predicting risk of AF recurrence after RF catheter ablation.</description><identifier>ISSN: 1547-5271</identifier><identifier>EISSN: 1556-3871</identifier><identifier>DOI: 10.1016/j.hrthm.2009.03.012</identifier><identifier>PMID: 19560081</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Ablation ; Aged ; Atrial fibrillation ; Atrial Fibrillation - metabolism ; Atrial Fibrillation - physiopathology ; Biomarkers ; Cardiovascular ; Female ; Heart Atria - metabolism ; Heart Atria - physiopathology ; Heart Conduction System - metabolism ; Humans ; Male ; Middle Aged ; Oxidative Stress ; Reactive Oxygen Species - metabolism ; Remodeling ; Signal-averaged P wave</subject><ispartof>Heart rhythm, 2009-07, Vol.6 (7), p.935-940</ispartof><rights>Heart Rhythm Society</rights><rights>2009 Heart Rhythm Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-2454f9bb30e1f039153e8ddcf9ef477218d19309fbb17d7de419a96b72f9ecff3</citedby><cites>FETCH-LOGICAL-c412t-2454f9bb30e1f039153e8ddcf9ef477218d19309fbb17d7de419a96b72f9ecff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.hrthm.2009.03.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19560081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimano, Masayuki, MD, PhD</creatorcontrib><creatorcontrib>Shibata, Rei, MD, PhD</creatorcontrib><creatorcontrib>Inden, Yasuya, MD, PhD</creatorcontrib><creatorcontrib>Yoshida, Naoki, MD</creatorcontrib><creatorcontrib>Uchikawa, Tomohiro, MD</creatorcontrib><creatorcontrib>Tsuji, Yukiomi, MD, PhD</creatorcontrib><creatorcontrib>Murohara, Toyoaki, MD, PhD</creatorcontrib><title>Reactive oxidative metabolites are associated with atrial conduction disturbance in patients with atrial fibrillation</title><title>Heart rhythm</title><addtitle>Heart Rhythm</addtitle><description>Background Oxidative stress is associated with atrial fibrillation (AF). However, little is known about the relationship between serum markers of oxidation and electrical activity in patients with AF. Objective The purpose of this study was to investigate the possible association between serum markers of reactive oxidative metabolism and atrial remodeling in paroxysmal and persistent AF. Methods Derivatives of reactive oxidative metabolites (DROM), an index of oxidative stress, were measured in 306 consecutive patients with AF (225 paroxysmal, 81 persistent) undergoing radiofrequency (RF) catheter ablation. Filtered P-wave duration by P-wave signal-averaged ECG and levels of high-sensitivity C-reactive protein (CRP) as an inflammatory marker also were measured. Results Patients were followed up for 1.2 ± 0.8 years. DROM levels in patients with persistent AF were significantly higher than in patients with paroxysmal AF (341.6 ± 85.5 Carratelli [Carr] units vs 305.0 ± 77.7 Carr units, P <.001). DROM levels showed a tighter, positive correlation with filtered P-wave duration in persistent AF patients (r = 0.56, P <.001) than in all AF patients (r = 0.13, P <.05). DROM levels also showed a weaker but significant correlation with high-sensitivity CRP in patients with AF. Kaplan-Meier analysis revealed that the highest quartile of basal DROM levels exhibited a significantly higher AF recurrence rate after RF catheter ablation in patients with paroxysmal AF ( P <.01). Conclusion Serum markers of oxidative stress reflect atrial conduction disturbance and predict AF recurrence after RF catheter ablation in paroxysmal AF patients. DROM could serve as a biomarker for predicting risk of AF recurrence after RF catheter ablation.</description><subject>Ablation</subject><subject>Aged</subject><subject>Atrial fibrillation</subject><subject>Atrial Fibrillation - metabolism</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Biomarkers</subject><subject>Cardiovascular</subject><subject>Female</subject><subject>Heart Atria - metabolism</subject><subject>Heart Atria - physiopathology</subject><subject>Heart Conduction System - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxidative Stress</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Remodeling</subject><subject>Signal-averaged P wave</subject><issn>1547-5271</issn><issn>1556-3871</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2L1TAUhosozjj6CwTJyl3rSdI2zUJBBnUGBgQ_1iFNTri5ts01SceZf28694LoxlXO4nnfJM-pqpcUGgq0f7NvdjHv5oYByAZ4A5Q9qs5p1_U1HwR9vM2tqDsm6Fn1LKU9AJM98KfVGZVdDzDQ82r9gtpkf4sk3HmrH6YZsx7D5DMmoiMSnVIwXme05JfPO6Jz9HoiJix2LdmwEOtTXuOoF4PEL-RQenDJ6S_c-TH6adJb4Hn1xOkp4YvTeVF9__jh2-VVffP50_Xl-5vatJTlmrVd6-Q4ckDqgEvacRysNU6ia4VgdLBUcpBuHKmwwmJLpZb9KFghjHP8onp97D3E8HPFlNXsk8HyigXDmlQvWtb2MBSQH0ETQ0oRnTpEP-t4ryiozbbaqwfbarOtgKtiu6RenerXcUb7J3PSW4C3RwDLJ289RpVMMWPQ-ogmKxv8fy5490_eTH7xRk8_8B7TPqxxKf4UVYkpUF-3hW_7Bll2PQjGfwMjraoI</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Shimano, Masayuki, MD, PhD</creator><creator>Shibata, Rei, MD, PhD</creator><creator>Inden, Yasuya, MD, PhD</creator><creator>Yoshida, Naoki, MD</creator><creator>Uchikawa, Tomohiro, MD</creator><creator>Tsuji, Yukiomi, MD, PhD</creator><creator>Murohara, Toyoaki, MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Reactive oxidative metabolites are associated with atrial conduction disturbance in patients with atrial fibrillation</title><author>Shimano, Masayuki, MD, PhD ; Shibata, Rei, MD, PhD ; Inden, Yasuya, MD, PhD ; Yoshida, Naoki, MD ; Uchikawa, Tomohiro, MD ; Tsuji, Yukiomi, MD, PhD ; Murohara, Toyoaki, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-2454f9bb30e1f039153e8ddcf9ef477218d19309fbb17d7de419a96b72f9ecff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Ablation</topic><topic>Aged</topic><topic>Atrial fibrillation</topic><topic>Atrial Fibrillation - metabolism</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Biomarkers</topic><topic>Cardiovascular</topic><topic>Female</topic><topic>Heart Atria - metabolism</topic><topic>Heart Atria - physiopathology</topic><topic>Heart Conduction System - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxidative Stress</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Remodeling</topic><topic>Signal-averaged P wave</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimano, Masayuki, MD, PhD</creatorcontrib><creatorcontrib>Shibata, Rei, MD, PhD</creatorcontrib><creatorcontrib>Inden, Yasuya, MD, PhD</creatorcontrib><creatorcontrib>Yoshida, Naoki, MD</creatorcontrib><creatorcontrib>Uchikawa, Tomohiro, MD</creatorcontrib><creatorcontrib>Tsuji, Yukiomi, MD, PhD</creatorcontrib><creatorcontrib>Murohara, Toyoaki, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Heart rhythm</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimano, Masayuki, MD, PhD</au><au>Shibata, Rei, MD, PhD</au><au>Inden, Yasuya, MD, PhD</au><au>Yoshida, Naoki, MD</au><au>Uchikawa, Tomohiro, MD</au><au>Tsuji, Yukiomi, MD, PhD</au><au>Murohara, Toyoaki, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reactive oxidative metabolites are associated with atrial conduction disturbance in patients with atrial fibrillation</atitle><jtitle>Heart rhythm</jtitle><addtitle>Heart Rhythm</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>6</volume><issue>7</issue><spage>935</spage><epage>940</epage><pages>935-940</pages><issn>1547-5271</issn><eissn>1556-3871</eissn><abstract>Background Oxidative stress is associated with atrial fibrillation (AF). However, little is known about the relationship between serum markers of oxidation and electrical activity in patients with AF. Objective The purpose of this study was to investigate the possible association between serum markers of reactive oxidative metabolism and atrial remodeling in paroxysmal and persistent AF. Methods Derivatives of reactive oxidative metabolites (DROM), an index of oxidative stress, were measured in 306 consecutive patients with AF (225 paroxysmal, 81 persistent) undergoing radiofrequency (RF) catheter ablation. Filtered P-wave duration by P-wave signal-averaged ECG and levels of high-sensitivity C-reactive protein (CRP) as an inflammatory marker also were measured. Results Patients were followed up for 1.2 ± 0.8 years. DROM levels in patients with persistent AF were significantly higher than in patients with paroxysmal AF (341.6 ± 85.5 Carratelli [Carr] units vs 305.0 ± 77.7 Carr units, P <.001). DROM levels showed a tighter, positive correlation with filtered P-wave duration in persistent AF patients (r = 0.56, P <.001) than in all AF patients (r = 0.13, P <.05). DROM levels also showed a weaker but significant correlation with high-sensitivity CRP in patients with AF. Kaplan-Meier analysis revealed that the highest quartile of basal DROM levels exhibited a significantly higher AF recurrence rate after RF catheter ablation in patients with paroxysmal AF ( P <.01). Conclusion Serum markers of oxidative stress reflect atrial conduction disturbance and predict AF recurrence after RF catheter ablation in paroxysmal AF patients. DROM could serve as a biomarker for predicting risk of AF recurrence after RF catheter ablation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19560081</pmid><doi>10.1016/j.hrthm.2009.03.012</doi><tpages>6</tpages></addata></record> |
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| subjects | Ablation Aged Atrial fibrillation Atrial Fibrillation - metabolism Atrial Fibrillation - physiopathology Biomarkers Cardiovascular Female Heart Atria - metabolism Heart Atria - physiopathology Heart Conduction System - metabolism Humans Male Middle Aged Oxidative Stress Reactive Oxygen Species - metabolism Remodeling Signal-averaged P wave |
| title | Reactive oxidative metabolites are associated with atrial conduction disturbance in patients with atrial fibrillation |
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