Low expression of Wnt-5a gene is associated with high-risk neuroblastoma

Disseminated forms of neuroblastoma (NB), a tumor derived from neuroectodermal tissue, pose a major therapeutic challenge for pediatric oncology. By performing a comparative cDNA array analysis of metastatic neuroblasts versus primary xenograft from the human IGR-N-91 NB model, we were able to ident...

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Veröffentlicht in:	Oncogene 2005-02, Vol.24 (7), p.1277-1283
Hauptverfasser:	Blanc, Etienne, Roux, Gwenaëlle Le, Bénard, Jean, Raguénez, Gilda
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biological and medical sciences Bone marrow Cell Biology Cell differentiation Cell Differentiation - physiology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes DNA microarrays Down-Regulation - drug effects Down-Regulation - genetics Embryos Fundamental and applied biological sciences. Psychology Gene expression Gene Expression - drug effects Gene Expression Regulation, Neoplastic Human Genetics Humans Internal Medicine Isoenzymes - analysis Isoenzymes - genetics Medical sciences Medicine Medicine & Public Health Metastases Metastasis Molecular and cellular biology MYCN gene N-Myc Proto-Oncogene Protein Neoplasm Invasiveness Neural crest Neural Crest - drug effects Neural Crest - physiology Neurites - physiology Neuroblastoma Neuroblastoma - genetics Neuroblastoma - immunology Neuroblasts Neurology Neurons - cytology Neurons - immunology Neurons - physiology Nuclear Proteins - analysis Nuclear Proteins - genetics Oligonucleotide Array Sequence Analysis Oncogene Proteins - analysis Oncogene Proteins - genetics Oncology Pediatrics Prognosis Protein kinase C Protein Kinase C - analysis Protein Kinase C - genetics Protein Kinase C-theta Proto-Oncogene Proteins - analysis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Retinoic acid RNA, Messenger - analysis RNA, Messenger - metabolism short-report Signal transduction Tretinoin - pharmacology Tumors Tumors of the nervous system. Phacomatoses Up-Regulation - genetics Wnt protein Wnt Proteins Wnt-5a Protein Xenografts
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