The subcellular distribution of MnSOD alters during sodium selenite-induced apoptosis

It was reported that high doses of sodium selenite can induce apoptosis of cancer cells, but the molecular mechanisms are poorly understood. Manganese superoxide dismutase (MnSOD) converts superoxide radical to hydrogen peroxide within the mitochondrial matrix and is one of the most important antiox...

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Veröffentlicht in:	BMB reports 2009-06, Vol.42 (6), p.361-366
Hauptverfasser:	Guan, Liying (Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China), Jiang, Qian (Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China), Li, Zhushi (Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China), Huang, Fang (Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China), Ren, Yun (Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China), Yang, Yang (Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China), Xu, Caimin (Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China), E-mail: caiminxu@yahoo.com.cn
Format:	Artikel
Sprache:	eng
Schlagworte:	APOPTOSE APOPTOSIS Apoptosis - drug effects Apoptosis - physiology HL-60 Cells Humans Jurkat Cells MITOCHONDRIA Mitochondria - drug effects Mitochondria - metabolism MITOCHONDRIE MITOCONDRIA MnSOD Sodium selenite Sodium Selenite - pharmacology Superoxide Superoxide Dismutase - metabolism Superoxides - metabolism Superoxides - pharmacology Tissue Distribution - drug effects Tumor Cells, Cultured
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