Cyclic Nucleotide Signaling Mediates an Odorant-suppressible Chloride Conductance in Lobster Olfactory Receptor Neurons
We have previously shown that lobster olfactory receptor neurons (ORNs) express an odorant-suppressible Cl− conductance that modulates the output of the cells. Here, we develop a more complete pharmacological profile of this conductance, showing it is blockable by the Cl− channel blockers DIDS, 9-AC...
Gespeichert in:
| Veröffentlicht in: | Chemical senses 2005-02, Vol.30 (2), p.127-135 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 135 |
|---|---|
| container_issue | 2 |
| container_start_page | 127 |
| container_title | Chemical senses |
| container_volume | 30 |
| creator | Doolin, Richard E. Ache, Barry W. |
| description | We have previously shown that lobster olfactory receptor neurons (ORNs) express an odorant-suppressible Cl− conductance that modulates the output of the cells. Here, we develop a more complete pharmacological profile of this conductance, showing it is blockable by the Cl− channel blockers DIDS, 9-AC and flufenamic acid, but not by niflumic acid. We then show that a conductance with this pharmacological profile is mediated by cyclic nucleotide signaling. These findings further our understanding of the cellular mechanisms through which odorants can modulate the output of lobster ORNs. |
| doi_str_mv | 10.1093/chemse/bji008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67421090</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>800021021</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456t-bb03e6985f2abab315dfb39b1f44e74ac1e4813619beb3b7f7f85b3bb28a362c3</originalsourceid><addsrcrecordid>eNqFkd9rFDEQgIMo9qw--ipB0Le1-b2bR13UCucdtgqlLyHJzrY59zZnsovef2_KHS344tMMzDczzHwIvaTkHSWan_lb2GY4c5tASPMILahQouJS8sdoQXitq0aJqxP0LOcNIVRw1jxFJ1TWhHPOFuh3u_dD8Hg1-wHiFDrAl-FmtEMYb_BX6IKdIGM74nUXkx2nKs-7XYKcgxsAt7dDTHc9bRy72U929IDDiJfR5QkSXg-99VNMe3wBHnYlwyuYUxzzc_Skt0OGF8d4in58-vi9Pa-W689f2vfLyguppso5wkHpRvbMOus4lV3vuHa0FwJqYT0F0VCuqHbguKv7um9kSRxrLFfM81P09jB3l-KvGfJktiF7GAY7QpyzUbVg5Y_kvyCta0WY0AV8_Q-4iXMqHyuM1kxxTlmBqgPkU8w5QW92KWxt2htKzJ03c_BmDt4K_-o4dHZb6B7oo6gCvDkCNns79MWFD_mBU5JqVvTeLw5FwJ_7uk0_y6m8lub86tpcXK60vP6gzDf-F4KXs4o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199263312</pqid></control><display><type>article</type><title>Cyclic Nucleotide Signaling Mediates an Odorant-suppressible Chloride Conductance in Lobster Olfactory Receptor Neurons</title><source>MEDLINE</source><source>Free Full-Text Journals in Chemistry</source><source>EZB Electronic Journals Library</source><source>Oxford Journals</source><creator>Doolin, Richard E. ; Ache, Barry W.</creator><creatorcontrib>Doolin, Richard E. ; Ache, Barry W.</creatorcontrib><description>We have previously shown that lobster olfactory receptor neurons (ORNs) express an odorant-suppressible Cl− conductance that modulates the output of the cells. Here, we develop a more complete pharmacological profile of this conductance, showing it is blockable by the Cl− channel blockers DIDS, 9-AC and flufenamic acid, but not by niflumic acid. We then show that a conductance with this pharmacological profile is mediated by cyclic nucleotide signaling. These findings further our understanding of the cellular mechanisms through which odorants can modulate the output of lobster ORNs.</description><identifier>ISSN: 0379-864X</identifier><identifier>ISSN: 1464-3553</identifier><identifier>EISSN: 1464-3553</identifier><identifier>DOI: 10.1093/chemse/bji008</identifier><identifier>PMID: 15703332</identifier><identifier>CODEN: CHSED8</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>1-Methyl-3-isobutylxanthine - pharmacology ; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology ; Adenine - analogs & derivatives ; Adenine - pharmacology ; Adenylyl Cyclase Inhibitors ; Adenylyl Cyclases - physiology ; Animals ; Anthracenes - pharmacology ; Biochemistry. Physiology. Immunology ; Biological and medical sciences ; Chloride Channels - antagonists & inhibitors ; Chloride Channels - physiology ; Cl− conductance ; Colforsin - pharmacology ; Crustacea ; Cyclic AMP - pharmacology ; cyclic nucleotide signalling ; Electric Stimulation - methods ; Flufenamic Acid - pharmacology ; Fundamental and applied biological sciences. Psychology ; Homarus americanus ; Imines - pharmacology ; Invertebrates ; lobster ; Marine ; Nucleotides, Cyclic - antagonists & inhibitors ; Nucleotides, Cyclic - physiology ; olfaction ; Olfactory Receptor Neurons - drug effects ; Olfactory Receptor Neurons - physiology ; Palinuridae - drug effects ; Palinuridae - physiology ; Physiology. Development ; Signal Transduction - drug effects ; Signal Transduction - physiology</subject><ispartof>Chemical senses, 2005-02, Vol.30 (2), p.127-135</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Feb 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-bb03e6985f2abab315dfb39b1f44e74ac1e4813619beb3b7f7f85b3bb28a362c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16519214$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15703332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doolin, Richard E.</creatorcontrib><creatorcontrib>Ache, Barry W.</creatorcontrib><title>Cyclic Nucleotide Signaling Mediates an Odorant-suppressible Chloride Conductance in Lobster Olfactory Receptor Neurons</title><title>Chemical senses</title><addtitle>Chem. Senses</addtitle><description>We have previously shown that lobster olfactory receptor neurons (ORNs) express an odorant-suppressible Cl− conductance that modulates the output of the cells. Here, we develop a more complete pharmacological profile of this conductance, showing it is blockable by the Cl− channel blockers DIDS, 9-AC and flufenamic acid, but not by niflumic acid. We then show that a conductance with this pharmacological profile is mediated by cyclic nucleotide signaling. These findings further our understanding of the cellular mechanisms through which odorants can modulate the output of lobster ORNs.</description><subject>1-Methyl-3-isobutylxanthine - pharmacology</subject><subject>4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology</subject><subject>Adenine - analogs & derivatives</subject><subject>Adenine - pharmacology</subject><subject>Adenylyl Cyclase Inhibitors</subject><subject>Adenylyl Cyclases - physiology</subject><subject>Animals</subject><subject>Anthracenes - pharmacology</subject><subject>Biochemistry. Physiology. Immunology</subject><subject>Biological and medical sciences</subject><subject>Chloride Channels - antagonists & inhibitors</subject><subject>Chloride Channels - physiology</subject><subject>Cl− conductance</subject><subject>Colforsin - pharmacology</subject><subject>Crustacea</subject><subject>Cyclic AMP - pharmacology</subject><subject>cyclic nucleotide signalling</subject><subject>Electric Stimulation - methods</subject><subject>Flufenamic Acid - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Homarus americanus</subject><subject>Imines - pharmacology</subject><subject>Invertebrates</subject><subject>lobster</subject><subject>Marine</subject><subject>Nucleotides, Cyclic - antagonists & inhibitors</subject><subject>Nucleotides, Cyclic - physiology</subject><subject>olfaction</subject><subject>Olfactory Receptor Neurons - drug effects</subject><subject>Olfactory Receptor Neurons - physiology</subject><subject>Palinuridae - drug effects</subject><subject>Palinuridae - physiology</subject><subject>Physiology. Development</subject><subject>Signal Transduction - drug effects</subject><subject>Signal Transduction - physiology</subject><issn>0379-864X</issn><issn>1464-3553</issn><issn>1464-3553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9rFDEQgIMo9qw--ipB0Le1-b2bR13UCucdtgqlLyHJzrY59zZnsovef2_KHS344tMMzDczzHwIvaTkHSWan_lb2GY4c5tASPMILahQouJS8sdoQXitq0aJqxP0LOcNIVRw1jxFJ1TWhHPOFuh3u_dD8Hg1-wHiFDrAl-FmtEMYb_BX6IKdIGM74nUXkx2nKs-7XYKcgxsAt7dDTHc9bRy72U929IDDiJfR5QkSXg-99VNMe3wBHnYlwyuYUxzzc_Skt0OGF8d4in58-vi9Pa-W689f2vfLyguppso5wkHpRvbMOus4lV3vuHa0FwJqYT0F0VCuqHbguKv7um9kSRxrLFfM81P09jB3l-KvGfJktiF7GAY7QpyzUbVg5Y_kvyCta0WY0AV8_Q-4iXMqHyuM1kxxTlmBqgPkU8w5QW92KWxt2htKzJ03c_BmDt4K_-o4dHZb6B7oo6gCvDkCNns79MWFD_mBU5JqVvTeLw5FwJ_7uk0_y6m8lub86tpcXK60vP6gzDf-F4KXs4o</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Doolin, Richard E.</creator><creator>Ache, Barry W.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>20050201</creationdate><title>Cyclic Nucleotide Signaling Mediates an Odorant-suppressible Chloride Conductance in Lobster Olfactory Receptor Neurons</title><author>Doolin, Richard E. ; Ache, Barry W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-bb03e6985f2abab315dfb39b1f44e74ac1e4813619beb3b7f7f85b3bb28a362c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>1-Methyl-3-isobutylxanthine - pharmacology</topic><topic>4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology</topic><topic>Adenine - analogs & derivatives</topic><topic>Adenine - pharmacology</topic><topic>Adenylyl Cyclase Inhibitors</topic><topic>Adenylyl Cyclases - physiology</topic><topic>Animals</topic><topic>Anthracenes - pharmacology</topic><topic>Biochemistry. Physiology. Immunology</topic><topic>Biological and medical sciences</topic><topic>Chloride Channels - antagonists & inhibitors</topic><topic>Chloride Channels - physiology</topic><topic>Cl− conductance</topic><topic>Colforsin - pharmacology</topic><topic>Crustacea</topic><topic>Cyclic AMP - pharmacology</topic><topic>cyclic nucleotide signalling</topic><topic>Electric Stimulation - methods</topic><topic>Flufenamic Acid - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Homarus americanus</topic><topic>Imines - pharmacology</topic><topic>Invertebrates</topic><topic>lobster</topic><topic>Marine</topic><topic>Nucleotides, Cyclic - antagonists & inhibitors</topic><topic>Nucleotides, Cyclic - physiology</topic><topic>olfaction</topic><topic>Olfactory Receptor Neurons - drug effects</topic><topic>Olfactory Receptor Neurons - physiology</topic><topic>Palinuridae - drug effects</topic><topic>Palinuridae - physiology</topic><topic>Physiology. Development</topic><topic>Signal Transduction - drug effects</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doolin, Richard E.</creatorcontrib><creatorcontrib>Ache, Barry W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical senses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doolin, Richard E.</au><au>Ache, Barry W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclic Nucleotide Signaling Mediates an Odorant-suppressible Chloride Conductance in Lobster Olfactory Receptor Neurons</atitle><jtitle>Chemical senses</jtitle><addtitle>Chem. Senses</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>30</volume><issue>2</issue><spage>127</spage><epage>135</epage><pages>127-135</pages><issn>0379-864X</issn><issn>1464-3553</issn><eissn>1464-3553</eissn><coden>CHSED8</coden><abstract>We have previously shown that lobster olfactory receptor neurons (ORNs) express an odorant-suppressible Cl− conductance that modulates the output of the cells. Here, we develop a more complete pharmacological profile of this conductance, showing it is blockable by the Cl− channel blockers DIDS, 9-AC and flufenamic acid, but not by niflumic acid. We then show that a conductance with this pharmacological profile is mediated by cyclic nucleotide signaling. These findings further our understanding of the cellular mechanisms through which odorants can modulate the output of lobster ORNs.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15703332</pmid><doi>10.1093/chemse/bji008</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0379-864X |
| ispartof | Chemical senses, 2005-02, Vol.30 (2), p.127-135 |
| issn | 0379-864X 1464-3553 1464-3553 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67421090 |
| source | MEDLINE; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library; Oxford Journals |
| subjects | 1-Methyl-3-isobutylxanthine - pharmacology 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology Adenine - analogs & derivatives Adenine - pharmacology Adenylyl Cyclase Inhibitors Adenylyl Cyclases - physiology Animals Anthracenes - pharmacology Biochemistry. Physiology. Immunology Biological and medical sciences Chloride Channels - antagonists & inhibitors Chloride Channels - physiology Cl− conductance Colforsin - pharmacology Crustacea Cyclic AMP - pharmacology cyclic nucleotide signalling Electric Stimulation - methods Flufenamic Acid - pharmacology Fundamental and applied biological sciences. Psychology Homarus americanus Imines - pharmacology Invertebrates lobster Marine Nucleotides, Cyclic - antagonists & inhibitors Nucleotides, Cyclic - physiology olfaction Olfactory Receptor Neurons - drug effects Olfactory Receptor Neurons - physiology Palinuridae - drug effects Palinuridae - physiology Physiology. Development Signal Transduction - drug effects Signal Transduction - physiology |
| title | Cyclic Nucleotide Signaling Mediates an Odorant-suppressible Chloride Conductance in Lobster Olfactory Receptor Neurons |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T17%3A18%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cyclic%20Nucleotide%20Signaling%20Mediates%20an%20Odorant-suppressible%20Chloride%20Conductance%20in%20Lobster%20Olfactory%20Receptor%20Neurons&rft.jtitle=Chemical%20senses&rft.au=Doolin,%20Richard%20E.&rft.date=2005-02-01&rft.volume=30&rft.issue=2&rft.spage=127&rft.epage=135&rft.pages=127-135&rft.issn=0379-864X&rft.eissn=1464-3553&rft.coden=CHSED8&rft_id=info:doi/10.1093/chemse/bji008&rft_dat=%3Cproquest_cross%3E800021021%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=199263312&rft_id=info:pmid/15703332&rfr_iscdi=true |