The first total synthesis of kwakhurin, a characteristic component of a rejuvenating plant, "kwao keur": toward an efficient synthetic route to phytoestrogenic isoflavones

A convergent synthesis of kwakhurin (5), a characteristic estrogen-like isoflavone of Pueraria mirifica(Leguminosae), is described. Isoflavone skeleton 31 was constructed by Suzuki-Miyaura coupling of 3-bromochromone 26 (AC-ring) and arylboronic acid 30 (B-ring) in the presence of TBAB as an additiv...

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Veröffentlicht in:	Organic & biomolecular chemistry 2005-02, Vol.3 (4), p.674-681
Hauptverfasser:	Ito, Fumihiro, Iwasaki, Misako, Watanabe, Toshiko, Ishikawa, Tsutomu, Higuchi, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Boronic Acids - chemistry Chromones - chemistry Heterocyclic Compounds, 3-Ring - chemical synthesis Heterocyclic Compounds, 3-Ring - chemistry Isoflavones - chemical synthesis Isoflavones - chemistry Methylation Molecular Structure Oxidation-Reduction Phytoestrogens - chemical synthesis Phytoestrogens - chemistry Pueraria - chemistry
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