In vitro activity of amphotericin B, itraconazole and voriconazole against 20 species of Aspergillus using the Sensititre microdilution method
The in vitro activity of antifungal agents against Aspergillus has been recently investigated. We studied the susceptibility to amphotericin B, itraconazole and voriconazole of 68 strains belonging to 20 different Aspergillus species. The minimum inhibitory concentrations (MICs) for 10 strains of A....
Gespeichert in:
| Veröffentlicht in: | Enfermedades infecciosas y microbiología clínica 2005-01, Vol.23 (1), p.15-18 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | spa |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 18 |
|---|---|
| container_issue | 1 |
| container_start_page | 15 |
| container_title | Enfermedades infecciosas y microbiología clínica |
| container_volume | 23 |
| creator | García-Martos, Pedro García-Agudo, Lidia Gutiérrez-Calzada, Jesús Ruiz-Aragón, Jesús Saldarreaga, Abel Marín, Pilar |
| description | The in vitro activity of antifungal agents against Aspergillus has been recently investigated. We studied the susceptibility to amphotericin B, itraconazole and voriconazole of 68 strains belonging to 20 different Aspergillus species.
The minimum inhibitory concentrations (MICs) for 10 strains of A. fumigatus, 9 A. flavus, 8 A. niger, 5 A. tamarii, 5 A. versicolor, 4 A. terreus, 3 A. glaucus, 3 A. ochraceus, 3 A. oryzae, 2 A. candidus, 2 A. chevalieri, 2 A. rubrobrunneus, 2 A. sclerotiorum, 2 A. sydowii, 2 A. unguis, 2 A. ustus, 1 A. clavatus, 1 A. nidulans, 1 A. pseudofischeri y 1 A. reptans, were determined using the Sensititre Yeast One microdilution method.
Voriconazole was more active in vitro than amphotericin B and itraconazole, with 95.6% (65/68) of strains exhibiting MICs of < or = 2 mg/l. A. flavus, A. versicolor, A. terreus, A. ochraceus, A. sclerotiorum, A. ustus and A. reptans species presented reduced susceptibility to amphotericin B (MIC > or = 2 mg/l); A. niger, A. versicolor, A. sclerotiorum and A. ustus showed in vitro resistance to itraconazole (MIC > or = 1 mg/l); and A. sclerotiorum and A. ustus displayed poor susceptibility to voriconazole (MIC > or = 2 mg/l).
The susceptibility of Aspergillus species to itraconazole and voriconazole was generally good; nevertheless, susceptibility to amphotericin B was low. These results suggest that Aspergillus susceptibility testing to this antifungal agent would be advisable to guide treatment. |
| doi_str_mv | 10.1157/13070403 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67419882</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67419882</sourcerecordid><originalsourceid>FETCH-LOGICAL-p139t-1983c77a90ce5ac08794c4866c60c93545c8fb307eacd9ae583dc0ed1162cda63</originalsourceid><addsrcrecordid>eNo9kE1LAzEQhnNQbP0Af4Hk5MnVyWY_j7X4USh4UMFbSSfTNrKbrJtsof4If7MRq6d5mXl4Bl7GzgVcC5GXN0JCCRnIAzaGVMgEIH8bsWPv3wHSXEp5xEaRAyHTcsy-ZpZvTegdVxhMTDvuVly13cYF6g0ay2-veAQUOqs-XUNcWc23Lt7-F2tlrA88Be47QkP-xzGJuV-bphk8H7yxax42xJ_JehOij3hrsHfaNEMwzvKWwsbpU3a4Uo2ns_08Ya_3dy_Tx2T-9DCbTuZJJ2QdElFXEstS1YCUK4SqrDPMqqLAArCWeZZjtVrGIkihrhXlldQIpIUoUtSqkCfs8tfb9e5jIB8WrfFITaMsucEvijKLP6o0ghd7cFi2pBddb1rV7xZ_DcpvuAhynw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67419882</pqid></control><display><type>article</type><title>In vitro activity of amphotericin B, itraconazole and voriconazole against 20 species of Aspergillus using the Sensititre microdilution method</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>García-Martos, Pedro ; García-Agudo, Lidia ; Gutiérrez-Calzada, Jesús ; Ruiz-Aragón, Jesús ; Saldarreaga, Abel ; Marín, Pilar</creator><creatorcontrib>García-Martos, Pedro ; García-Agudo, Lidia ; Gutiérrez-Calzada, Jesús ; Ruiz-Aragón, Jesús ; Saldarreaga, Abel ; Marín, Pilar</creatorcontrib><description>The in vitro activity of antifungal agents against Aspergillus has been recently investigated. We studied the susceptibility to amphotericin B, itraconazole and voriconazole of 68 strains belonging to 20 different Aspergillus species.
The minimum inhibitory concentrations (MICs) for 10 strains of A. fumigatus, 9 A. flavus, 8 A. niger, 5 A. tamarii, 5 A. versicolor, 4 A. terreus, 3 A. glaucus, 3 A. ochraceus, 3 A. oryzae, 2 A. candidus, 2 A. chevalieri, 2 A. rubrobrunneus, 2 A. sclerotiorum, 2 A. sydowii, 2 A. unguis, 2 A. ustus, 1 A. clavatus, 1 A. nidulans, 1 A. pseudofischeri y 1 A. reptans, were determined using the Sensititre Yeast One microdilution method.
Voriconazole was more active in vitro than amphotericin B and itraconazole, with 95.6% (65/68) of strains exhibiting MICs of < or = 2 mg/l. A. flavus, A. versicolor, A. terreus, A. ochraceus, A. sclerotiorum, A. ustus and A. reptans species presented reduced susceptibility to amphotericin B (MIC > or = 2 mg/l); A. niger, A. versicolor, A. sclerotiorum and A. ustus showed in vitro resistance to itraconazole (MIC > or = 1 mg/l); and A. sclerotiorum and A. ustus displayed poor susceptibility to voriconazole (MIC > or = 2 mg/l).
The susceptibility of Aspergillus species to itraconazole and voriconazole was generally good; nevertheless, susceptibility to amphotericin B was low. These results suggest that Aspergillus susceptibility testing to this antifungal agent would be advisable to guide treatment.</description><identifier>ISSN: 0213-005X</identifier><identifier>DOI: 10.1157/13070403</identifier><identifier>PMID: 15701327</identifier><language>spa</language><publisher>Spain</publisher><subject>Amphotericin B - pharmacology ; Antifungal Agents - pharmacology ; Aspergillus - classification ; Aspergillus - drug effects ; Drug Resistance, Fungal ; Itraconazole - pharmacology ; Microbial Sensitivity Tests - methods ; Pyrimidines - pharmacology ; Species Specificity ; Triazoles - pharmacology ; Voriconazole</subject><ispartof>Enfermedades infecciosas y microbiología clínica, 2005-01, Vol.23 (1), p.15-18</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15701327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García-Martos, Pedro</creatorcontrib><creatorcontrib>García-Agudo, Lidia</creatorcontrib><creatorcontrib>Gutiérrez-Calzada, Jesús</creatorcontrib><creatorcontrib>Ruiz-Aragón, Jesús</creatorcontrib><creatorcontrib>Saldarreaga, Abel</creatorcontrib><creatorcontrib>Marín, Pilar</creatorcontrib><title>In vitro activity of amphotericin B, itraconazole and voriconazole against 20 species of Aspergillus using the Sensititre microdilution method</title><title>Enfermedades infecciosas y microbiología clínica</title><addtitle>Enferm Infecc Microbiol Clin</addtitle><description>The in vitro activity of antifungal agents against Aspergillus has been recently investigated. We studied the susceptibility to amphotericin B, itraconazole and voriconazole of 68 strains belonging to 20 different Aspergillus species.
The minimum inhibitory concentrations (MICs) for 10 strains of A. fumigatus, 9 A. flavus, 8 A. niger, 5 A. tamarii, 5 A. versicolor, 4 A. terreus, 3 A. glaucus, 3 A. ochraceus, 3 A. oryzae, 2 A. candidus, 2 A. chevalieri, 2 A. rubrobrunneus, 2 A. sclerotiorum, 2 A. sydowii, 2 A. unguis, 2 A. ustus, 1 A. clavatus, 1 A. nidulans, 1 A. pseudofischeri y 1 A. reptans, were determined using the Sensititre Yeast One microdilution method.
Voriconazole was more active in vitro than amphotericin B and itraconazole, with 95.6% (65/68) of strains exhibiting MICs of < or = 2 mg/l. A. flavus, A. versicolor, A. terreus, A. ochraceus, A. sclerotiorum, A. ustus and A. reptans species presented reduced susceptibility to amphotericin B (MIC > or = 2 mg/l); A. niger, A. versicolor, A. sclerotiorum and A. ustus showed in vitro resistance to itraconazole (MIC > or = 1 mg/l); and A. sclerotiorum and A. ustus displayed poor susceptibility to voriconazole (MIC > or = 2 mg/l).
The susceptibility of Aspergillus species to itraconazole and voriconazole was generally good; nevertheless, susceptibility to amphotericin B was low. These results suggest that Aspergillus susceptibility testing to this antifungal agent would be advisable to guide treatment.</description><subject>Amphotericin B - pharmacology</subject><subject>Antifungal Agents - pharmacology</subject><subject>Aspergillus - classification</subject><subject>Aspergillus - drug effects</subject><subject>Drug Resistance, Fungal</subject><subject>Itraconazole - pharmacology</subject><subject>Microbial Sensitivity Tests - methods</subject><subject>Pyrimidines - pharmacology</subject><subject>Species Specificity</subject><subject>Triazoles - pharmacology</subject><subject>Voriconazole</subject><issn>0213-005X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LAzEQhnNQbP0Af4Hk5MnVyWY_j7X4USh4UMFbSSfTNrKbrJtsof4If7MRq6d5mXl4Bl7GzgVcC5GXN0JCCRnIAzaGVMgEIH8bsWPv3wHSXEp5xEaRAyHTcsy-ZpZvTegdVxhMTDvuVly13cYF6g0ay2-veAQUOqs-XUNcWc23Lt7-F2tlrA88Be47QkP-xzGJuV-bphk8H7yxax42xJ_JehOij3hrsHfaNEMwzvKWwsbpU3a4Uo2ns_08Ya_3dy_Tx2T-9DCbTuZJJ2QdElFXEstS1YCUK4SqrDPMqqLAArCWeZZjtVrGIkihrhXlldQIpIUoUtSqkCfs8tfb9e5jIB8WrfFITaMsucEvijKLP6o0ghd7cFi2pBddb1rV7xZ_DcpvuAhynw</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>García-Martos, Pedro</creator><creator>García-Agudo, Lidia</creator><creator>Gutiérrez-Calzada, Jesús</creator><creator>Ruiz-Aragón, Jesús</creator><creator>Saldarreaga, Abel</creator><creator>Marín, Pilar</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200501</creationdate><title>In vitro activity of amphotericin B, itraconazole and voriconazole against 20 species of Aspergillus using the Sensititre microdilution method</title><author>García-Martos, Pedro ; García-Agudo, Lidia ; Gutiérrez-Calzada, Jesús ; Ruiz-Aragón, Jesús ; Saldarreaga, Abel ; Marín, Pilar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p139t-1983c77a90ce5ac08794c4866c60c93545c8fb307eacd9ae583dc0ed1162cda63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2005</creationdate><topic>Amphotericin B - pharmacology</topic><topic>Antifungal Agents - pharmacology</topic><topic>Aspergillus - classification</topic><topic>Aspergillus - drug effects</topic><topic>Drug Resistance, Fungal</topic><topic>Itraconazole - pharmacology</topic><topic>Microbial Sensitivity Tests - methods</topic><topic>Pyrimidines - pharmacology</topic><topic>Species Specificity</topic><topic>Triazoles - pharmacology</topic><topic>Voriconazole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García-Martos, Pedro</creatorcontrib><creatorcontrib>García-Agudo, Lidia</creatorcontrib><creatorcontrib>Gutiérrez-Calzada, Jesús</creatorcontrib><creatorcontrib>Ruiz-Aragón, Jesús</creatorcontrib><creatorcontrib>Saldarreaga, Abel</creatorcontrib><creatorcontrib>Marín, Pilar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Enfermedades infecciosas y microbiología clínica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García-Martos, Pedro</au><au>García-Agudo, Lidia</au><au>Gutiérrez-Calzada, Jesús</au><au>Ruiz-Aragón, Jesús</au><au>Saldarreaga, Abel</au><au>Marín, Pilar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro activity of amphotericin B, itraconazole and voriconazole against 20 species of Aspergillus using the Sensititre microdilution method</atitle><jtitle>Enfermedades infecciosas y microbiología clínica</jtitle><addtitle>Enferm Infecc Microbiol Clin</addtitle><date>2005-01</date><risdate>2005</risdate><volume>23</volume><issue>1</issue><spage>15</spage><epage>18</epage><pages>15-18</pages><issn>0213-005X</issn><abstract>The in vitro activity of antifungal agents against Aspergillus has been recently investigated. We studied the susceptibility to amphotericin B, itraconazole and voriconazole of 68 strains belonging to 20 different Aspergillus species.
The minimum inhibitory concentrations (MICs) for 10 strains of A. fumigatus, 9 A. flavus, 8 A. niger, 5 A. tamarii, 5 A. versicolor, 4 A. terreus, 3 A. glaucus, 3 A. ochraceus, 3 A. oryzae, 2 A. candidus, 2 A. chevalieri, 2 A. rubrobrunneus, 2 A. sclerotiorum, 2 A. sydowii, 2 A. unguis, 2 A. ustus, 1 A. clavatus, 1 A. nidulans, 1 A. pseudofischeri y 1 A. reptans, were determined using the Sensititre Yeast One microdilution method.
Voriconazole was more active in vitro than amphotericin B and itraconazole, with 95.6% (65/68) of strains exhibiting MICs of < or = 2 mg/l. A. flavus, A. versicolor, A. terreus, A. ochraceus, A. sclerotiorum, A. ustus and A. reptans species presented reduced susceptibility to amphotericin B (MIC > or = 2 mg/l); A. niger, A. versicolor, A. sclerotiorum and A. ustus showed in vitro resistance to itraconazole (MIC > or = 1 mg/l); and A. sclerotiorum and A. ustus displayed poor susceptibility to voriconazole (MIC > or = 2 mg/l).
The susceptibility of Aspergillus species to itraconazole and voriconazole was generally good; nevertheless, susceptibility to amphotericin B was low. These results suggest that Aspergillus susceptibility testing to this antifungal agent would be advisable to guide treatment.</abstract><cop>Spain</cop><pmid>15701327</pmid><doi>10.1157/13070403</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0213-005X |
| ispartof | Enfermedades infecciosas y microbiología clínica, 2005-01, Vol.23 (1), p.15-18 |
| issn | 0213-005X |
| language | spa |
| recordid | cdi_proquest_miscellaneous_67419882 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Amphotericin B - pharmacology Antifungal Agents - pharmacology Aspergillus - classification Aspergillus - drug effects Drug Resistance, Fungal Itraconazole - pharmacology Microbial Sensitivity Tests - methods Pyrimidines - pharmacology Species Specificity Triazoles - pharmacology Voriconazole |
| title | In vitro activity of amphotericin B, itraconazole and voriconazole against 20 species of Aspergillus using the Sensititre microdilution method |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T22%3A15%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20vitro%20activity%20of%20amphotericin%20B,%20itraconazole%20and%20voriconazole%20against%2020%20species%20of%20Aspergillus%20using%20the%20Sensititre%20microdilution%20method&rft.jtitle=Enfermedades%20infecciosas%20y%20microbiolog%C3%ADa%20cl%C3%ADnica&rft.au=Garc%C3%ADa-Martos,%20Pedro&rft.date=2005-01&rft.volume=23&rft.issue=1&rft.spage=15&rft.epage=18&rft.pages=15-18&rft.issn=0213-005X&rft_id=info:doi/10.1157/13070403&rft_dat=%3Cproquest_pubme%3E67419882%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67419882&rft_id=info:pmid/15701327&rfr_iscdi=true |