Whole-grain rye and wheat alkylresorcinols are incorporated into human erythrocyte membranes
Alkylresorcinols (AR), a group of phenolic lipids, exist in the human diet in whole-grain rye and wheat. They are absorbed by humans and have been quantified in plasma. In this 2-week study we assessed AR incorporation into human erythrocyte membranes. Nine subjects attended the study; four avoided...
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| Veröffentlicht in: | British journal of nutrition 2005-01, Vol.93 (1), p.11-13 |
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| description | Alkylresorcinols (AR), a group of phenolic lipids, exist in the human diet in whole-grain rye and wheat. They are absorbed by humans and have been quantified in plasma. In this 2-week study we assessed AR incorporation into human erythrocyte membranes. Nine subjects attended the study; four avoided whole-grain products for 1 week and then included whole-grain rye and wheat bread in the diet for the second week, four included whole-grain rye and wheat products in the diet during the whole follow-up and one followed a gluten-free diet. Plasma and erythrocyte membrane AR were analysed after weeks 1 and 2. Erythrocyte membrane AR concentrations increased an average of 231 nmol/l of packed erythrocytes (P=0·036) after consumption of whole-grain rye and wheat products. Plasma AR levels increased an average of 175 nmol/l (P=0·058) When intake of whole-grain products was constant, erythrocyte membrane and plasma AR levels remained stable. Long-chain AR were incorporated into erythrocyte membranes in a higher proportion compared to shorter-chain AR. This preliminary study shows that AR are incorporated into human erythrocyte membranes in vivo. |
| doi_str_mv | 10.1079/BJN20041281 |
| format | Article |
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They are absorbed by humans and have been quantified in plasma. In this 2-week study we assessed AR incorporation into human erythrocyte membranes. Nine subjects attended the study; four avoided whole-grain products for 1 week and then included whole-grain rye and wheat bread in the diet for the second week, four included whole-grain rye and wheat products in the diet during the whole follow-up and one followed a gluten-free diet. Plasma and erythrocyte membrane AR were analysed after weeks 1 and 2. Erythrocyte membrane AR concentrations increased an average of 231 nmol/l of packed erythrocytes (P=0·036) after consumption of whole-grain rye and wheat products. Plasma AR levels increased an average of 175 nmol/l (P=0·058) When intake of whole-grain products was constant, erythrocyte membrane and plasma AR levels remained stable. Long-chain AR were incorporated into erythrocyte membranes in a higher proportion compared to shorter-chain AR. This preliminary study shows that AR are incorporated into human erythrocyte membranes in vivo.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN20041281</identifier><identifier>PMID: 15705219</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Alkylresorcinols ; Barley ; Biological and medical sciences ; Biomarkers ; Blood ; blood serum ; Bread ; Bread - analysis ; Diet ; Dietary Fiber - metabolism ; Erythrocyte Membrane - metabolism ; Erythrocyte membranes ; Erythrocytes ; Feeding. Feeding behavior ; food intake ; Fundamental and applied biological sciences. Psychology ; Gluten ; Grain ; Humans ; Lipids ; Membranes ; nutrient uptake ; Nutrition research ; Phenols ; Plasma ; Resorcinols - blood ; Resorcinols - pharmacokinetics ; reticulocytes ; rye ; Secale - metabolism ; Triticum - metabolism ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; volunteers ; Wheat ; Whole grain ; whole grain foods</subject><ispartof>British journal of nutrition, 2005-01, Vol.93 (1), p.11-13</ispartof><rights>Copyright © The Nutrition Society 2005</rights><rights>2005 INIST-CNRS</rights><rights>The Nutrition Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-4fde2e430ef5f33627ced7df50713cfb08f8132b89b9ccc37ceeda5803b776ee3</citedby><cites>FETCH-LOGICAL-c481t-4fde2e430ef5f33627ced7df50713cfb08f8132b89b9ccc37ceeda5803b776ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4014,27914,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16480054$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15705219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Linko, Anna-Maria</creatorcontrib><creatorcontrib>Adlercreutz, Herman</creatorcontrib><title>Whole-grain rye and wheat alkylresorcinols are incorporated into human erythrocyte membranes</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Alkylresorcinols (AR), a group of phenolic lipids, exist in the human diet in whole-grain rye and wheat. They are absorbed by humans and have been quantified in plasma. In this 2-week study we assessed AR incorporation into human erythrocyte membranes. Nine subjects attended the study; four avoided whole-grain products for 1 week and then included whole-grain rye and wheat bread in the diet for the second week, four included whole-grain rye and wheat products in the diet during the whole follow-up and one followed a gluten-free diet. Plasma and erythrocyte membrane AR were analysed after weeks 1 and 2. Erythrocyte membrane AR concentrations increased an average of 231 nmol/l of packed erythrocytes (P=0·036) after consumption of whole-grain rye and wheat products. Plasma AR levels increased an average of 175 nmol/l (P=0·058) When intake of whole-grain products was constant, erythrocyte membrane and plasma AR levels remained stable. Long-chain AR were incorporated into erythrocyte membranes in a higher proportion compared to shorter-chain AR. This preliminary study shows that AR are incorporated into human erythrocyte membranes in vivo.</description><subject>Alkylresorcinols</subject><subject>Barley</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>blood serum</subject><subject>Bread</subject><subject>Bread - analysis</subject><subject>Diet</subject><subject>Dietary Fiber - metabolism</subject><subject>Erythrocyte Membrane - metabolism</subject><subject>Erythrocyte membranes</subject><subject>Erythrocytes</subject><subject>Feeding. Feeding behavior</subject><subject>food intake</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gluten</subject><subject>Grain</subject><subject>Humans</subject><subject>Lipids</subject><subject>Membranes</subject><subject>nutrient uptake</subject><subject>Nutrition research</subject><subject>Phenols</subject><subject>Plasma</subject><subject>Resorcinols - blood</subject><subject>Resorcinols - pharmacokinetics</subject><subject>reticulocytes</subject><subject>rye</subject><subject>Secale - metabolism</subject><subject>Triticum - metabolism</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>volunteers</subject><subject>Wheat</subject><subject>Whole grain</subject><subject>whole grain foods</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkV2L1DAUhoMo7rh65b0WQW-kek7SNunlfuuyKOIueiGEND2Z6W7bjEmLzr83MoMj4lU4nIeX9zxh7CnCGwRZvz2-_MABCuQK77EFFrLMeVXx-2wBADJHLMoD9ijG2zQqhPohO8BSQsmxXrBvX1a-p3wZTDdmYUOZGdvsx4rMlJn-btMHij7YbvR9zEygrButD2sfzERtGiafrebBjBmFzbQK3m4mygYammBGio_ZA2f6SE927yG7OT-7PnmXX328eH9ydJXbQuGUF64lToUAcqUTouLSUitbV4JEYV0DyikUvFF1U1trRVpTa0oFopGyIhKH7NU2dx3895nipIcuWur7VMLPUVeywLrCOoEv_gFv_RzG1E1zFErwZC9Br7eQDT7GQE6vQzeYsNEI-rdx_ZfxRD_bRc7NQO2e3SlOwMsdYKI1vUtmbBf3XFUogLJIXL7lujjRzz97E-5SfyFLXV180pfn1_wY8as-TfzzLe-M12YZUubNZw4oAOo6SVT7RGvSh3Ttkvbn_u-UX220r54</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Linko, Anna-Maria</creator><creator>Adlercreutz, Herman</creator><general>Cambridge University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>200501</creationdate><title>Whole-grain rye and wheat alkylresorcinols are incorporated into human erythrocyte membranes</title><author>Linko, Anna-Maria ; Adlercreutz, Herman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-4fde2e430ef5f33627ced7df50713cfb08f8132b89b9ccc37ceeda5803b776ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Alkylresorcinols</topic><topic>Barley</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Blood</topic><topic>blood serum</topic><topic>Bread</topic><topic>Bread - analysis</topic><topic>Diet</topic><topic>Dietary Fiber - metabolism</topic><topic>Erythrocyte Membrane - metabolism</topic><topic>Erythrocyte membranes</topic><topic>Erythrocytes</topic><topic>Feeding. Feeding behavior</topic><topic>food intake</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gluten</topic><topic>Grain</topic><topic>Humans</topic><topic>Lipids</topic><topic>Membranes</topic><topic>nutrient uptake</topic><topic>Nutrition research</topic><topic>Phenols</topic><topic>Plasma</topic><topic>Resorcinols - blood</topic><topic>Resorcinols - pharmacokinetics</topic><topic>reticulocytes</topic><topic>rye</topic><topic>Secale - metabolism</topic><topic>Triticum - metabolism</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>volunteers</topic><topic>Wheat</topic><topic>Whole grain</topic><topic>whole grain foods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Linko, Anna-Maria</creatorcontrib><creatorcontrib>Adlercreutz, Herman</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Linko, Anna-Maria</au><au>Adlercreutz, Herman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole-grain rye and wheat alkylresorcinols are incorporated into human erythrocyte membranes</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2005-01</date><risdate>2005</risdate><volume>93</volume><issue>1</issue><spage>11</spage><epage>13</epage><pages>11-13</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Alkylresorcinols (AR), a group of phenolic lipids, exist in the human diet in whole-grain rye and wheat. They are absorbed by humans and have been quantified in plasma. In this 2-week study we assessed AR incorporation into human erythrocyte membranes. Nine subjects attended the study; four avoided whole-grain products for 1 week and then included whole-grain rye and wheat bread in the diet for the second week, four included whole-grain rye and wheat products in the diet during the whole follow-up and one followed a gluten-free diet. Plasma and erythrocyte membrane AR were analysed after weeks 1 and 2. Erythrocyte membrane AR concentrations increased an average of 231 nmol/l of packed erythrocytes (P=0·036) after consumption of whole-grain rye and wheat products. Plasma AR levels increased an average of 175 nmol/l (P=0·058) When intake of whole-grain products was constant, erythrocyte membrane and plasma AR levels remained stable. Long-chain AR were incorporated into erythrocyte membranes in a higher proportion compared to shorter-chain AR. This preliminary study shows that AR are incorporated into human erythrocyte membranes in vivo.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>15705219</pmid><doi>10.1079/BJN20041281</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alkylresorcinols Barley Biological and medical sciences Biomarkers Blood blood serum Bread Bread - analysis Diet Dietary Fiber - metabolism Erythrocyte Membrane - metabolism Erythrocyte membranes Erythrocytes Feeding. Feeding behavior food intake Fundamental and applied biological sciences. Psychology Gluten Grain Humans Lipids Membranes nutrient uptake Nutrition research Phenols Plasma Resorcinols - blood Resorcinols - pharmacokinetics reticulocytes rye Secale - metabolism Triticum - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems volunteers Wheat Whole grain whole grain foods |
| title | Whole-grain rye and wheat alkylresorcinols are incorporated into human erythrocyte membranes |
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