The Effect of Zinc Salts on Serum Bilirubin Levels in Hyperbilirubinemic Rats
ABSTRACT Objectives: Intestinal metabolism of bilirubin is implicated in the pathogenesis of neonatal jaundice and Crigler‐Najjar syndrome. In the present study the authors investigated the effect of oral administration of zinc salts on serum bilirubin levels in hyperbilirubinemic rats. Methods: Bil...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 2005-02, Vol.40 (2), p.135-140 |
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| creator | Vítek, Libor Muchová, Lucie Zelenka, Jaroslav Zadinová, Marie Malina, Jiří |
| description | ABSTRACT
Objectives:
Intestinal metabolism of bilirubin is implicated in the pathogenesis of neonatal jaundice and Crigler‐Najjar syndrome. In the present study the authors investigated the effect of oral administration of zinc salts on serum bilirubin levels in hyperbilirubinemic rats.
Methods:
Bilirubin‐binding activities of zinc sulfate and water‐insoluble zinc methacrylate were determined in vitro. Congenitally hyperbilirubinemic Gunn rats and artificially hyperbilirubinemic Wistar rats were used in in vivo studies. Animals were fed a normal diet for 1 week and then a treatment diet of either zinc sulfate or zinc methacrylate for additional 2 weeks. Serum and fecal bile pigments were determined at the end of each phase. Biliary bilirubin secretion rates were determined in hyperbilirubinemic Wistar rats fed zinc methacrylate.
Results:
Substantial bilirubin‐binding activities of zinc salts were demonstrated in in vitro experiments. Treatment with oral zinc salts significantly decreased serum bilirubin levels in Gunn rats (166 ± 53 versus 123 ± 38 and 206 ± 34 versus 131 ± 31 μmol/L, P < 0.05 for zinc methacrylate and zinc sulfate, respectively). A similar effect of zinc methacrylate was also observed in hyperbilirubinemic Wistar rats (102 ± 10 versus 14 ± 4 μmol/L, P < 0.0001). In accord, biliary bilirubin secretion decreased significantly in these animals (45 ± 11 versus 28 ± 4 nmol/h 100g body weight, P < 0.02). In contrast to zinc sulfate, treatment with zinc methacrylate did not lead to the elevation of serum zinc levels.
Conclusions:
Oral administration of zinc salts efficiently decreased serum bilirubin levels in hyperbilirubinemic rats, presumably as a result of inhibition of enterohepatic circulation of bilirubin. This approach might be useful in the treatment of severe unconjugated hyperbilirubinemias. |
| doi_str_mv | 10.1002/j.1536-4801.2005.tb00952.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67418667</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67418667</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3820-1e36fd6be2531f113e0f0e264cff6773bdbe90999a282df798a485278472725c3</originalsourceid><addsrcrecordid>eNqVkU1v1DAQhi0EokvhLyALCW4JYye2Y2501dKi5UO0XLhYjneszeJstnZCu_--iTbQMwd_SH7emdFjQt4wyBkAf7_NmShkVlbAcg4g8r4G0ILn90_I4t_TU7IArlTGGZMn5EVKWwBQpYDn5IQJqbWsxIJ8udkgPfceXU87T381O0evbegT7Xb0GuPQ0rMmNHGomx1d4R8MiY63y8MeY_33AdvG0R-2Ty_JM29DwlfzeUp-XpzfLC-z1bdPV8uPq8wVFYeMYSH9WtbIRcE8YwWCB-SydN5LpYp6XaMGrbXlFV97pStbVoKrqlRcceGKU_LuWHcfu9sBU2_aJjkMwe6wG5KRqmSVlGoEPxxBF7uUInqzj01r48EwMJNMszWTMTMZM5NMM8s092P49dxlqFtcP0ZneyPwdgZscjb4aHeuSY-cnKqyaYryyN11oceYfofhDqPZ4Ch6Y8ZvAcGUzKb2MG6QjYvBGFvOsSbg4T8mN5-_fy3OLoBrrosHvU2giA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67418667</pqid></control><display><type>article</type><title>The Effect of Zinc Salts on Serum Bilirubin Levels in Hyperbilirubinemic Rats</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Journals@Ovid Ovid Autoload</source><creator>Vítek, Libor ; Muchová, Lucie ; Zelenka, Jaroslav ; Zadinová, Marie ; Malina, Jiří</creator><creatorcontrib>Vítek, Libor ; Muchová, Lucie ; Zelenka, Jaroslav ; Zadinová, Marie ; Malina, Jiří</creatorcontrib><description>ABSTRACT
Objectives:
Intestinal metabolism of bilirubin is implicated in the pathogenesis of neonatal jaundice and Crigler‐Najjar syndrome. In the present study the authors investigated the effect of oral administration of zinc salts on serum bilirubin levels in hyperbilirubinemic rats.
Methods:
Bilirubin‐binding activities of zinc sulfate and water‐insoluble zinc methacrylate were determined in vitro. Congenitally hyperbilirubinemic Gunn rats and artificially hyperbilirubinemic Wistar rats were used in in vivo studies. Animals were fed a normal diet for 1 week and then a treatment diet of either zinc sulfate or zinc methacrylate for additional 2 weeks. Serum and fecal bile pigments were determined at the end of each phase. Biliary bilirubin secretion rates were determined in hyperbilirubinemic Wistar rats fed zinc methacrylate.
Results:
Substantial bilirubin‐binding activities of zinc salts were demonstrated in in vitro experiments. Treatment with oral zinc salts significantly decreased serum bilirubin levels in Gunn rats (166 ± 53 versus 123 ± 38 and 206 ± 34 versus 131 ± 31 μmol/L, P < 0.05 for zinc methacrylate and zinc sulfate, respectively). A similar effect of zinc methacrylate was also observed in hyperbilirubinemic Wistar rats (102 ± 10 versus 14 ± 4 μmol/L, P < 0.0001). In accord, biliary bilirubin secretion decreased significantly in these animals (45 ± 11 versus 28 ± 4 nmol/h 100g body weight, P < 0.02). In contrast to zinc sulfate, treatment with zinc methacrylate did not lead to the elevation of serum zinc levels.
Conclusions:
Oral administration of zinc salts efficiently decreased serum bilirubin levels in hyperbilirubinemic rats, presumably as a result of inhibition of enterohepatic circulation of bilirubin. This approach might be useful in the treatment of severe unconjugated hyperbilirubinemias.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1002/j.1536-4801.2005.tb00952.x</identifier><identifier>PMID: 15699685</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Administration, Oral ; Animals ; Astringents ; Bile Acids and Salts - analysis ; bilirubin ; Bilirubin - pharmacokinetics ; Biological and medical sciences ; Crigler-Najjar Syndrome - drug therapy ; Crigler‐Najjar syndrome ; Disease Models, Animal ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Gunn rats ; Humans ; Hyperbilirubinemia - blood ; Hyperbilirubinemia - drug therapy ; Male ; Methacrylates - administration & dosage ; Methacrylates - pharmacology ; neonatal jaundice ; Rats ; Rats, Gunn ; Rats, Wistar ; Solubility ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; zinc salts ; Zinc Sulfate - administration & dosage ; Zinc Sulfate - pharmacology</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 2005-02, Vol.40 (2), p.135-140</ispartof><rights>2005 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>2005 Lippincott Williams & Wilkins, Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3820-1e36fd6be2531f113e0f0e264cff6773bdbe90999a282df798a485278472725c3</citedby><cites>FETCH-LOGICAL-c3820-1e36fd6be2531f113e0f0e264cff6773bdbe90999a282df798a485278472725c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fj.1536-4801.2005.tb00952.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fj.1536-4801.2005.tb00952.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16480117$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15699685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vítek, Libor</creatorcontrib><creatorcontrib>Muchová, Lucie</creatorcontrib><creatorcontrib>Zelenka, Jaroslav</creatorcontrib><creatorcontrib>Zadinová, Marie</creatorcontrib><creatorcontrib>Malina, Jiří</creatorcontrib><title>The Effect of Zinc Salts on Serum Bilirubin Levels in Hyperbilirubinemic Rats</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>ABSTRACT
Objectives:
Intestinal metabolism of bilirubin is implicated in the pathogenesis of neonatal jaundice and Crigler‐Najjar syndrome. In the present study the authors investigated the effect of oral administration of zinc salts on serum bilirubin levels in hyperbilirubinemic rats.
Methods:
Bilirubin‐binding activities of zinc sulfate and water‐insoluble zinc methacrylate were determined in vitro. Congenitally hyperbilirubinemic Gunn rats and artificially hyperbilirubinemic Wistar rats were used in in vivo studies. Animals were fed a normal diet for 1 week and then a treatment diet of either zinc sulfate or zinc methacrylate for additional 2 weeks. Serum and fecal bile pigments were determined at the end of each phase. Biliary bilirubin secretion rates were determined in hyperbilirubinemic Wistar rats fed zinc methacrylate.
Results:
Substantial bilirubin‐binding activities of zinc salts were demonstrated in in vitro experiments. Treatment with oral zinc salts significantly decreased serum bilirubin levels in Gunn rats (166 ± 53 versus 123 ± 38 and 206 ± 34 versus 131 ± 31 μmol/L, P < 0.05 for zinc methacrylate and zinc sulfate, respectively). A similar effect of zinc methacrylate was also observed in hyperbilirubinemic Wistar rats (102 ± 10 versus 14 ± 4 μmol/L, P < 0.0001). In accord, biliary bilirubin secretion decreased significantly in these animals (45 ± 11 versus 28 ± 4 nmol/h 100g body weight, P < 0.02). In contrast to zinc sulfate, treatment with zinc methacrylate did not lead to the elevation of serum zinc levels.
Conclusions:
Oral administration of zinc salts efficiently decreased serum bilirubin levels in hyperbilirubinemic rats, presumably as a result of inhibition of enterohepatic circulation of bilirubin. This approach might be useful in the treatment of severe unconjugated hyperbilirubinemias.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Astringents</subject><subject>Bile Acids and Salts - analysis</subject><subject>bilirubin</subject><subject>Bilirubin - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Crigler-Najjar Syndrome - drug therapy</subject><subject>Crigler‐Najjar syndrome</subject><subject>Disease Models, Animal</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gunn rats</subject><subject>Humans</subject><subject>Hyperbilirubinemia - blood</subject><subject>Hyperbilirubinemia - drug therapy</subject><subject>Male</subject><subject>Methacrylates - administration & dosage</subject><subject>Methacrylates - pharmacology</subject><subject>neonatal jaundice</subject><subject>Rats</subject><subject>Rats, Gunn</subject><subject>Rats, Wistar</subject><subject>Solubility</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>zinc salts</subject><subject>Zinc Sulfate - administration & dosage</subject><subject>Zinc Sulfate - pharmacology</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkU1v1DAQhi0EokvhLyALCW4JYye2Y2501dKi5UO0XLhYjneszeJstnZCu_--iTbQMwd_SH7emdFjQt4wyBkAf7_NmShkVlbAcg4g8r4G0ILn90_I4t_TU7IArlTGGZMn5EVKWwBQpYDn5IQJqbWsxIJ8udkgPfceXU87T381O0evbegT7Xb0GuPQ0rMmNHGomx1d4R8MiY63y8MeY_33AdvG0R-2Ty_JM29DwlfzeUp-XpzfLC-z1bdPV8uPq8wVFYeMYSH9WtbIRcE8YwWCB-SydN5LpYp6XaMGrbXlFV97pStbVoKrqlRcceGKU_LuWHcfu9sBU2_aJjkMwe6wG5KRqmSVlGoEPxxBF7uUInqzj01r48EwMJNMszWTMTMZM5NMM8s092P49dxlqFtcP0ZneyPwdgZscjb4aHeuSY-cnKqyaYryyN11oceYfofhDqPZ4Ch6Y8ZvAcGUzKb2MG6QjYvBGFvOsSbg4T8mN5-_fy3OLoBrrosHvU2giA</recordid><startdate>200502</startdate><enddate>200502</enddate><creator>Vítek, Libor</creator><creator>Muchová, Lucie</creator><creator>Zelenka, Jaroslav</creator><creator>Zadinová, Marie</creator><creator>Malina, Jiří</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200502</creationdate><title>The Effect of Zinc Salts on Serum Bilirubin Levels in Hyperbilirubinemic Rats</title><author>Vítek, Libor ; Muchová, Lucie ; Zelenka, Jaroslav ; Zadinová, Marie ; Malina, Jiří</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3820-1e36fd6be2531f113e0f0e264cff6773bdbe90999a282df798a485278472725c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Astringents</topic><topic>Bile Acids and Salts - analysis</topic><topic>bilirubin</topic><topic>Bilirubin - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Crigler-Najjar Syndrome - drug therapy</topic><topic>Crigler‐Najjar syndrome</topic><topic>Disease Models, Animal</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gunn rats</topic><topic>Humans</topic><topic>Hyperbilirubinemia - blood</topic><topic>Hyperbilirubinemia - drug therapy</topic><topic>Male</topic><topic>Methacrylates - administration & dosage</topic><topic>Methacrylates - pharmacology</topic><topic>neonatal jaundice</topic><topic>Rats</topic><topic>Rats, Gunn</topic><topic>Rats, Wistar</topic><topic>Solubility</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>zinc salts</topic><topic>Zinc Sulfate - administration & dosage</topic><topic>Zinc Sulfate - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vítek, Libor</creatorcontrib><creatorcontrib>Muchová, Lucie</creatorcontrib><creatorcontrib>Zelenka, Jaroslav</creatorcontrib><creatorcontrib>Zadinová, Marie</creatorcontrib><creatorcontrib>Malina, Jiří</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vítek, Libor</au><au>Muchová, Lucie</au><au>Zelenka, Jaroslav</au><au>Zadinová, Marie</au><au>Malina, Jiří</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Zinc Salts on Serum Bilirubin Levels in Hyperbilirubinemic Rats</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>2005-02</date><risdate>2005</risdate><volume>40</volume><issue>2</issue><spage>135</spage><epage>140</epage><pages>135-140</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>ABSTRACT
Objectives:
Intestinal metabolism of bilirubin is implicated in the pathogenesis of neonatal jaundice and Crigler‐Najjar syndrome. In the present study the authors investigated the effect of oral administration of zinc salts on serum bilirubin levels in hyperbilirubinemic rats.
Methods:
Bilirubin‐binding activities of zinc sulfate and water‐insoluble zinc methacrylate were determined in vitro. Congenitally hyperbilirubinemic Gunn rats and artificially hyperbilirubinemic Wistar rats were used in in vivo studies. Animals were fed a normal diet for 1 week and then a treatment diet of either zinc sulfate or zinc methacrylate for additional 2 weeks. Serum and fecal bile pigments were determined at the end of each phase. Biliary bilirubin secretion rates were determined in hyperbilirubinemic Wistar rats fed zinc methacrylate.
Results:
Substantial bilirubin‐binding activities of zinc salts were demonstrated in in vitro experiments. Treatment with oral zinc salts significantly decreased serum bilirubin levels in Gunn rats (166 ± 53 versus 123 ± 38 and 206 ± 34 versus 131 ± 31 μmol/L, P < 0.05 for zinc methacrylate and zinc sulfate, respectively). A similar effect of zinc methacrylate was also observed in hyperbilirubinemic Wistar rats (102 ± 10 versus 14 ± 4 μmol/L, P < 0.0001). In accord, biliary bilirubin secretion decreased significantly in these animals (45 ± 11 versus 28 ± 4 nmol/h 100g body weight, P < 0.02). In contrast to zinc sulfate, treatment with zinc methacrylate did not lead to the elevation of serum zinc levels.
Conclusions:
Oral administration of zinc salts efficiently decreased serum bilirubin levels in hyperbilirubinemic rats, presumably as a result of inhibition of enterohepatic circulation of bilirubin. This approach might be useful in the treatment of severe unconjugated hyperbilirubinemias.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>15699685</pmid><doi>10.1002/j.1536-4801.2005.tb00952.x</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Journals@Ovid Ovid Autoload |
| subjects | Administration, Oral Animals Astringents Bile Acids and Salts - analysis bilirubin Bilirubin - pharmacokinetics Biological and medical sciences Crigler-Najjar Syndrome - drug therapy Crigler‐Najjar syndrome Disease Models, Animal Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gunn rats Humans Hyperbilirubinemia - blood Hyperbilirubinemia - drug therapy Male Methacrylates - administration & dosage Methacrylates - pharmacology neonatal jaundice Rats Rats, Gunn Rats, Wistar Solubility Vertebrates: anatomy and physiology, studies on body, several organs or systems zinc salts Zinc Sulfate - administration & dosage Zinc Sulfate - pharmacology |
| title | The Effect of Zinc Salts on Serum Bilirubin Levels in Hyperbilirubinemic Rats |
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