Pioglitazone, a peroxisome proliferator-activated receptor γ activator, ameliorates experimental autoimmune myocarditis by modulating Th1/Th2 balance

Objectives – The aim of this study is to investigate the effect of Peroxisome proliferator-activated receptor γ (PPARγ) ligand on experimental autoimmune myocarditis (EAM). Background – Rat EAM model resembles the giant cell myocarditis in human. Recent studies have suggested that Th1 cytokines are...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2005-02, Vol.38 (2), p.257-265
Hauptverfasser:	Hasegawa, Hiroshi, Takano, Hiroyuki, Zou, Yunzeng, Qin, Yingjie, Hizukuri, Kaoru, Odaka, Kenichi, Toyozaki, Tetsuya, Komuro, Issei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune Diseases - immunology Autoimmune Diseases - pathology Autoimmune Diseases - physiopathology Body Weight - drug effects Cytokine Cytokines - genetics Cytokines - metabolism Disease Models, Animal Female Helper T cell Hemodynamics Myocarditis Myocarditis - immunology Myocarditis - metabolism Myocarditis - pathology Myocarditis - physiopathology Organ Size - drug effects Peroxisome proliferator-activated receptor γ Pioglitazone PPAR gamma - agonists PPAR gamma - metabolism Rats RNA, Messenger - genetics RNA, Messenger - metabolism Th1 Cells - drug effects Th1 Cells - immunology Th1 Cells - metabolism Th2 Cells - drug effects Th2 Cells - immunology Th2 Cells - metabolism Thiazolidinediones - pharmacology
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