Routine Early Angioplasty after Fibrinolysis for Acute Myocardial Infarction
In a randomized trial, 1059 patients with an acute myocardial infarction with ST-segment elevation presented to hospitals that did not have the capability of performing percutaneous coronary intervention (PCI) and received fibrinolysis. They were then assigned to either immediate transfer to a PCI c...
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| Veröffentlicht in: | The New England journal of medicine 2009-06, Vol.360 (26), p.2705-2718 |
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| creator | Cantor, Warren J Fitchett, David Borgundvaag, Bjug Ducas, John Heffernan, Michael Cohen, Eric A Morrison, Laurie J Langer, Anatoly Dzavik, Vladimir Mehta, Shamir R Lazzam, Charles Schwartz, Brian Casanova, Amparo Goodman, Shaun G |
| description | In a randomized trial, 1059 patients with an acute myocardial infarction with ST-segment elevation presented to hospitals that did not have the capability of performing percutaneous coronary intervention (PCI) and received fibrinolysis. They were then assigned to either immediate transfer to a PCI center for catheterization or transfer only if fibrinolysis failed. The immediate-transfer strategy was associated with significantly fewer ischemic complications at 30 days.
In patients with an acute myocardial infarction with ST-segment elevation, routine early angioplasty after fibrinolysis was associated with significantly fewer ischemic complications at 30 days.
Primary percutaneous coronary intervention (PCI) is an effective treatment for myocardial infarction with ST-segment elevation when it can be performed rapidly.
1
However, primary PCI is performed at less than 25% of acute care hospitals in the United States.
2
,
3
Many patients with myocardial infarction with ST-segment elevation present to hospitals that do not have the capability of performing PCI and therefore cannot undergo PCI within the timelines recommended in the guidelines
4
; instead, they receive fibrinolysis as the initial reperfusion therapy. Although the proportion of such patients has decreased in recent years, 27.6% of the patients in the National Registry . . . |
| doi_str_mv | 10.1056/NEJMoa0808276 |
| format | Article |
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In patients with an acute myocardial infarction with ST-segment elevation, routine early angioplasty after fibrinolysis was associated with significantly fewer ischemic complications at 30 days.
Primary percutaneous coronary intervention (PCI) is an effective treatment for myocardial infarction with ST-segment elevation when it can be performed rapidly.
1
However, primary PCI is performed at less than 25% of acute care hospitals in the United States.
2
,
3
Many patients with myocardial infarction with ST-segment elevation present to hospitals that do not have the capability of performing PCI and therefore cannot undergo PCI within the timelines recommended in the guidelines
4
; instead, they receive fibrinolysis as the initial reperfusion therapy. Although the proportion of such patients has decreased in recent years, 27.6% of the patients in the National Registry . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa0808276</identifier><identifier>PMID: 19553646</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Waltham, MA: Massachusetts Medical Society</publisher><subject>Aged ; Angioplasty, Balloon, Coronary ; Biological and medical sciences ; Cardiac Catheterization ; Combined Modality Therapy ; Coronary Angiography ; Data analysis ; Data collection ; Diseases of the cardiovascular system ; Female ; Fibrinolytic Agents - therapeutic use ; General aspects ; Heart attacks ; Heart Failure - etiology ; Heart surgery ; Humans ; Kaplan-Meier Estimate ; Male ; Medical imaging ; Medical research ; Medical sciences ; Middle Aged ; Myocardial Infarction - complications ; Myocardial Infarction - drug therapy ; Myocardial Infarction - mortality ; Myocardial Infarction - therapy ; Patient Transfer ; Platelet Aggregation Inhibitors - therapeutic use ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Recurrence ; Shock, Cardiogenic - etiology ; Thrombolytic Therapy ; Time Factors</subject><ispartof>The New England journal of medicine, 2009-06, Vol.360 (26), p.2705-2718</ispartof><rights>Copyright © 2009 Massachusetts Medical Society. All rights reserved.</rights><rights>2009 INIST-CNRS</rights><rights>2009 Massachusetts Medical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-f3638d0444b67557774899f14f35eb222946259f94c84239b952a91c0276ab803</citedby><cites>FETCH-LOGICAL-c533t-f3638d0444b67557774899f14f35eb222946259f94c84239b952a91c0276ab803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa0808276$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223907654?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,2746,2747,26084,27905,27906,52363,54045,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21718930$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19553646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cantor, Warren J</creatorcontrib><creatorcontrib>Fitchett, David</creatorcontrib><creatorcontrib>Borgundvaag, Bjug</creatorcontrib><creatorcontrib>Ducas, John</creatorcontrib><creatorcontrib>Heffernan, Michael</creatorcontrib><creatorcontrib>Cohen, Eric A</creatorcontrib><creatorcontrib>Morrison, Laurie J</creatorcontrib><creatorcontrib>Langer, Anatoly</creatorcontrib><creatorcontrib>Dzavik, Vladimir</creatorcontrib><creatorcontrib>Mehta, Shamir R</creatorcontrib><creatorcontrib>Lazzam, Charles</creatorcontrib><creatorcontrib>Schwartz, Brian</creatorcontrib><creatorcontrib>Casanova, Amparo</creatorcontrib><creatorcontrib>Goodman, Shaun G</creatorcontrib><creatorcontrib>TRANSFER-AMI Trial Investigators</creatorcontrib><title>Routine Early Angioplasty after Fibrinolysis for Acute Myocardial Infarction</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In a randomized trial, 1059 patients with an acute myocardial infarction with ST-segment elevation presented to hospitals that did not have the capability of performing percutaneous coronary intervention (PCI) and received fibrinolysis. They were then assigned to either immediate transfer to a PCI center for catheterization or transfer only if fibrinolysis failed. The immediate-transfer strategy was associated with significantly fewer ischemic complications at 30 days.
In patients with an acute myocardial infarction with ST-segment elevation, routine early angioplasty after fibrinolysis was associated with significantly fewer ischemic complications at 30 days.
Primary percutaneous coronary intervention (PCI) is an effective treatment for myocardial infarction with ST-segment elevation when it can be performed rapidly.
1
However, primary PCI is performed at less than 25% of acute care hospitals in the United States.
2
,
3
Many patients with myocardial infarction with ST-segment elevation present to hospitals that do not have the capability of performing PCI and therefore cannot undergo PCI within the timelines recommended in the guidelines
4
; instead, they receive fibrinolysis as the initial reperfusion therapy. Although the proportion of such patients has decreased in recent years, 27.6% of the patients in the National Registry . . .</description><subject>Aged</subject><subject>Angioplasty, Balloon, Coronary</subject><subject>Biological and medical sciences</subject><subject>Cardiac Catheterization</subject><subject>Combined Modality Therapy</subject><subject>Coronary Angiography</subject><subject>Data analysis</subject><subject>Data collection</subject><subject>Diseases of the cardiovascular system</subject><subject>Female</subject><subject>Fibrinolytic Agents - therapeutic use</subject><subject>General aspects</subject><subject>Heart attacks</subject><subject>Heart Failure - etiology</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Myocardial Infarction - mortality</subject><subject>Myocardial Infarction - therapy</subject><subject>Patient Transfer</subject><subject>Platelet Aggregation Inhibitors - therapeutic use</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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They were then assigned to either immediate transfer to a PCI center for catheterization or transfer only if fibrinolysis failed. The immediate-transfer strategy was associated with significantly fewer ischemic complications at 30 days.
In patients with an acute myocardial infarction with ST-segment elevation, routine early angioplasty after fibrinolysis was associated with significantly fewer ischemic complications at 30 days.
Primary percutaneous coronary intervention (PCI) is an effective treatment for myocardial infarction with ST-segment elevation when it can be performed rapidly.
1
However, primary PCI is performed at less than 25% of acute care hospitals in the United States.
2
,
3
Many patients with myocardial infarction with ST-segment elevation present to hospitals that do not have the capability of performing PCI and therefore cannot undergo PCI within the timelines recommended in the guidelines
4
; instead, they receive fibrinolysis as the initial reperfusion therapy. Although the proportion of such patients has decreased in recent years, 27.6% of the patients in the National Registry . . .</abstract><cop>Waltham, MA</cop><pub>Massachusetts Medical Society</pub><pmid>19553646</pmid><doi>10.1056/NEJMoa0808276</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2009-06, Vol.360 (26), p.2705-2718 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67418102 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Aged Angioplasty, Balloon, Coronary Biological and medical sciences Cardiac Catheterization Combined Modality Therapy Coronary Angiography Data analysis Data collection Diseases of the cardiovascular system Female Fibrinolytic Agents - therapeutic use General aspects Heart attacks Heart Failure - etiology Heart surgery Humans Kaplan-Meier Estimate Male Medical imaging Medical research Medical sciences Middle Aged Myocardial Infarction - complications Myocardial Infarction - drug therapy Myocardial Infarction - mortality Myocardial Infarction - therapy Patient Transfer Platelet Aggregation Inhibitors - therapeutic use Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Recurrence Shock, Cardiogenic - etiology Thrombolytic Therapy Time Factors |
| title | Routine Early Angioplasty after Fibrinolysis for Acute Myocardial Infarction |
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