Progressive methylation during the serrated neoplasia pathway of the colorectum

Serrated adenoma is a recently described entity characterized by having combined architectural features of hyperplastic polyps and classical adenoma. To understand the role of gene regulation in the progression of the serrated neoplasia pathway, we examined the methylation profiles of the promoter r...

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Veröffentlicht in:	Modern pathology 2005-02, Vol.18 (2), p.170-178
Hauptverfasser:	Dong, Seung M, Lee, Eui J, Jeon, Eun S, Park, Cheol K, Kim, Kyoung-Mee
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - genetics Adenoma - pathology Adult Aged Aged, 80 and over Analysis of Variance Biomarkers, Tumor - genetics Cancer Cell cycle Chi-Square Distribution Colonic Polyps - genetics Colonic Polyps - pathology Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology CpG Islands - genetics Disease Progression DNA Methylation Female Genes Genotype & phenotype Humans Hyperplasia - genetics Hyperplasia - pathology Laboratory Medicine Male Medicine Medicine & Public Health methylation Microsatellite Repeats - genetics Middle Aged Mutation original-article Pathology Ploidies Polyps Promoter Regions, Genetic - genetics serrated adenomas tumor suppressor genes Tumorigenesis Tumors
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