Fibroblast Growth Factor Receptor 3 Is Overexpressed in Urinary Tract Carcinomas and Modulates the Neoplastic Cell Growth

Purpose: Fibroblast growth factor receptor 3 ( FGFR3 ) mutations have been associated with achondroplastic syndromes and urinary bladder carcinomas. Here we describe changes in FGFR3 mRNA and protein expression in transitional carcinomas and determine the effect of monoclonal antibodies against FGFR...

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Veröffentlicht in:	Clinical cancer research 2005-01, Vol.11 (2), p.459-465
Hauptverfasser:	GOMEZ-ROMAN, J. Javier, SAENZ, Pilar, ESPARZA, Clara, VAL-BERNAL, J. Fernando, CUEVAS GONZALEZ, Jorge, ESCUREDO, Kepa, SANTA CRUZ, Simon, JUNQUERA, Corina, SIMON, Laureano, MARTINEZ, Antonio, GUTIERREZ BANOS, J. Luis, LOPEZ-BREA, Marta
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - pharmacology Antineoplastic agents Biological and medical sciences Biomarkers, Tumor Blotting, Western Carcinoma, Transitional Cell - metabolism Carcinoma, Transitional Cell - pathology Cell Proliferation FGFR3 Fibroblast Growth Factors - genetics Fibroblast Growth Factors - metabolism Gene Expression Profiling Humans Immunoenzyme Techniques Medical sciences Neoplasm Invasiveness - pathology Neoplasm Staging Oligonucleotide Array Sequence Analysis Pharmacology. Drug treatments Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Receptor, Fibroblast Growth Factor, Type 3 Receptors, Fibroblast Growth Factor - genetics Receptors, Fibroblast Growth Factor - metabolism RNA, Messenger - metabolism Transitional carcinoma Tumor Cells, Cultured Up-Regulation Urinary bladder Urinary Bladder - metabolism Urinary Bladder - pathology Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology
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