Purification, Pharmacological Modulation, and Biochemical Characterization of Interactors of Endogenous Human γ-Secretase

γ-Secretase is a unique intramembrane-cleaving protease complex, which cleaves the Alzheimer′s disease-associated β-amyloid precursor protein (APP) and a number of other type I membrane proteins. Human γ-secretase consists of the catalytic subunit presenilin (PS) (PS1 or PS2), the substrate receptor...

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Veröffentlicht in:	Biochemistry (Easton) 2009-02, Vol.48 (6), p.1183-1197
Hauptverfasser:	Winkler, Edith, Hobson, Scott, Fukumori, Akio, Dümpelfeld, Birgit, Luebbers, Thomas, Baumann, Karlheinz, Haass, Christian, Hopf, Carsten, Steiner, Harald
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - chemistry Amyloid Precursor Protein Secretases - isolation & purification Amyloid Precursor Protein Secretases - metabolism Biotinylation - drug effects Cell Line Chromatography, Affinity Chromatography, Liquid Electrophoresis, Polyacrylamide Gel Enzyme Inhibitors - pharmacology Humans Molecular Weight Multiprotein Complexes - metabolism Mutant Proteins - metabolism Protein Binding - drug effects Protein Subunits - metabolism Substrate Specificity - drug effects Tandem Mass Spectrometry
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