The association between dietary vitamin K intake and serum undercarboxylated osteocalcin is modulated by vitamin K epoxide reductase genotype
Vitamin K acts as a cofactor during the γ-carboxylation of vitamin K-dependent proteins. Undercarboxylated osteocalcin (ucOC) is a suggested biomarker of vitamin K status. The +2255 polymorphism of the vitamin K epoxide reductase gene (VKORC1) was shown to be associated with the recycling rate of th...
Gespeichert in:
| Veröffentlicht in: | British journal of nutrition 2009-06, Vol.101 (12), p.1812-1820 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1820 |
|---|---|
| container_issue | 12 |
| container_start_page | 1812 |
| container_title | British journal of nutrition |
| container_volume | 101 |
| creator | Nimptsch, Katharina Nieters, Alexandra Hailer, Susanne Wolfram, Günther Linseisen, Jakob |
| description | Vitamin K acts as a cofactor during the γ-carboxylation of vitamin K-dependent proteins. Undercarboxylated osteocalcin (ucOC) is a suggested biomarker of vitamin K status. The +2255 polymorphism of the vitamin K epoxide reductase gene (VKORC1) was shown to be associated with the recycling rate of the active form of vitamin K. We investigated the association between dietary vitamin K intake and serum ucOC and hypothesized that this association might vary by VKORC1 genotype. ucOC and total intact osteocalcin (iOC) concentrations were quantified using specific ELISA tests in serum samples of 548 male and female participants (aged 18–81 years) of the Bavarian Food Consumption Survey II. ucOC was expressed relative to iOC (ucOC/iOC ratio). Dietary intake of vitamin K (phylloquinone and menaquinones) was estimated from three 24 h dietary recalls using previously published food composition data. The association between dietary vitamin K intake and ucOC/iOC ratio was analysed using linear and non-linear regression models. Median intakes of phylloquinone/menaquinones were 83·4/37·6 μg/d in men and 79·6/29·8 μg/d in women, respectively. As expected, vitamin K intake was significantly inversely associated with the ucOC/iOC ratio. The ucOC/iOC ratio differed significantly across variants of the +2255 polymorphism in the VKORC1 gene. Stratification by VKORC1+2255 genotype revealed that only in carriers of the GG genotype (39 % of all participants) did the ucOC/iOC ratio significantly decrease with increasing intake of vitamin K. Thus, the results show that the inverse association between dietary vitamin K intake and serum ucOC depends on a functionally relevant allelic variant of the VKORC1 gene. |
| doi_str_mv | 10.1017/S0007114508131750 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67414531</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0007114508131750</cupid><sourcerecordid>67414531</sourcerecordid><originalsourceid>FETCH-LOGICAL-c536t-5449f68f1aee8757d4424de013f08ba6ea42fc4adc4189fd3b04bacfa58dcb03</originalsourceid><addsrcrecordid>eNqFkc2O0zAUhSMEYsrAA7ABCwl2AdvxT7pEFQxoRvxoytq6sW-KZ5q42A60D8E746rVDAIhVpF1vnuUc05VPWb0JaNMv7qklGrGhKQta5iW9E41Y0LLmivF71azvVzv9ZPqQUpX5dkyOr9fnbA55VJzOat-Lr8igZSC9ZB9GEmH-QfiSJzHDHFHvvsMgx_JOfFjhusCj44kjNNAptFhtBC7sN2tIaMjIWUMFta2HPhEhuCmg9D9boSbsPUOSUQ32QwJyQrHkHcbfFjd62Gd8NHxe1ot375ZLt7VFx_P3i9eX9RWNirXUoh5r9qeAWKrpXZCcOGQsqanbQcKQfDeCnBWsHbeu6ajogPbg2yd7WhzWr042G5i-DZhymbwyeJ6DSOGKRmlRSmtYf8FeSmYzjUv4LM_wKswxbFkMJw1LW81EwViB8jGkFLE3myiH0rJhlGzH9T8NWi5eXI0nroB3e3FccECPD8CkErzfYTR-nTDcaZUK6kqXH3gfNloe6NDvC5xGy2NOvtszhfNh09UKaML__TA9xAMrGLx_HLJS8WUKakbtv-15hgHhi56t8Lb0P8O9Atx8NHU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213828714</pqid></control><display><type>article</type><title>The association between dietary vitamin K intake and serum undercarboxylated osteocalcin is modulated by vitamin K epoxide reductase genotype</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><source>Cambridge University Press Journals Complete</source><creator>Nimptsch, Katharina ; Nieters, Alexandra ; Hailer, Susanne ; Wolfram, Günther ; Linseisen, Jakob</creator><creatorcontrib>Nimptsch, Katharina ; Nieters, Alexandra ; Hailer, Susanne ; Wolfram, Günther ; Linseisen, Jakob</creatorcontrib><description>Vitamin K acts as a cofactor during the γ-carboxylation of vitamin K-dependent proteins. Undercarboxylated osteocalcin (ucOC) is a suggested biomarker of vitamin K status. The +2255 polymorphism of the vitamin K epoxide reductase gene (VKORC1) was shown to be associated with the recycling rate of the active form of vitamin K. We investigated the association between dietary vitamin K intake and serum ucOC and hypothesized that this association might vary by VKORC1 genotype. ucOC and total intact osteocalcin (iOC) concentrations were quantified using specific ELISA tests in serum samples of 548 male and female participants (aged 18–81 years) of the Bavarian Food Consumption Survey II. ucOC was expressed relative to iOC (ucOC/iOC ratio). Dietary intake of vitamin K (phylloquinone and menaquinones) was estimated from three 24 h dietary recalls using previously published food composition data. The association between dietary vitamin K intake and ucOC/iOC ratio was analysed using linear and non-linear regression models. Median intakes of phylloquinone/menaquinones were 83·4/37·6 μg/d in men and 79·6/29·8 μg/d in women, respectively. As expected, vitamin K intake was significantly inversely associated with the ucOC/iOC ratio. The ucOC/iOC ratio differed significantly across variants of the +2255 polymorphism in the VKORC1 gene. Stratification by VKORC1+2255 genotype revealed that only in carriers of the GG genotype (39 % of all participants) did the ucOC/iOC ratio significantly decrease with increasing intake of vitamin K. Thus, the results show that the inverse association between dietary vitamin K intake and serum ucOC depends on a functionally relevant allelic variant of the VKORC1 gene.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114508131750</identifier><identifier>PMID: 19025725</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adolescent ; Adult ; adults ; Aged ; Aged, 80 and over ; Bavarian Food Consumption Survey II ; Biological and medical sciences ; biomarkers ; Biomarkers - blood ; Bone density ; Coagulation ; Cross-Sectional Studies ; Diet ; diet recall ; Diet Surveys ; dietary protein ; Dietary Surveys and Nutritional Epidemiology ; enzyme-linked immunosorbent assay ; epoxides ; Feeding. Feeding behavior ; Female ; food composition ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; genetic polymorphism ; Genotype ; Genotype & phenotype ; Germany ; human genetics ; Humans ; Linear Models ; Male ; men ; Menaquinones ; Middle Aged ; Mixed Function Oxygenases - genetics ; nutrient intake ; Nutrition ; nutrition-genotype interaction ; osteocalcin ; Osteocalcin - blood ; Phylloquinone ; Polymorphism, Genetic ; risk groups ; Sex Distribution ; Studies ; Undercarboxylated osteocalcin ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin K ; Vitamin K - administration & dosage ; Vitamin K 1 - administration & dosage ; Vitamin K 2 - administration & dosage ; Vitamin K Epoxide Reductases ; Vitamins ; Vitamins - administration & dosage ; women</subject><ispartof>British journal of nutrition, 2009-06, Vol.101 (12), p.1812-1820</ispartof><rights>Copyright © The Authors 2008</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-5449f68f1aee8757d4424de013f08ba6ea42fc4adc4189fd3b04bacfa58dcb03</citedby><cites>FETCH-LOGICAL-c536t-5449f68f1aee8757d4424de013f08ba6ea42fc4adc4189fd3b04bacfa58dcb03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114508131750/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,55628</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21668506$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19025725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nimptsch, Katharina</creatorcontrib><creatorcontrib>Nieters, Alexandra</creatorcontrib><creatorcontrib>Hailer, Susanne</creatorcontrib><creatorcontrib>Wolfram, Günther</creatorcontrib><creatorcontrib>Linseisen, Jakob</creatorcontrib><title>The association between dietary vitamin K intake and serum undercarboxylated osteocalcin is modulated by vitamin K epoxide reductase genotype</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Vitamin K acts as a cofactor during the γ-carboxylation of vitamin K-dependent proteins. Undercarboxylated osteocalcin (ucOC) is a suggested biomarker of vitamin K status. The +2255 polymorphism of the vitamin K epoxide reductase gene (VKORC1) was shown to be associated with the recycling rate of the active form of vitamin K. We investigated the association between dietary vitamin K intake and serum ucOC and hypothesized that this association might vary by VKORC1 genotype. ucOC and total intact osteocalcin (iOC) concentrations were quantified using specific ELISA tests in serum samples of 548 male and female participants (aged 18–81 years) of the Bavarian Food Consumption Survey II. ucOC was expressed relative to iOC (ucOC/iOC ratio). Dietary intake of vitamin K (phylloquinone and menaquinones) was estimated from three 24 h dietary recalls using previously published food composition data. The association between dietary vitamin K intake and ucOC/iOC ratio was analysed using linear and non-linear regression models. Median intakes of phylloquinone/menaquinones were 83·4/37·6 μg/d in men and 79·6/29·8 μg/d in women, respectively. As expected, vitamin K intake was significantly inversely associated with the ucOC/iOC ratio. The ucOC/iOC ratio differed significantly across variants of the +2255 polymorphism in the VKORC1 gene. Stratification by VKORC1+2255 genotype revealed that only in carriers of the GG genotype (39 % of all participants) did the ucOC/iOC ratio significantly decrease with increasing intake of vitamin K. Thus, the results show that the inverse association between dietary vitamin K intake and serum ucOC depends on a functionally relevant allelic variant of the VKORC1 gene.</description><subject>Adolescent</subject><subject>Adult</subject><subject>adults</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bavarian Food Consumption Survey II</subject><subject>Biological and medical sciences</subject><subject>biomarkers</subject><subject>Biomarkers - blood</subject><subject>Bone density</subject><subject>Coagulation</subject><subject>Cross-Sectional Studies</subject><subject>Diet</subject><subject>diet recall</subject><subject>Diet Surveys</subject><subject>dietary protein</subject><subject>Dietary Surveys and Nutritional Epidemiology</subject><subject>enzyme-linked immunosorbent assay</subject><subject>epoxides</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>food composition</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>genetic polymorphism</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Germany</subject><subject>human genetics</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Male</subject><subject>men</subject><subject>Menaquinones</subject><subject>Middle Aged</subject><subject>Mixed Function Oxygenases - genetics</subject><subject>nutrient intake</subject><subject>Nutrition</subject><subject>nutrition-genotype interaction</subject><subject>osteocalcin</subject><subject>Osteocalcin - blood</subject><subject>Phylloquinone</subject><subject>Polymorphism, Genetic</subject><subject>risk groups</subject><subject>Sex Distribution</subject><subject>Studies</subject><subject>Undercarboxylated osteocalcin</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin K</subject><subject>Vitamin K - administration & dosage</subject><subject>Vitamin K 1 - administration & dosage</subject><subject>Vitamin K 2 - administration & dosage</subject><subject>Vitamin K Epoxide Reductases</subject><subject>Vitamins</subject><subject>Vitamins - administration & dosage</subject><subject>women</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc2O0zAUhSMEYsrAA7ABCwl2AdvxT7pEFQxoRvxoytq6sW-KZ5q42A60D8E746rVDAIhVpF1vnuUc05VPWb0JaNMv7qklGrGhKQta5iW9E41Y0LLmivF71azvVzv9ZPqQUpX5dkyOr9fnbA55VJzOat-Lr8igZSC9ZB9GEmH-QfiSJzHDHFHvvsMgx_JOfFjhusCj44kjNNAptFhtBC7sN2tIaMjIWUMFta2HPhEhuCmg9D9boSbsPUOSUQ32QwJyQrHkHcbfFjd62Gd8NHxe1ot375ZLt7VFx_P3i9eX9RWNirXUoh5r9qeAWKrpXZCcOGQsqanbQcKQfDeCnBWsHbeu6ajogPbg2yd7WhzWr042G5i-DZhymbwyeJ6DSOGKRmlRSmtYf8FeSmYzjUv4LM_wKswxbFkMJw1LW81EwViB8jGkFLE3myiH0rJhlGzH9T8NWi5eXI0nroB3e3FccECPD8CkErzfYTR-nTDcaZUK6kqXH3gfNloe6NDvC5xGy2NOvtszhfNh09UKaML__TA9xAMrGLx_HLJS8WUKakbtv-15hgHhi56t8Lb0P8O9Atx8NHU</recordid><startdate>20090628</startdate><enddate>20090628</enddate><creator>Nimptsch, Katharina</creator><creator>Nieters, Alexandra</creator><creator>Hailer, Susanne</creator><creator>Wolfram, Günther</creator><creator>Linseisen, Jakob</creator><general>Cambridge University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20090628</creationdate><title>The association between dietary vitamin K intake and serum undercarboxylated osteocalcin is modulated by vitamin K epoxide reductase genotype</title><author>Nimptsch, Katharina ; Nieters, Alexandra ; Hailer, Susanne ; Wolfram, Günther ; Linseisen, Jakob</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-5449f68f1aee8757d4424de013f08ba6ea42fc4adc4189fd3b04bacfa58dcb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>adults</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bavarian Food Consumption Survey II</topic><topic>Biological and medical sciences</topic><topic>biomarkers</topic><topic>Biomarkers - blood</topic><topic>Bone density</topic><topic>Coagulation</topic><topic>Cross-Sectional Studies</topic><topic>Diet</topic><topic>diet recall</topic><topic>Diet Surveys</topic><topic>dietary protein</topic><topic>Dietary Surveys and Nutritional Epidemiology</topic><topic>enzyme-linked immunosorbent assay</topic><topic>epoxides</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>food composition</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>genetic polymorphism</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Germany</topic><topic>human genetics</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Male</topic><topic>men</topic><topic>Menaquinones</topic><topic>Middle Aged</topic><topic>Mixed Function Oxygenases - genetics</topic><topic>nutrient intake</topic><topic>Nutrition</topic><topic>nutrition-genotype interaction</topic><topic>osteocalcin</topic><topic>Osteocalcin - blood</topic><topic>Phylloquinone</topic><topic>Polymorphism, Genetic</topic><topic>risk groups</topic><topic>Sex Distribution</topic><topic>Studies</topic><topic>Undercarboxylated osteocalcin</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin K</topic><topic>Vitamin K - administration & dosage</topic><topic>Vitamin K 1 - administration & dosage</topic><topic>Vitamin K 2 - administration & dosage</topic><topic>Vitamin K Epoxide Reductases</topic><topic>Vitamins</topic><topic>Vitamins - administration & dosage</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nimptsch, Katharina</creatorcontrib><creatorcontrib>Nieters, Alexandra</creatorcontrib><creatorcontrib>Hailer, Susanne</creatorcontrib><creatorcontrib>Wolfram, Günther</creatorcontrib><creatorcontrib>Linseisen, Jakob</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nimptsch, Katharina</au><au>Nieters, Alexandra</au><au>Hailer, Susanne</au><au>Wolfram, Günther</au><au>Linseisen, Jakob</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between dietary vitamin K intake and serum undercarboxylated osteocalcin is modulated by vitamin K epoxide reductase genotype</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2009-06-28</date><risdate>2009</risdate><volume>101</volume><issue>12</issue><spage>1812</spage><epage>1820</epage><pages>1812-1820</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Vitamin K acts as a cofactor during the γ-carboxylation of vitamin K-dependent proteins. Undercarboxylated osteocalcin (ucOC) is a suggested biomarker of vitamin K status. The +2255 polymorphism of the vitamin K epoxide reductase gene (VKORC1) was shown to be associated with the recycling rate of the active form of vitamin K. We investigated the association between dietary vitamin K intake and serum ucOC and hypothesized that this association might vary by VKORC1 genotype. ucOC and total intact osteocalcin (iOC) concentrations were quantified using specific ELISA tests in serum samples of 548 male and female participants (aged 18–81 years) of the Bavarian Food Consumption Survey II. ucOC was expressed relative to iOC (ucOC/iOC ratio). Dietary intake of vitamin K (phylloquinone and menaquinones) was estimated from three 24 h dietary recalls using previously published food composition data. The association between dietary vitamin K intake and ucOC/iOC ratio was analysed using linear and non-linear regression models. Median intakes of phylloquinone/menaquinones were 83·4/37·6 μg/d in men and 79·6/29·8 μg/d in women, respectively. As expected, vitamin K intake was significantly inversely associated with the ucOC/iOC ratio. The ucOC/iOC ratio differed significantly across variants of the +2255 polymorphism in the VKORC1 gene. Stratification by VKORC1+2255 genotype revealed that only in carriers of the GG genotype (39 % of all participants) did the ucOC/iOC ratio significantly decrease with increasing intake of vitamin K. Thus, the results show that the inverse association between dietary vitamin K intake and serum ucOC depends on a functionally relevant allelic variant of the VKORC1 gene.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>19025725</pmid><doi>10.1017/S0007114508131750</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1145 |
| ispartof | British journal of nutrition, 2009-06, Vol.101 (12), p.1812-1820 |
| issn | 0007-1145 1475-2662 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67414531 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry; Cambridge University Press Journals Complete |
| subjects | Adolescent Adult adults Aged Aged, 80 and over Bavarian Food Consumption Survey II Biological and medical sciences biomarkers Biomarkers - blood Bone density Coagulation Cross-Sectional Studies Diet diet recall Diet Surveys dietary protein Dietary Surveys and Nutritional Epidemiology enzyme-linked immunosorbent assay epoxides Feeding. Feeding behavior Female food composition Fundamental and applied biological sciences. Psychology Gene Frequency genetic polymorphism Genotype Genotype & phenotype Germany human genetics Humans Linear Models Male men Menaquinones Middle Aged Mixed Function Oxygenases - genetics nutrient intake Nutrition nutrition-genotype interaction osteocalcin Osteocalcin - blood Phylloquinone Polymorphism, Genetic risk groups Sex Distribution Studies Undercarboxylated osteocalcin Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin K Vitamin K - administration & dosage Vitamin K 1 - administration & dosage Vitamin K 2 - administration & dosage Vitamin K Epoxide Reductases Vitamins Vitamins - administration & dosage women |
| title | The association between dietary vitamin K intake and serum undercarboxylated osteocalcin is modulated by vitamin K epoxide reductase genotype |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T05%3A34%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20association%20between%20dietary%20vitamin%20K%20intake%20and%20serum%20undercarboxylated%20osteocalcin%20is%20modulated%20by%20vitamin%20K%20epoxide%20reductase%20genotype&rft.jtitle=British%20journal%20of%20nutrition&rft.au=Nimptsch,%20Katharina&rft.date=2009-06-28&rft.volume=101&rft.issue=12&rft.spage=1812&rft.epage=1820&rft.pages=1812-1820&rft.issn=0007-1145&rft.eissn=1475-2662&rft.coden=BJNUAV&rft_id=info:doi/10.1017/S0007114508131750&rft_dat=%3Cproquest_cross%3E67414531%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213828714&rft_id=info:pmid/19025725&rft_cupid=10_1017_S0007114508131750&rfr_iscdi=true |