Toll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis

The interleukin-2-deficient (IL-2(-/-)) mouse model of ulcerative colitis was used to test the hypothesis that colonic epithelial cells (CEC) directly respond to bacterial antigens and that alterations in Toll-like receptor (TLR)-mediated signaling may occur during the development of colitis. TLR ex...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2005-03, Vol.288 (3), p.G514-G524
Hauptverfasser:	Singh, Joy Carmelina Indira, Cruickshank, Sheena Margaret, Newton, Darren James, Wakenshaw, Louise, Graham, Anne, Lan, Jinggang, Lodge, Jeremy Peter Alan, Felsburg, Peter John, Carding, Simon Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Antigens, Differentiation - physiology Bacteria - metabolism Blotting, Western Caspase 1 - metabolism Cell Separation Cells, Cultured Colitis - pathology DNA, Complementary - biosynthesis DNA, Complementary - genetics Electrophoretic Mobility Shift Assay Enzyme-Linked Immunosorbent Assay Epithelial Cells - pathology Flow Cytometry Interleukin-18 - biosynthesis Intestines - pathology Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology Mice Mice, Inbred C57BL Myeloid Differentiation Factor 88 Receptors, Cell Surface - genetics Receptors, Cell Surface - physiology Receptors, Immunologic - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - isolation & purification Signal Transduction - physiology Toll-Like Receptor 2 Toll-Like Receptor 4 Toll-Like Receptors Up-Regulation - physiology
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