Expression of oestrogen receptor and loss of E-cadherin are diagnostic for gastric metastasis of breast carcinoma
Aims : To investigate whether immunohistochemical staining for oestrogen receptor (ER)α, progesterone receptor (PgR) and E‐cadherin might be useful to differentiate between metastatic breast carcinoma and primary gastric carcinoma. Methods : Gastric biopsies of 75 patients containing adenocarcinoma...
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| Veröffentlicht in: | Histopathology 2005-02, Vol.46 (2), p.153-157 |
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| creator | Van Velthuysen, M-L F Taal, B G Van Der Hoeven, J J M Peterse, J L |
| description | Aims : To investigate whether immunohistochemical staining for oestrogen receptor (ER)α, progesterone receptor (PgR) and E‐cadherin might be useful to differentiate between metastatic breast carcinoma and primary gastric carcinoma.
Methods : Gastric biopsies of 75 patients containing adenocarcinoma were stained for ERα, PgR and E‐cadherin. Included were: Group A, 28 patients with primary gastric cancer; Group B, 28 patients with an adenocarcinoma containing gastric biopsy and a clinical diagnosis of metastatic breast carcinoma; Group C, all consecutive patients with a positive gastric biopsy in 2001 (n = 19) without clinical history of breast carcinoma and not followed by gastric resection (control group).
Results : All ERα+ or PgR+ carcinomas (n = 20) were of patients with a previous or concurrent history of breast carcinoma: 19 in group B, one in group C. In addition, absence of E‐cadherin staining was seen significantly more often in patients with metastatic breast carcinoma than in patients with primary gastric cancer (P |
| doi_str_mv | 10.1111/j.1365-2559.2005.02062.x |
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Methods : Gastric biopsies of 75 patients containing adenocarcinoma were stained for ERα, PgR and E‐cadherin. Included were: Group A, 28 patients with primary gastric cancer; Group B, 28 patients with an adenocarcinoma containing gastric biopsy and a clinical diagnosis of metastatic breast carcinoma; Group C, all consecutive patients with a positive gastric biopsy in 2001 (n = 19) without clinical history of breast carcinoma and not followed by gastric resection (control group).
Results : All ERα+ or PgR+ carcinomas (n = 20) were of patients with a previous or concurrent history of breast carcinoma: 19 in group B, one in group C. In addition, absence of E‐cadherin staining was seen significantly more often in patients with metastatic breast carcinoma than in patients with primary gastric cancer (P < 0.001).
Conclusion : Positive immunohistochemical staining for ERα or PgR of an adenocarcinoma in a gastric biopsy is diagnostic for metastatic breast carcinoma. Moreover, when carcinoma in a gastric biopsy is negative for E‐cadherin staining, metastatic breast carcinoma should be considered.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/j.1365-2559.2005.02062.x</identifier><identifier>PMID: 15693887</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>adenocarcinoma ; Adenocarcinoma - diagnosis ; Adenocarcinoma - metabolism ; Adenocarcinoma - secondary ; Biological and medical sciences ; breast ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Cadherins - analysis ; E-cadherin ; Estrogen Receptor alpha - biosynthesis ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Mammary gland diseases ; Medical sciences ; oestrogen receptor ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Receptors, Progesterone - analysis ; stomach ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - secondary ; Tumors</subject><ispartof>Histopathology, 2005-02, Vol.46 (2), p.153-157</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4352-4c91c71c2689514f2c2fa508692a6f60b55f6e7d59b456df1094dab01f1614f23</citedby><cites>FETCH-LOGICAL-c4352-4c91c71c2689514f2c2fa508692a6f60b55f6e7d59b456df1094dab01f1614f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2559.2005.02062.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2559.2005.02062.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16476553$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15693887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Velthuysen, M-L F</creatorcontrib><creatorcontrib>Taal, B G</creatorcontrib><creatorcontrib>Van Der Hoeven, J J M</creatorcontrib><creatorcontrib>Peterse, J L</creatorcontrib><title>Expression of oestrogen receptor and loss of E-cadherin are diagnostic for gastric metastasis of breast carcinoma</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims : To investigate whether immunohistochemical staining for oestrogen receptor (ER)α, progesterone receptor (PgR) and E‐cadherin might be useful to differentiate between metastatic breast carcinoma and primary gastric carcinoma.
Methods : Gastric biopsies of 75 patients containing adenocarcinoma were stained for ERα, PgR and E‐cadherin. Included were: Group A, 28 patients with primary gastric cancer; Group B, 28 patients with an adenocarcinoma containing gastric biopsy and a clinical diagnosis of metastatic breast carcinoma; Group C, all consecutive patients with a positive gastric biopsy in 2001 (n = 19) without clinical history of breast carcinoma and not followed by gastric resection (control group).
Results : All ERα+ or PgR+ carcinomas (n = 20) were of patients with a previous or concurrent history of breast carcinoma: 19 in group B, one in group C. In addition, absence of E‐cadherin staining was seen significantly more often in patients with metastatic breast carcinoma than in patients with primary gastric cancer (P < 0.001).
Conclusion : Positive immunohistochemical staining for ERα or PgR of an adenocarcinoma in a gastric biopsy is diagnostic for metastatic breast carcinoma. Moreover, when carcinoma in a gastric biopsy is negative for E‐cadherin staining, metastatic breast carcinoma should be considered.</description><subject>adenocarcinoma</subject><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - secondary</subject><subject>Biological and medical sciences</subject><subject>breast</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Cadherins - analysis</subject><subject>E-cadherin</subject><subject>Estrogen Receptor alpha - biosynthesis</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>oestrogen receptor</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Receptors, Progesterone - analysis</subject><subject>stomach</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - secondary</subject><subject>Tumors</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtv1DAURi0EokPhLyBvYJfgd5IFC1RNO5XaItHy2Fk3jj14SOKpnRHTf4_TGbVbvPG17jm274cQpqSkeX3alJQrWTApm5IRIkvCiGLl_gVaPDVeogXhpCkIVdUJepPShhBaccZeoxMqVcPrulqg--V-G21KPow4OBxsmmJY2xFHa-x2ChHD2OE-pDS3l4WB7reNfsQQLe48rMeQJm-wy-QaspzrwU65guQfnTbafMIGovFjGOAteuWgT_bdcT9F38-Xd2er4urrxeXZl6vCCC5ZIUxDTUUNU3UjqXDMMAeS1KphoJwirZRO2aqTTSuk6hwljeigJdRRNeP8FH083LuN4X6X59KDT8b2PYw27JJWlaCCKpXB-gCamMeM1ult9APEB02JnuPWGz2nqudU9Ry3foxb77P6_vjGrh1s9ywe883AhyMAyUDvIozGp2dOiUpJyTP3-cD99b19-O8P6NXl7Vxlvzj4Pk12_-RD_JPn5JXUP28u9K26W327_iX0D_4P4merRg</recordid><startdate>200502</startdate><enddate>200502</enddate><creator>Van Velthuysen, M-L F</creator><creator>Taal, B G</creator><creator>Van Der Hoeven, J J M</creator><creator>Peterse, J L</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200502</creationdate><title>Expression of oestrogen receptor and loss of E-cadherin are diagnostic for gastric metastasis of breast carcinoma</title><author>Van Velthuysen, M-L F ; Taal, B G ; Van Der Hoeven, J J M ; Peterse, J L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4352-4c91c71c2689514f2c2fa508692a6f60b55f6e7d59b456df1094dab01f1614f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>adenocarcinoma</topic><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - secondary</topic><topic>Biological and medical sciences</topic><topic>breast</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Cadherins - analysis</topic><topic>E-cadherin</topic><topic>Estrogen Receptor alpha - biosynthesis</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>oestrogen receptor</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Receptors, Progesterone - analysis</topic><topic>stomach</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - secondary</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Velthuysen, M-L F</creatorcontrib><creatorcontrib>Taal, B G</creatorcontrib><creatorcontrib>Van Der Hoeven, J J M</creatorcontrib><creatorcontrib>Peterse, J L</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Velthuysen, M-L F</au><au>Taal, B G</au><au>Van Der Hoeven, J J M</au><au>Peterse, J L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of oestrogen receptor and loss of E-cadherin are diagnostic for gastric metastasis of breast carcinoma</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2005-02</date><risdate>2005</risdate><volume>46</volume><issue>2</issue><spage>153</spage><epage>157</epage><pages>153-157</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Aims : To investigate whether immunohistochemical staining for oestrogen receptor (ER)α, progesterone receptor (PgR) and E‐cadherin might be useful to differentiate between metastatic breast carcinoma and primary gastric carcinoma.
Methods : Gastric biopsies of 75 patients containing adenocarcinoma were stained for ERα, PgR and E‐cadherin. Included were: Group A, 28 patients with primary gastric cancer; Group B, 28 patients with an adenocarcinoma containing gastric biopsy and a clinical diagnosis of metastatic breast carcinoma; Group C, all consecutive patients with a positive gastric biopsy in 2001 (n = 19) without clinical history of breast carcinoma and not followed by gastric resection (control group).
Results : All ERα+ or PgR+ carcinomas (n = 20) were of patients with a previous or concurrent history of breast carcinoma: 19 in group B, one in group C. In addition, absence of E‐cadherin staining was seen significantly more often in patients with metastatic breast carcinoma than in patients with primary gastric cancer (P < 0.001).
Conclusion : Positive immunohistochemical staining for ERα or PgR of an adenocarcinoma in a gastric biopsy is diagnostic for metastatic breast carcinoma. Moreover, when carcinoma in a gastric biopsy is negative for E‐cadherin staining, metastatic breast carcinoma should be considered.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15693887</pmid><doi>10.1111/j.1365-2559.2005.02062.x</doi><tpages>5</tpages></addata></record> |
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| subjects | adenocarcinoma Adenocarcinoma - diagnosis Adenocarcinoma - metabolism Adenocarcinoma - secondary Biological and medical sciences breast Breast Neoplasms - metabolism Breast Neoplasms - pathology Cadherins - analysis E-cadherin Estrogen Receptor alpha - biosynthesis Female Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Mammary gland diseases Medical sciences oestrogen receptor Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptors, Progesterone - analysis stomach Stomach Neoplasms - diagnosis Stomach Neoplasms - metabolism Stomach Neoplasms - secondary Tumors |
| title | Expression of oestrogen receptor and loss of E-cadherin are diagnostic for gastric metastasis of breast carcinoma |
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