Epigenetic status and aberrant expression of the maspin gene in human hepato-biliary tract carcinomas

We examined expression of maspin and the epigenetic status of its gene in 40 primary hepato-biliary tract carcinomas and 11 cell lines originating from hepato-pancreatico-biliary tract carcinomas. Aberrant maspin expression was frequently observed immunohistochemically in biliary tract carcinomas (2...

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Veröffentlicht in:	Laboratory investigation 2005-02, Vol.85 (2), p.214-224
Hauptverfasser:	Fujisawa, Kentaro, Maesawa, Chihaya, Sato, Ryo, Wada, Kei, Ogasawara, Satoshi, Akiyama, Yuji, Takeda, Masaru, Fujita, Tomohiro, Otsuka, Koki, Higuchi, Taro, Suzuki, Kazuyuki, Saito, Kazuyoshi, Masuda, Tomoyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Bile Duct Neoplasms - genetics Bile Duct Neoplasms - metabolism Biological and medical sciences Biotechnology Carcinoma - genetics Carcinoma - metabolism Cell Line, Tumor Chromatin - metabolism DNA Methylation Epigenesis, Genetic Female Fundamental and applied biological sciences. Psychology Genes, Tumor Suppressor hepato-biliary tract carcinoma histone acetylation Humans Hydroxamic Acids - pharmacology Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Liver Neoplasms - genetics Liver Neoplasms - metabolism Male maspin Medical sciences Medicine Medicine & Public Health Middle Aged Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pathology Precipitin Tests Promoter Regions, Genetic Protein Synthesis Inhibitors - pharmacology Proteins - genetics Proteins - metabolism research-article RNA, Messenger - metabolism Sequence Analysis, DNA Serpins - genetics Serpins - metabolism tumor suppressor gene
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