Intracellular Localization and Trafficking of Fluorescein-Labeled Cisplatin in Human Ovarian Carcinoma Cells

Purpose: We sought to identify the subcellular compartments in which cisplatin [ cis -diamminedichloroplatinum (DDP)] accumulates in human ovarian carcinoma cells and define its export pathways. Experimental Design: Deconvoluting digital microscopy was used to identify the subcellular location of fl...

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Veröffentlicht in:	Clinical cancer research 2005-01, Vol.11 (2), p.756-767
Hauptverfasser:	SAFAEI, Roohangiz, KATANO, Kuniyuki, LARSON, Barrett J, SAMIMI, Goli, HOLZER, Alison K, NAERDEMANN, Wiltrud, TOMIOKA, Mika, GOODMAN, Murray, HOWELL, Stephen B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Androstadienes - pharmacology Antineoplastic agents Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Biological and medical sciences Biological Transport Brefeldin A - pharmacology Cation Transport Proteins - metabolism Cell Nucleus - metabolism cisplatin Cisplatin - metabolism Cisplatin - pharmacology Contrast Media Copper - chemistry Copper - metabolism Copper-transporting ATPases Cytoplasm - metabolism drug resistance endosome Female Female genital diseases Fluorescein Golgi Golgi Apparatus - metabolism Golgi network Gynecology. Andrology. Obstetrics Humans Isoquinolines - pharmacology lysosome Lysosomes - metabolism Medical sciences Microscopy, Confocal Microscopy, Fluorescence Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Pharmacology. Drug treatments Protein Kinase Inhibitors - pharmacology Protein Synthesis Inhibitors - pharmacology Recombinant Fusion Proteins - metabolism Subcellular Fractions Sulfonamides - pharmacology trans Tumor Cells, Cultured Tumors vesicular trafficking Wortmannin
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