Hyperhomocysteinaemia in chronic liver diseases: role of disease stage, vitamin status and methylenetetrahydrofolate reductase genetics
: Background/Aims: The liver plays a key role in sulphur aminoacid metabolism hence, homocysteine metabolism may be impaired in chronic liver diseases. The aim of this study was to investigate, in patients affected by chronic liver diseases, (1) the prevalence of hyperhomocysteinaemia and (2) the ro...
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| Veröffentlicht in: | Liver international 2005-02, Vol.25 (1), p.49-56 |
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| creator | Ventura, Paolo Rosa, Maria Cristina Abbati, Gianluca Marchini, Stefano Grandone, Elvira Vergura, Patrizia Tremosini, Silvia Zeneroli, Maria Luisa |
| description | : Background/Aims: The liver plays a key role in sulphur aminoacid metabolism hence, homocysteine metabolism may be impaired in chronic liver diseases. The aim of this study was to investigate, in patients affected by chronic liver diseases, (1) the prevalence of hyperhomocysteinaemia and (2) the role of its determinants such as the stage and the aetiology of disease, vitamin status, genetic documented alterations (methylenetetrahydrofolate reductase deficiency) and presence/absence of documented malignant evolution (hepatocellular carcinoma).
Material and Methods: One hundred and thirty patients with chronic liver disease (34 with chronic active hepatitis, 12 with fatty liver and 88 with liver cirrhosis) and 50 healthy age‐matched control subjects were included into the study.
Results: Hyperhomocysteinaemia was defined as homocysteine plasma levels greater than 12.6 μmol/l. Hyperhomocysteinaemia prevalence in liver cirrhosis group was 40.9%, significantly higher (all P |
| doi_str_mv | 10.1111/j.1478-3231.2005.01042.x |
| format | Article |
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Material and Methods: One hundred and thirty patients with chronic liver disease (34 with chronic active hepatitis, 12 with fatty liver and 88 with liver cirrhosis) and 50 healthy age‐matched control subjects were included into the study.
Results: Hyperhomocysteinaemia was defined as homocysteine plasma levels greater than 12.6 μmol/l. Hyperhomocysteinaemia prevalence in liver cirrhosis group was 40.9%, significantly higher (all P<0.01) with respect to controls (12%), chronic active hepatitis (14.7%) and fatty liver (25%) groups and increased with Child–Pugh stage [Child A: 22.2%, Child B (50%); Child C (58.3%)]. In chronic‐active hepatitis and liver cirrhosis, the prevalence of subjects with methylenetetrahydrofolate reductase C677→T mutation (both as CT and as TT) and hyperhomocysteinaemia results in significantly higher levels with respect to controls. Methylenetetrahydrofolate reductase C677→T mutation and disease stage showed to be the most important predictive factors of hyperhomocysteinaemia in liver cirrhosis whereas the influence of homocysteine‐related vitamin status seems to have a secondary role.
Conclusions: In conclusion hyperhomocysteinaemia is highly prevalent in liver cirrhosis but not in other chronic liver diseases; it may contribute to fibrogenesis and vascular complication of liver cirrhosis.</description><identifier>ISSN: 1478-3223</identifier><identifier>EISSN: 1478-3231</identifier><identifier>DOI: 10.1111/j.1478-3231.2005.01042.x</identifier><identifier>PMID: 15698398</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Avitaminosis ; Carcinoma, Hepatocellular - complications ; Carcinoma, Hepatocellular - enzymology ; Carcinoma, Hepatocellular - pathology ; chronic active hepatitis ; Chronic Disease ; fatty liver ; Fatty Liver - complications ; Fatty Liver - enzymology ; Fatty Liver - pathology ; Genetic Predisposition to Disease ; Hepatitis, Chronic - complications ; Hepatitis, Chronic - enzymology ; Hepatitis, Chronic - pathology ; Humans ; hyperhomocysteinaemia ; Hyperhomocysteinemia - complications ; Hyperhomocysteinemia - enzymology ; Hyperhomocysteinemia - pathology ; liver cirrhosis ; Liver Cirrhosis - complications ; Liver Cirrhosis - enzymology ; Liver Cirrhosis - pathology ; Liver Diseases - complications ; Liver Diseases - enzymology ; Liver Diseases - pathology ; Liver Neoplasms - complications ; Liver Neoplasms - enzymology ; Liver Neoplasms - pathology ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; MTHFR ; Mutation, Missense ; Point Mutation</subject><ispartof>Liver international, 2005-02, Vol.25 (1), p.49-56</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4052-5bedb2e8f405f75c79dbff2c0a59e97bf606609aff4e9a9bd8ff492825f498823</citedby><cites>FETCH-LOGICAL-c4052-5bedb2e8f405f75c79dbff2c0a59e97bf606609aff4e9a9bd8ff492825f498823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1478-3231.2005.01042.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1478-3231.2005.01042.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15698398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ventura, Paolo</creatorcontrib><creatorcontrib>Rosa, Maria Cristina</creatorcontrib><creatorcontrib>Abbati, Gianluca</creatorcontrib><creatorcontrib>Marchini, Stefano</creatorcontrib><creatorcontrib>Grandone, Elvira</creatorcontrib><creatorcontrib>Vergura, Patrizia</creatorcontrib><creatorcontrib>Tremosini, Silvia</creatorcontrib><creatorcontrib>Zeneroli, Maria Luisa</creatorcontrib><title>Hyperhomocysteinaemia in chronic liver diseases: role of disease stage, vitamin status and methylenetetrahydrofolate reductase genetics</title><title>Liver international</title><addtitle>Liver Int</addtitle><description>: Background/Aims: The liver plays a key role in sulphur aminoacid metabolism hence, homocysteine metabolism may be impaired in chronic liver diseases. The aim of this study was to investigate, in patients affected by chronic liver diseases, (1) the prevalence of hyperhomocysteinaemia and (2) the role of its determinants such as the stage and the aetiology of disease, vitamin status, genetic documented alterations (methylenetetrahydrofolate reductase deficiency) and presence/absence of documented malignant evolution (hepatocellular carcinoma).
Material and Methods: One hundred and thirty patients with chronic liver disease (34 with chronic active hepatitis, 12 with fatty liver and 88 with liver cirrhosis) and 50 healthy age‐matched control subjects were included into the study.
Results: Hyperhomocysteinaemia was defined as homocysteine plasma levels greater than 12.6 μmol/l. Hyperhomocysteinaemia prevalence in liver cirrhosis group was 40.9%, significantly higher (all P<0.01) with respect to controls (12%), chronic active hepatitis (14.7%) and fatty liver (25%) groups and increased with Child–Pugh stage [Child A: 22.2%, Child B (50%); Child C (58.3%)]. In chronic‐active hepatitis and liver cirrhosis, the prevalence of subjects with methylenetetrahydrofolate reductase C677→T mutation (both as CT and as TT) and hyperhomocysteinaemia results in significantly higher levels with respect to controls. Methylenetetrahydrofolate reductase C677→T mutation and disease stage showed to be the most important predictive factors of hyperhomocysteinaemia in liver cirrhosis whereas the influence of homocysteine‐related vitamin status seems to have a secondary role.
Conclusions: In conclusion hyperhomocysteinaemia is highly prevalent in liver cirrhosis but not in other chronic liver diseases; it may contribute to fibrogenesis and vascular complication of liver cirrhosis.</description><subject>Avitaminosis</subject><subject>Carcinoma, Hepatocellular - complications</subject><subject>Carcinoma, Hepatocellular - enzymology</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>chronic active hepatitis</subject><subject>Chronic Disease</subject><subject>fatty liver</subject><subject>Fatty Liver - complications</subject><subject>Fatty Liver - enzymology</subject><subject>Fatty Liver - pathology</subject><subject>Genetic Predisposition to Disease</subject><subject>Hepatitis, Chronic - complications</subject><subject>Hepatitis, Chronic - enzymology</subject><subject>Hepatitis, Chronic - pathology</subject><subject>Humans</subject><subject>hyperhomocysteinaemia</subject><subject>Hyperhomocysteinemia - complications</subject><subject>Hyperhomocysteinemia - enzymology</subject><subject>Hyperhomocysteinemia - pathology</subject><subject>liver cirrhosis</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - enzymology</subject><subject>Liver Cirrhosis - pathology</subject><subject>Liver Diseases - complications</subject><subject>Liver Diseases - enzymology</subject><subject>Liver Diseases - pathology</subject><subject>Liver Neoplasms - complications</subject><subject>Liver Neoplasms - enzymology</subject><subject>Liver Neoplasms - pathology</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>MTHFR</subject><subject>Mutation, Missense</subject><subject>Point Mutation</subject><issn>1478-3223</issn><issn>1478-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u1DAQxiMEon_gFZBPnEhqO3ESI3FAFdstWgFCQI-W44y7XpJ4sZ128wR97Trssr3iy8x4vt_Ymi9JEMEZiedik5GiqtOc5iSjGLMME1zQbPcsOT02nh9zmp8kZ95vMCacM_IyOSGs5HXO69PkYTltwa1tb9XkA5hBQm8kMgNSa2cHo1Bn7sCh1niQHvx75GwHyOp_N8gHeQvv0J0Jso9YLMPokRxa1ENYTx0MECA4uZ5aZ7XtZADkoB1VmOnbuW2Uf5W80LLz8PoQz5Ofi08_Lpfp6uvV9eXHVaoKzGjKGmgbCrWOla6YqnjbaE0VlowDrxpd4rLEXGpdAJe8aeuYcVpTFkNd0_w8ebufu3X2zwg-iN54BV0nB7CjF2VVEMqLIgrrvVA5670DLbbO9NJNgmAxmyA2Yt6vmHctZhPEXxPELqJvDm-MTQ_tE3jYehR82AvuTQfTfw8Wq-tfcxb5dM-baNnuyEv3O_4_r5i4-XIlbr59XiwJ-y4W-SMA8qlC</recordid><startdate>200502</startdate><enddate>200502</enddate><creator>Ventura, Paolo</creator><creator>Rosa, Maria Cristina</creator><creator>Abbati, Gianluca</creator><creator>Marchini, Stefano</creator><creator>Grandone, Elvira</creator><creator>Vergura, Patrizia</creator><creator>Tremosini, Silvia</creator><creator>Zeneroli, Maria Luisa</creator><general>Munksgaard International Publishers</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200502</creationdate><title>Hyperhomocysteinaemia in chronic liver diseases: role of disease stage, vitamin status and methylenetetrahydrofolate reductase genetics</title><author>Ventura, Paolo ; Rosa, Maria Cristina ; Abbati, Gianluca ; Marchini, Stefano ; Grandone, Elvira ; Vergura, Patrizia ; Tremosini, Silvia ; Zeneroli, Maria Luisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4052-5bedb2e8f405f75c79dbff2c0a59e97bf606609aff4e9a9bd8ff492825f498823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Avitaminosis</topic><topic>Carcinoma, Hepatocellular - complications</topic><topic>Carcinoma, Hepatocellular - enzymology</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>chronic active hepatitis</topic><topic>Chronic Disease</topic><topic>fatty liver</topic><topic>Fatty Liver - complications</topic><topic>Fatty Liver - enzymology</topic><topic>Fatty Liver - pathology</topic><topic>Genetic Predisposition to Disease</topic><topic>Hepatitis, Chronic - complications</topic><topic>Hepatitis, Chronic - enzymology</topic><topic>Hepatitis, Chronic - pathology</topic><topic>Humans</topic><topic>hyperhomocysteinaemia</topic><topic>Hyperhomocysteinemia - complications</topic><topic>Hyperhomocysteinemia - enzymology</topic><topic>Hyperhomocysteinemia - pathology</topic><topic>liver cirrhosis</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Cirrhosis - enzymology</topic><topic>Liver Cirrhosis - pathology</topic><topic>Liver Diseases - complications</topic><topic>Liver Diseases - enzymology</topic><topic>Liver Diseases - pathology</topic><topic>Liver Neoplasms - complications</topic><topic>Liver Neoplasms - enzymology</topic><topic>Liver Neoplasms - pathology</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>MTHFR</topic><topic>Mutation, Missense</topic><topic>Point Mutation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ventura, Paolo</creatorcontrib><creatorcontrib>Rosa, Maria Cristina</creatorcontrib><creatorcontrib>Abbati, Gianluca</creatorcontrib><creatorcontrib>Marchini, Stefano</creatorcontrib><creatorcontrib>Grandone, Elvira</creatorcontrib><creatorcontrib>Vergura, Patrizia</creatorcontrib><creatorcontrib>Tremosini, Silvia</creatorcontrib><creatorcontrib>Zeneroli, Maria Luisa</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Liver international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ventura, Paolo</au><au>Rosa, Maria Cristina</au><au>Abbati, Gianluca</au><au>Marchini, Stefano</au><au>Grandone, Elvira</au><au>Vergura, Patrizia</au><au>Tremosini, Silvia</au><au>Zeneroli, Maria Luisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperhomocysteinaemia in chronic liver diseases: role of disease stage, vitamin status and methylenetetrahydrofolate reductase genetics</atitle><jtitle>Liver international</jtitle><addtitle>Liver Int</addtitle><date>2005-02</date><risdate>2005</risdate><volume>25</volume><issue>1</issue><spage>49</spage><epage>56</epage><pages>49-56</pages><issn>1478-3223</issn><eissn>1478-3231</eissn><abstract>: Background/Aims: The liver plays a key role in sulphur aminoacid metabolism hence, homocysteine metabolism may be impaired in chronic liver diseases. The aim of this study was to investigate, in patients affected by chronic liver diseases, (1) the prevalence of hyperhomocysteinaemia and (2) the role of its determinants such as the stage and the aetiology of disease, vitamin status, genetic documented alterations (methylenetetrahydrofolate reductase deficiency) and presence/absence of documented malignant evolution (hepatocellular carcinoma).
Material and Methods: One hundred and thirty patients with chronic liver disease (34 with chronic active hepatitis, 12 with fatty liver and 88 with liver cirrhosis) and 50 healthy age‐matched control subjects were included into the study.
Results: Hyperhomocysteinaemia was defined as homocysteine plasma levels greater than 12.6 μmol/l. Hyperhomocysteinaemia prevalence in liver cirrhosis group was 40.9%, significantly higher (all P<0.01) with respect to controls (12%), chronic active hepatitis (14.7%) and fatty liver (25%) groups and increased with Child–Pugh stage [Child A: 22.2%, Child B (50%); Child C (58.3%)]. In chronic‐active hepatitis and liver cirrhosis, the prevalence of subjects with methylenetetrahydrofolate reductase C677→T mutation (both as CT and as TT) and hyperhomocysteinaemia results in significantly higher levels with respect to controls. Methylenetetrahydrofolate reductase C677→T mutation and disease stage showed to be the most important predictive factors of hyperhomocysteinaemia in liver cirrhosis whereas the influence of homocysteine‐related vitamin status seems to have a secondary role.
Conclusions: In conclusion hyperhomocysteinaemia is highly prevalent in liver cirrhosis but not in other chronic liver diseases; it may contribute to fibrogenesis and vascular complication of liver cirrhosis.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>15698398</pmid><doi>10.1111/j.1478-3231.2005.01042.x</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Avitaminosis Carcinoma, Hepatocellular - complications Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - pathology chronic active hepatitis Chronic Disease fatty liver Fatty Liver - complications Fatty Liver - enzymology Fatty Liver - pathology Genetic Predisposition to Disease Hepatitis, Chronic - complications Hepatitis, Chronic - enzymology Hepatitis, Chronic - pathology Humans hyperhomocysteinaemia Hyperhomocysteinemia - complications Hyperhomocysteinemia - enzymology Hyperhomocysteinemia - pathology liver cirrhosis Liver Cirrhosis - complications Liver Cirrhosis - enzymology Liver Cirrhosis - pathology Liver Diseases - complications Liver Diseases - enzymology Liver Diseases - pathology Liver Neoplasms - complications Liver Neoplasms - enzymology Liver Neoplasms - pathology Methylenetetrahydrofolate Reductase (NADPH2) - genetics MTHFR Mutation, Missense Point Mutation |
| title | Hyperhomocysteinaemia in chronic liver diseases: role of disease stage, vitamin status and methylenetetrahydrofolate reductase genetics |
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