One Year of Transgenic Overexpression of Osteoprotegerin in Rats Suppressed Bone Resorption and Increased Vertebral Bone Volume, Density, and Strength

RANKL is an essential mediator of bone resorption, and its activity is inhibited by osteoprotegerin (OPG). Transgenic (Tg) rats were engineered to continuously overexpress OPG to study the effects of continuous long‐term RANKL inhibition on bone volume, density, and strength. Lumbar vertebrae, femur...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of bone and mineral research 2009-07, Vol.24 (7), p.1234-1246
Hauptverfasser:	Ominsky, Michael S, Stolina, Marina, Li, Xiaodong, Corbin, Timothy J, Asuncion, Franklin J, Barrero, Mauricio, Niu, Qing‐Tian, Dwyer, Denise, Adamu, Steven, Warmington, Kelly S, Grisanti, Mario, Tan, Hong L, Ke, Hua Z, Simonet, William S, Kostenuik, Paul J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone Density bone quality Bone Remodeling bone resorption bone strength Female Fundamental and applied biological sciences. Psychology Gene Expression Lumbar Vertebrae - growth & development Lumbar Vertebrae - metabolism Organ Size Osteoclasts - metabolism Osteopetrosis - metabolism osteoprotegerin Osteoprotegerin - biosynthesis Osteoprotegerin - genetics RANKL Rats Rats, Sprague-Dawley Rats, Transgenic Skeleton and joints Time Factors Vertebrates: osteoarticular system, musculoskeletal system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!