[N-methyl-3H3]AZ10419369 Binding to the 5-HT1B Receptor: In Vitro Characterization and in Vivo Receptor Occupancy

Radiotracers suitable for positron emission tomography studies often serve as preclinical tools for in vivo receptor occupancy. The serotonin 1B receptor (5-HT 1B ) subtype is a pharmacological target used to discover treatments for various psychiatric and neurological disorders. In psychiatry, 5-HT...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2009-07, Vol.330 (1), p.342-351
Hauptverfasser:	Maier, Donna L, Sobotka-Briner, Cindy, Ding, Min, Powell, Mark E, Jiang, Qiaoling, Hill, Geraldine, Heys, J Richard, Elmore, Charles S, Pierson, M Edward, Mrzljak, Ladislav
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzopyrans - chemical synthesis Benzopyrans - metabolism Benzopyrans - pharmacology Cell Line CHO Cells Cricetinae Cricetulus Guinea Pigs Haplorhini Humans Male Morpholines - chemical synthesis Morpholines - metabolism Morpholines - pharmacology Piperazines - chemical synthesis Piperazines - metabolism Piperazines - pharmacology Protein Binding - drug effects Protein Binding - physiology Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - metabolism Radiopharmaceuticals - pharmacology Receptor, Serotonin, 5-HT1B - metabolism Serotonin 5-HT1 Receptor Antagonists Serotonin Antagonists - chemical synthesis Serotonin Antagonists - metabolism Serotonin Antagonists - pharmacology Tritium - metabolism
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