What Are Next Generation Innovative Therapeutic Targets? Clues from Genetic, Structural, Physicochemical, and Systems Profiles of Successful Targets

Low target discovery rate has been linked to inadequate consideration of multiple factors that collectively contribute to druggability. These factors include sequence, structural, physicochemical, and systems profiles. Methods individually exploring each of these profiles for target identification h...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2009-07, Vol.330 (1), p.304-315
Hauptverfasser:	Zhu, Feng, Han, LianYi, Zheng, ChanJuan, Xie, Bin, Tammi, Martti T., Yang, ShengYong, Wei, YuQuan, Chen, YuZong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemical Phenomena - drug effects Clinical Trials as Topic - methods Clinical Trials as Topic - trends Drug Delivery Systems - methods Drug Delivery Systems - trends Drug Design Drug Discovery - methods Drug Discovery - trends Gene Targeting - methods Gene Targeting - trends Humans Structure-Activity Relationship
Online-Zugang:	Volltext
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