Ribozyme targeting of the growth factor pleiotrophin in established tumors: a gene therapy approach

The growth and metastasis of solid tumors relies on the activities of polypeptide growth factors to recruit stromal tissue and expand the tumor mass. Pleiotrophin (PTN) is a secreted growth factor with angiogenic activity that has been found to contribute to the growth and metastasis of tumors inclu...

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Veröffentlicht in:	Gene therapy 2005-02, Vol.12 (4), p.339-346
Hauptverfasser:	Malerczyk, C, Schulte, A M, Czubayko, F, Bellon, L, Macejak, D, Riegel, A T, Wellstein, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Angiogenesis Animals Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Cancer Care and treatment Carrier Proteins - genetics Catalytic RNA Cell Biology Cytokines - genetics Expression vectors Fundamental and applied biological sciences. Psychology Gene Expression Gene Expression - drug effects Gene Therapy Genetic aspects Genetic Therapy - methods Genetic Vectors - genetics Growth factors Health aspects Health. Pharmaceutical industry Human Genetics Humans Industrial applications and implications. Economical aspects Medical sciences Melanoma Melanoma - blood supply Melanoma - therapy Metastases Metastasis Mice Mice, Nude mRNA Nanotechnology Neovascularization, Pathologic - prevention & control Physiological aspects Pleiotrophin research-article Ribozymes RNA, Catalytic RNA, Messenger - genetics Serum levels Skin Neoplasms - blood supply Skin Neoplasms - therapy Solid tumors Tetracycline - therapeutic use Transfection - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tumors Xenografts
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