Is premature adrenarche a risk factor for atherogenesis?
Background : The aim of this study was to evaluate serum lipids and atherosclerosis risk in children with premature adrenarche (PA) in comparison with age‐matched controls. Methods : Lipid profile, glucose, insulin, and insulin‐like growth factor binding protein‐1 (IGFBP‐1) levels were studied in 24...
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| Veröffentlicht in: | Pediatrics international 2005-02, Vol.47 (1), p.20-25 |
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| creator | Güven, Ayla Cinaz, Peyami Bideci, Aysun |
| description | Background
: The aim of this study was to evaluate serum lipids and atherosclerosis risk in children with premature adrenarche (PA) in comparison with age‐matched controls.
Methods
: Lipid profile, glucose, insulin, and insulin‐like growth factor binding protein‐1 (IGFBP‐1) levels were studied in 24 girls with premature adrenarche and 13 healthy age‐matched controls after overnight fasting.
Results
: The bone age, weight and body mass index were higher in the premature adrenarche group than the control group. Systolic, diastolic and mean arterial blood pressure of patients were higher than controls. The mean total cholesterol (TC), low‐density lipoprotein‐cholesterol (LDL‐C), very low‐density lipoprotein‐cholesterol (VLDL‐C), TC/high‐density lipoprotein‐cholesterol (HDL‐C) and LDL‐C/HDL‐C ratio, and atherogenic index were significantly higher in the premature adrenarche group compared to the control group. There was no significant difference in the levels of apolipoprotein A1, apolipoprotein B and lipoprotein (a) in both groups. In the premature adrenarche group there were inverse correlations between the levels of IGFBP‐1 and TC/HDL‐C (rho, –0.54; P, 0.011), and LDL‐C/HDL‐C (rho, –0.50; P |
| doi_str_mv | 10.1111/j.1442-200x.2004.02006.x |
| format | Article |
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: The aim of this study was to evaluate serum lipids and atherosclerosis risk in children with premature adrenarche (PA) in comparison with age‐matched controls.
Methods
: Lipid profile, glucose, insulin, and insulin‐like growth factor binding protein‐1 (IGFBP‐1) levels were studied in 24 girls with premature adrenarche and 13 healthy age‐matched controls after overnight fasting.
Results
: The bone age, weight and body mass index were higher in the premature adrenarche group than the control group. Systolic, diastolic and mean arterial blood pressure of patients were higher than controls. The mean total cholesterol (TC), low‐density lipoprotein‐cholesterol (LDL‐C), very low‐density lipoprotein‐cholesterol (VLDL‐C), TC/high‐density lipoprotein‐cholesterol (HDL‐C) and LDL‐C/HDL‐C ratio, and atherogenic index were significantly higher in the premature adrenarche group compared to the control group. There was no significant difference in the levels of apolipoprotein A1, apolipoprotein B and lipoprotein (a) in both groups. In the premature adrenarche group there were inverse correlations between the levels of IGFBP‐1 and TC/HDL‐C (rho, –0.54; P, 0.011), and LDL‐C/HDL‐C (rho, –0.50; P < 0.05) and atherogenic index (AI; rho, –0.54; P < 0.05). dehydroepiandrosterone sulfate levels of the patients was negatively correlated with AI and TC/HDL‐C (rho, –0.0503, P < 0.05).
Conclusions
: Girls with premature adrenarche should be investigated for serum lipids, and atherogenic risk criteria should be assessed periodically in the follow up of patients with PA, as PA seems to be a risk factor for future atherosclerosis.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/j.1442-200x.2004.02006.x</identifier><identifier>PMID: 15693861</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Pty</publisher><subject>Adrenal Glands - secretion ; Arteriosclerosis - epidemiology ; atherogenic index ; Body Size ; Cardiovascular disease ; Case-Control Studies ; Child ; Cholesterol ; Comparative studies ; Female ; Girls ; high-density lipoprotein-cholesterol ; Humans ; insulin-like growth factor binding protein-1 ; Lipids - blood ; low-density lipoprotein-cholesterol ; Pediatrics ; premature adrenarche ; Puberty, Precocious - complications ; Risk Factors ; total cholesterol</subject><ispartof>Pediatrics international, 2005-02, Vol.47 (1), p.20-25</ispartof><rights>Copyright Blackwell Publishing Feb 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4856-38e374c1571a32f4d5339c831a3cb88f75f96cf8f51fffc35f56af6fd4e2872d3</citedby><cites>FETCH-LOGICAL-c4856-38e374c1571a32f4d5339c831a3cb88f75f96cf8f51fffc35f56af6fd4e2872d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1442-200x.2004.02006.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1442-200x.2004.02006.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15693861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Güven, Ayla</creatorcontrib><creatorcontrib>Cinaz, Peyami</creatorcontrib><creatorcontrib>Bideci, Aysun</creatorcontrib><title>Is premature adrenarche a risk factor for atherogenesis?</title><title>Pediatrics international</title><addtitle>Pediatr Int</addtitle><description>Background
: The aim of this study was to evaluate serum lipids and atherosclerosis risk in children with premature adrenarche (PA) in comparison with age‐matched controls.
Methods
: Lipid profile, glucose, insulin, and insulin‐like growth factor binding protein‐1 (IGFBP‐1) levels were studied in 24 girls with premature adrenarche and 13 healthy age‐matched controls after overnight fasting.
Results
: The bone age, weight and body mass index were higher in the premature adrenarche group than the control group. Systolic, diastolic and mean arterial blood pressure of patients were higher than controls. The mean total cholesterol (TC), low‐density lipoprotein‐cholesterol (LDL‐C), very low‐density lipoprotein‐cholesterol (VLDL‐C), TC/high‐density lipoprotein‐cholesterol (HDL‐C) and LDL‐C/HDL‐C ratio, and atherogenic index were significantly higher in the premature adrenarche group compared to the control group. There was no significant difference in the levels of apolipoprotein A1, apolipoprotein B and lipoprotein (a) in both groups. In the premature adrenarche group there were inverse correlations between the levels of IGFBP‐1 and TC/HDL‐C (rho, –0.54; P, 0.011), and LDL‐C/HDL‐C (rho, –0.50; P < 0.05) and atherogenic index (AI; rho, –0.54; P < 0.05). dehydroepiandrosterone sulfate levels of the patients was negatively correlated with AI and TC/HDL‐C (rho, –0.0503, P < 0.05).
Conclusions
: Girls with premature adrenarche should be investigated for serum lipids, and atherogenic risk criteria should be assessed periodically in the follow up of patients with PA, as PA seems to be a risk factor for future atherosclerosis.</description><subject>Adrenal Glands - secretion</subject><subject>Arteriosclerosis - epidemiology</subject><subject>atherogenic index</subject><subject>Body Size</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Cholesterol</subject><subject>Comparative studies</subject><subject>Female</subject><subject>Girls</subject><subject>high-density lipoprotein-cholesterol</subject><subject>Humans</subject><subject>insulin-like growth factor binding protein-1</subject><subject>Lipids - blood</subject><subject>low-density lipoprotein-cholesterol</subject><subject>Pediatrics</subject><subject>premature adrenarche</subject><subject>Puberty, Precocious - complications</subject><subject>Risk Factors</subject><subject>total cholesterol</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUN1LwzAcDKL4Mf0XpPjgW2u-kz2IyNRtMFRQmW8hpom2butMWpz_vamdCj4ZyP0u5O5IDoAEwQzFdVJmiFKcYghXWQSawYg8W22A3e-Lx83ICZaphFzsgL0QSgihFJJugx3EeJ9IjnaBHIdk6e1c1423ic69XWhvXiJNfBFeE6dNXfnExa3rF-urZ7uwoQhn-2DL6VmwB-vZAw9Xl_eDUTq5GY4H55PUUMl4SqQlghrEBNIEO5ozQvpGkngyT1I6wVyfGycdQ845Q5hjXDvucmqxFDgnPXDc5S599dbYUKt5EYydzfTCVk1QXFAEMaFRePRHWFaNX8S3KYwwwxwLGEWyExlfheCtU0tfzLX_UAiqtlpVqrZB1VbbAlVf1apVtB6u85unuc1_jesuo-C0E7wXM_vx72B1e3nRsuhPO38Rarv68Wv_Gj9JBFPT66GaUkQndHSnpuQTd5GVlw</recordid><startdate>200502</startdate><enddate>200502</enddate><creator>Güven, Ayla</creator><creator>Cinaz, Peyami</creator><creator>Bideci, Aysun</creator><general>Blackwell Science Pty</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200502</creationdate><title>Is premature adrenarche a risk factor for atherogenesis?</title><author>Güven, Ayla ; Cinaz, Peyami ; Bideci, Aysun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4856-38e374c1571a32f4d5339c831a3cb88f75f96cf8f51fffc35f56af6fd4e2872d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adrenal Glands - secretion</topic><topic>Arteriosclerosis - epidemiology</topic><topic>atherogenic index</topic><topic>Body Size</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Cholesterol</topic><topic>Comparative studies</topic><topic>Female</topic><topic>Girls</topic><topic>high-density lipoprotein-cholesterol</topic><topic>Humans</topic><topic>insulin-like growth factor binding protein-1</topic><topic>Lipids - blood</topic><topic>low-density lipoprotein-cholesterol</topic><topic>Pediatrics</topic><topic>premature adrenarche</topic><topic>Puberty, Precocious - complications</topic><topic>Risk Factors</topic><topic>total cholesterol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Güven, Ayla</creatorcontrib><creatorcontrib>Cinaz, Peyami</creatorcontrib><creatorcontrib>Bideci, Aysun</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Güven, Ayla</au><au>Cinaz, Peyami</au><au>Bideci, Aysun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is premature adrenarche a risk factor for atherogenesis?</atitle><jtitle>Pediatrics international</jtitle><addtitle>Pediatr Int</addtitle><date>2005-02</date><risdate>2005</risdate><volume>47</volume><issue>1</issue><spage>20</spage><epage>25</epage><pages>20-25</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Background
: The aim of this study was to evaluate serum lipids and atherosclerosis risk in children with premature adrenarche (PA) in comparison with age‐matched controls.
Methods
: Lipid profile, glucose, insulin, and insulin‐like growth factor binding protein‐1 (IGFBP‐1) levels were studied in 24 girls with premature adrenarche and 13 healthy age‐matched controls after overnight fasting.
Results
: The bone age, weight and body mass index were higher in the premature adrenarche group than the control group. Systolic, diastolic and mean arterial blood pressure of patients were higher than controls. The mean total cholesterol (TC), low‐density lipoprotein‐cholesterol (LDL‐C), very low‐density lipoprotein‐cholesterol (VLDL‐C), TC/high‐density lipoprotein‐cholesterol (HDL‐C) and LDL‐C/HDL‐C ratio, and atherogenic index were significantly higher in the premature adrenarche group compared to the control group. There was no significant difference in the levels of apolipoprotein A1, apolipoprotein B and lipoprotein (a) in both groups. In the premature adrenarche group there were inverse correlations between the levels of IGFBP‐1 and TC/HDL‐C (rho, –0.54; P, 0.011), and LDL‐C/HDL‐C (rho, –0.50; P < 0.05) and atherogenic index (AI; rho, –0.54; P < 0.05). dehydroepiandrosterone sulfate levels of the patients was negatively correlated with AI and TC/HDL‐C (rho, –0.0503, P < 0.05).
Conclusions
: Girls with premature adrenarche should be investigated for serum lipids, and atherogenic risk criteria should be assessed periodically in the follow up of patients with PA, as PA seems to be a risk factor for future atherosclerosis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Pty</pub><pmid>15693861</pmid><doi>10.1111/j.1442-200x.2004.02006.x</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adrenal Glands - secretion Arteriosclerosis - epidemiology atherogenic index Body Size Cardiovascular disease Case-Control Studies Child Cholesterol Comparative studies Female Girls high-density lipoprotein-cholesterol Humans insulin-like growth factor binding protein-1 Lipids - blood low-density lipoprotein-cholesterol Pediatrics premature adrenarche Puberty, Precocious - complications Risk Factors total cholesterol |
| title | Is premature adrenarche a risk factor for atherogenesis? |
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