Target-dependent T-cell Activation by Coligation With a PSMA x CD3 Diabody Induces Lysis of Prostate Cancer Cells

Recently, we have described a bispecific PSMA x CD3 diabody with one binding site for the T-cell antigen receptor (TCR-CD3) and another for the Prostate Specific Membrane Antigen (PSMA). It effectively eliminates human prostate cancer cells by redirecting T-lymphocytes in vitro and in vivo. Here, we...

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Veröffentlicht in:	Journal of immunotherapy (1997) 2009-07, Vol.32 (6), p.565-573
Hauptverfasser:	BÜHLER, Patrick, MOLNAR, Eszter, DOPFER, Elaine P, WOLF, Philipp, GIERSCHNER, Dorothee, WETTERAUER, Ulrich, SCHAMEL, Wolfgang W. A, ELSÄSSER-BEILE, Ursula
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Bispecific - immunology Antibodies, Bispecific - therapeutic use Antineoplastic agents Biological and medical sciences Calcium - metabolism CD3 Complex - immunology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - transplantation CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - transplantation Cell Line, Tumor Cytokines - immunology Fas Ligand Protein - immunology Fas Ligand Protein - metabolism Gynecology. Andrology. Obstetrics Humans Immunotherapy Lymphocyte Activation Male Male genital diseases Medical sciences Nephrology. Urinary tract diseases Perforin - immunology Perforin - metabolism Pharmacology. Drug treatments Prostate-Specific Antigen - immunology Prostatic Neoplasms - immunology Prostatic Neoplasms - therapy Tumors Tumors of the urinary system Up-Regulation Urinary tract. Prostate gland
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