A low frequency of lymph node metastasis in clear‐cell renal cell carcinoma is related to low lymphangiogenic activity

OBJECTIVE To assess ongoing lymphangiogenesis in renal cell carcinoma (RCC) by histomorphometry and by quantifying mRNA expression levels of lymphangiogenesis‐related factors. MATERIALS AND METHODS Using D2‐40 antibody as a lymphatic marker, lymph vessels were counted in tissue sections of 150 clear...

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Veröffentlicht in:	BJU international 2009-06, Vol.103 (12), p.1626-1631
Hauptverfasser:	Baldewijns, Marcella M., Roskams, Tania, Ballet, Vera, Van den Eynden, Gert G., Van Laere, Steven J., Van der Auwera, Ilse, Lerut, Evelyne, De Bruïne, Adriaan P., Thijssen, Victor L., Vermeulen, Peter B., Van Poppel, Hein
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Renal Cell - secondary Female Hematologic and hematopoietic diseases Humans Immunohistochemistry Kidney Neoplasms - pathology Kidneys Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph Nodes - pathology lymphangiogenesis Lymphangiogenesis - physiology Lymphatic Metastasis Lymphatic Vessels - pathology Male Medical sciences Membrane Glycoproteins - metabolism Middle Aged Nephrology. Urinary tract diseases podoplanin prox‐1 renal carcinoma Reverse Transcriptase Polymerase Chain Reaction Tumors of the urinary system Vascular Endothelial Growth Factor Receptor-3 - metabolism Vascular Endothelial Growth Factors - metabolism VEGF Young Adult
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