The immunomodulator FTY720 interferes with effector functions of human monocyte‐derived dendritic cells

The potent immunomodulator FTY720 elicits immunosuppression via acting on sphingosine 1‐phosphate receptors (S1PR), thereby leading to an entrapment of lymphocytes in the secondary lymphoid tissue. To elucidate the potential in vitro effects of this drug on human monocyte‐derived DC, we used low nan...

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Veröffentlicht in:	European Journal of Immunology 2005-02, Vol.35 (2), p.533-545
Hauptverfasser:	Müller, Hansgeorg, Hofer, Susanne, Kaneider, Nicole, Neuwirt, Hannes, Mosheimer, Birgit, Mayer, Gert, Konwalinka, Günther, Heufler, Christine, Tiefenthaler, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism CD18 Antigens - genetics CD18 Antigens - immunology CD40 Antigens - immunology Chemokines - metabolism Chemotaxis Chemotaxis - physiology Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - metabolism Fingolimod Hydrochloride Gene Expression - drug effects Humans Immunosuppressive Agents - pharmacology Interferon-gamma - metabolism Interleukin-10 - metabolism Interleukin-4 - metabolism Propylene Glycols - pharmacology Sphingolipids Sphingosine - analogs & derivatives T-Lymphocytes - drug effects T-Lymphocytes - metabolism Time Factors Tolerance Transplantation
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