Functional Cross-talk between Fatty Acid Synthesis and Nonribosomal Peptide Synthesis in Quinoxaline Antibiotic-producing Streptomycetes

Quinoxaline antibiotics are chromopeptide lactones embracing the two families of triostins and quinomycins, each having characteristic sulfur-containing cross-bridges. Interest in these compounds stems from their antineoplastic activities and their specific binding to DNA via bifunctional intercalat...

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Veröffentlicht in:	The Journal of biological chemistry 2005-02, Vol.280 (6), p.4339-4349
Hauptverfasser:	Schmoock, Gernot, Pfennig, Frank, Jewiarz, Julien, Schlumbohm, Wilhelm, Laubinger, Werner, Schauwecker, Florian, Keller, Ullrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry Binding Sites Carboxylic Acids - chemistry Chromatography, Thin Layer Cloning, Molecular DNA - metabolism Echinomycin - chemistry Electrophoresis, Polyacrylamide Gel Escherichia coli - metabolism Fatty Acid Synthases - metabolism Genome Kinetics Lactones - chemistry Models, Chemical Molecular Sequence Data Peptide Biosynthesis Peptide Biosynthesis, Nucleic Acid-Independent Peptides - chemistry Plasmids - metabolism Protein Binding Protein Structure, Tertiary Quinoxalines - chemistry Quinoxalines - metabolism Recombinant Proteins - chemistry Sequence Homology, Amino Acid Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Streptomyces Streptomyces - metabolism Streptomyces lividans - metabolism Substrate Specificity Valine - chemistry
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