The Liver X Receptor Ligand T0901317 Decreases Amyloid β Production in Vitro and in a Mouse Model of Alzheimer's Disease

Recent studies indicate that oxysterols, which are ligands for the nuclear hormone liver X receptors (LXR), decrease amyloid β (Aβ) secretion in vitro. The effect was attributed primarily to the ATP-binding cassette transporter A1 (ABCA1) transcriptionally up-regulated by ligand-activated LXRs. We n...

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Veröffentlicht in:	The Journal of biological chemistry 2005-02, Vol.280 (6), p.4079-4088
Hauptverfasser:	Koldamova, Radosveta P., Lefterov, Iliya M., Staufenbiel, Matthias, Wolfe, Darren, Huang, Shaohua, Glorioso, Joseph C., Walter, Michael, Roth, Michael G., Lazo, John S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Amyloid beta-Protein Precursor - genetics Animals Anticholesteremic Agents - pharmacology Apolipoprotein A-I - chemistry Blotting, Western Brain - metabolism Cloning, Molecular Disease Models, Animal DNA, Complementary - metabolism DNA-Binding Proteins Enzyme-Linked Immunosorbent Assay Fibroblasts - metabolism Humans Hydrocarbons, Fluorinated Immunoprecipitation Ligands Liver X Receptors Mice Mice, Inbred C57BL Mice, Transgenic Neurons - metabolism Orphan Nuclear Receptors Protein Binding Receptors, Cytoplasmic and Nuclear - metabolism Simplexvirus - metabolism Sulfonamides Time Factors Transcription, Genetic Transfection Up-Regulation
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