Impaired Ca2+ Store Functions in Skeletal and Cardiac Muscle Cells from Sarcalumenin-deficient Mice

Sarcalumenin (SAR), specifically expressed in striated muscle cells, is a Ca2+-binding protein localized in the sarcoplasmic reticulum (SR) of the intracellular Ca2+ store. By generating SAR-deficient mice, we herein examined its physiological role. The mutant mice were apparently normal in growth,...

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Veröffentlicht in:	The Journal of biological chemistry 2005-02, Vol.280 (5), p.3500-3506
Hauptverfasser:	Yoshida, Morikatsu, Minamisawa, Susumu, Shimura, Miei, Komazaki, Shinji, Kume, Hideaki, Zhang, Miao, Matsumura, Kiyoyuki, Nishi, Miyuki, Saito, Minori, Saeki, Yasutake, Ishikawa, Yoshihiro, Yanagisawa, Teruyuki, Takeshima, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Heart - physiopathology Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Electron Muscle Contraction Muscle Fibers, Skeletal - metabolism Muscle Fibers, Skeletal - pathology Muscle Fibers, Skeletal - ultrastructure Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Myocardial Contraction Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Myocytes, Cardiac - ultrastructure Rats
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