Hepatocellular lesions with increased iron uptake on superparamagnetic iron oxide-enhanced magnetic resonance imaging in cirrhosis or chronic hepatitis: comparison of four magnetic resonance sequences for lesion conspicuity
Abstract Purpose The aim of this study was to determine the adequate MR sequence for the lesion conspicuity of hepatocellular lesions with increased iron uptake on superparamagnetic iron oxide (SPIO)-enhanced MRI. Materials and Methods SPIO-enhanced MRI was performed using a 1.5-T system. Among 25 p...
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| Veröffentlicht in: | Magnetic resonance imaging 2009-07, Vol.27 (6), p.801-806 |
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| description | Abstract Purpose The aim of this study was to determine the adequate MR sequence for the lesion conspicuity of hepatocellular lesions with increased iron uptake on superparamagnetic iron oxide (SPIO)-enhanced MRI. Materials and Methods SPIO-enhanced MRI was performed using a 1.5-T system. Among 25 patients with hypovascular hepatocellular nodules on contrast-enhanced dynamic CT (no early enhancement at arterial phase and hypoattenuation at equilibrium phase), 39 lesions with increased iron uptake on SPIO-enhanced MRI were evaluated. SPIO-enhanced MRI included (1) T1-weighted in-phase gradient recalled echo (GRE) images, (2) T2-weighted fast spin echo (FSE) images, (3) T2*-weighted GRE with moderate TE (7 ms) and (4) long TE (12 ms). The lesion-to-liver contrast-to-noise ratios of the hepatocellular nodule and the signal-to-noise ratio (SNR) of the hepatic parenchyma were calculated by one radiologist for a quantitative assessment. MR images were reviewed retrospectively by two independent radiologists to compare the subjective lesion conspicuity in each image set based on a four-point rating scale. Result The mean lesion-to-liver contrast-to-noise ratios with T2*-weighted GRE with moderate TE (7 ms) was highest (5.79±3.71) and was significantly higher than those with T1-weighted, in-phase images (3.79±3.23, P |
| doi_str_mv | 10.1016/j.mri.2008.11.006 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67407665</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0730725X08003688</els_id><sourcerecordid>67407665</sourcerecordid><originalsourceid>FETCH-LOGICAL-c406t-8272aed53e352ecfab67105dfd8585ea8bbd6199a87c6e2bf0f29923a2c5e7413</originalsourceid><addsrcrecordid>eNp9UtGK1DAULaK44-oH-CJ58q1jkjZtqiDI4rrCgg8q-BbS9HbnzrZJzW3V-dr9FVNmVBDxKZebc05uzrlZ9lTwreCierHfjhG3knO9FWLLeXUv2whdF7nSTXk_2_C64Hkt1Zez7BHRnnOuZKEeZmeiEWVZ6nqT3V3BZOfgYBiWwUY2AGHwxL7jvGPoXQRL0DGMwbNlmu0tsFTRMkGcbLSjvfEwozsCwg_sIAe_s94l0u_LCBT82mOYeuhvkjJzGOMuEBILkbld4ifkbp0GZ6SXzIUxvYC06vasD0v8lyDB1wVSQQnxa_pE9TShW3A-PM4e9HYgeHI6z7PPl28_XVzl1x_evb94c527kldzrmUtLXSqgEJJcL1tq1pw1fWdVlqB1W3bVaJprK5dBbLteS-bRhZWOgV1KYrz7PlRd4ohTUSzGZFWV62HsJCp6pLXVaUSUByBLgaiCL2ZYnIlHozgZk3V7E1K1aypGiFMSjVxnp3El3aE7g_jFGMCvDoCIH3xG0I05HC1pcMIbjZdwP_Kv_6L7QZMadjhFg5A-2S9T94ZYUgabj6ua7VuFdecF5XWxU_uo9By</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67407665</pqid></control><display><type>article</type><title>Hepatocellular lesions with increased iron uptake on superparamagnetic iron oxide-enhanced magnetic resonance imaging in cirrhosis or chronic hepatitis: comparison of four magnetic resonance sequences for lesion conspicuity</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Tanabe, Masahiro ; Ito, Katsuyoshi ; Shimizu, Ayame ; Fujita, Takeshi ; Onoda, Hideko ; Yamatogi, Shigenari ; Washida, Yasuo ; Matsunaga, Naofumi</creator><creatorcontrib>Tanabe, Masahiro ; Ito, Katsuyoshi ; Shimizu, Ayame ; Fujita, Takeshi ; Onoda, Hideko ; Yamatogi, Shigenari ; Washida, Yasuo ; Matsunaga, Naofumi</creatorcontrib><description>Abstract Purpose The aim of this study was to determine the adequate MR sequence for the lesion conspicuity of hepatocellular lesions with increased iron uptake on superparamagnetic iron oxide (SPIO)-enhanced MRI. Materials and Methods SPIO-enhanced MRI was performed using a 1.5-T system. Among 25 patients with hypovascular hepatocellular nodules on contrast-enhanced dynamic CT (no early enhancement at arterial phase and hypoattenuation at equilibrium phase), 39 lesions with increased iron uptake on SPIO-enhanced MRI were evaluated. SPIO-enhanced MRI included (1) T1-weighted in-phase gradient recalled echo (GRE) images, (2) T2-weighted fast spin echo (FSE) images, (3) T2*-weighted GRE with moderate TE (7 ms) and (4) long TE (12 ms). The lesion-to-liver contrast-to-noise ratios of the hepatocellular nodule and the signal-to-noise ratio (SNR) of the hepatic parenchyma were calculated by one radiologist for a quantitative assessment. MR images were reviewed retrospectively by two independent radiologists to compare the subjective lesion conspicuity in each image set based on a four-point rating scale. Result The mean lesion-to-liver contrast-to-noise ratios with T2*-weighted GRE with moderate TE (7 ms) was highest (5.79±3.71) and was significantly higher than those with T1-weighted, in-phase images (3.79±3.23, P <.01), T2-weighted images (2.72±1.52, P <.001) and T2*-weighted GRE with long TE (12 ms) (3.93±2.69, P <.05). The subjective rating of lesion conspicuity was best on the T2*-weighted GRE with moderate TE (7 ms), followed by that on the T2*-weighted GRE with moderate TE (7 ms; P <.05). Conclusion T2*-weighted GRE sequence with moderate TE (7 ms) showed high lesion-to-liver contrast-to-noise ratios in hepatocellular lesions with increased iron uptake on SPIO-enhanced MRI, indicating better lesion conspicuity of hypointense hepatocellular nodules in cirrhosis or chronic hepatitis.</description><identifier>ISSN: 0730-725X</identifier><identifier>EISSN: 1873-5894</identifier><identifier>DOI: 10.1016/j.mri.2008.11.006</identifier><identifier>PMID: 19144487</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adequate MR sequence ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - metabolism ; Chronic Disease ; Contrast Media - pharmacokinetics ; Dextrans ; Dysplastic nodule ; Female ; Ferrosoferric Oxide ; Hepatitis - diagnosis ; Hepatitis - metabolism ; Humans ; Image Enhancement - methods ; Iron - pharmacokinetics ; Liver Cirrhosis - diagnosis ; Liver Cirrhosis - metabolism ; Liver Neoplasms - diagnosis ; Liver Neoplasms - metabolism ; Magnetite Nanoparticles ; Male ; Middle Aged ; Oxides - pharmacokinetics ; Radiology ; Reproducibility of Results ; Sensitivity and Specificity ; SPIO-enhanced MRI ; Well-differentiated hepatocellular carcinoma</subject><ispartof>Magnetic resonance imaging, 2009-07, Vol.27 (6), p.801-806</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-8272aed53e352ecfab67105dfd8585ea8bbd6199a87c6e2bf0f29923a2c5e7413</citedby><cites>FETCH-LOGICAL-c406t-8272aed53e352ecfab67105dfd8585ea8bbd6199a87c6e2bf0f29923a2c5e7413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0730725X08003688$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19144487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanabe, Masahiro</creatorcontrib><creatorcontrib>Ito, Katsuyoshi</creatorcontrib><creatorcontrib>Shimizu, Ayame</creatorcontrib><creatorcontrib>Fujita, Takeshi</creatorcontrib><creatorcontrib>Onoda, Hideko</creatorcontrib><creatorcontrib>Yamatogi, Shigenari</creatorcontrib><creatorcontrib>Washida, Yasuo</creatorcontrib><creatorcontrib>Matsunaga, Naofumi</creatorcontrib><title>Hepatocellular lesions with increased iron uptake on superparamagnetic iron oxide-enhanced magnetic resonance imaging in cirrhosis or chronic hepatitis: comparison of four magnetic resonance sequences for lesion conspicuity</title><title>Magnetic resonance imaging</title><addtitle>Magn Reson Imaging</addtitle><description>Abstract Purpose The aim of this study was to determine the adequate MR sequence for the lesion conspicuity of hepatocellular lesions with increased iron uptake on superparamagnetic iron oxide (SPIO)-enhanced MRI. Materials and Methods SPIO-enhanced MRI was performed using a 1.5-T system. Among 25 patients with hypovascular hepatocellular nodules on contrast-enhanced dynamic CT (no early enhancement at arterial phase and hypoattenuation at equilibrium phase), 39 lesions with increased iron uptake on SPIO-enhanced MRI were evaluated. SPIO-enhanced MRI included (1) T1-weighted in-phase gradient recalled echo (GRE) images, (2) T2-weighted fast spin echo (FSE) images, (3) T2*-weighted GRE with moderate TE (7 ms) and (4) long TE (12 ms). The lesion-to-liver contrast-to-noise ratios of the hepatocellular nodule and the signal-to-noise ratio (SNR) of the hepatic parenchyma were calculated by one radiologist for a quantitative assessment. MR images were reviewed retrospectively by two independent radiologists to compare the subjective lesion conspicuity in each image set based on a four-point rating scale. Result The mean lesion-to-liver contrast-to-noise ratios with T2*-weighted GRE with moderate TE (7 ms) was highest (5.79±3.71) and was significantly higher than those with T1-weighted, in-phase images (3.79±3.23, P <.01), T2-weighted images (2.72±1.52, P <.001) and T2*-weighted GRE with long TE (12 ms) (3.93±2.69, P <.05). The subjective rating of lesion conspicuity was best on the T2*-weighted GRE with moderate TE (7 ms), followed by that on the T2*-weighted GRE with moderate TE (7 ms; P <.05). Conclusion T2*-weighted GRE sequence with moderate TE (7 ms) showed high lesion-to-liver contrast-to-noise ratios in hepatocellular lesions with increased iron uptake on SPIO-enhanced MRI, indicating better lesion conspicuity of hypointense hepatocellular nodules in cirrhosis or chronic hepatitis.</description><subject>Adequate MR sequence</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Chronic Disease</subject><subject>Contrast Media - pharmacokinetics</subject><subject>Dextrans</subject><subject>Dysplastic nodule</subject><subject>Female</subject><subject>Ferrosoferric Oxide</subject><subject>Hepatitis - diagnosis</subject><subject>Hepatitis - metabolism</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Iron - pharmacokinetics</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Liver Cirrhosis - metabolism</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - metabolism</subject><subject>Magnetite Nanoparticles</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxides - pharmacokinetics</subject><subject>Radiology</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>SPIO-enhanced MRI</subject><subject>Well-differentiated hepatocellular carcinoma</subject><issn>0730-725X</issn><issn>1873-5894</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UtGK1DAULaK44-oH-CJ58q1jkjZtqiDI4rrCgg8q-BbS9HbnzrZJzW3V-dr9FVNmVBDxKZebc05uzrlZ9lTwreCierHfjhG3knO9FWLLeXUv2whdF7nSTXk_2_C64Hkt1Zez7BHRnnOuZKEeZmeiEWVZ6nqT3V3BZOfgYBiWwUY2AGHwxL7jvGPoXQRL0DGMwbNlmu0tsFTRMkGcbLSjvfEwozsCwg_sIAe_s94l0u_LCBT82mOYeuhvkjJzGOMuEBILkbld4ifkbp0GZ6SXzIUxvYC06vasD0v8lyDB1wVSQQnxa_pE9TShW3A-PM4e9HYgeHI6z7PPl28_XVzl1x_evb94c527kldzrmUtLXSqgEJJcL1tq1pw1fWdVlqB1W3bVaJprK5dBbLteS-bRhZWOgV1KYrz7PlRd4ohTUSzGZFWV62HsJCp6pLXVaUSUByBLgaiCL2ZYnIlHozgZk3V7E1K1aypGiFMSjVxnp3El3aE7g_jFGMCvDoCIH3xG0I05HC1pcMIbjZdwP_Kv_6L7QZMadjhFg5A-2S9T94ZYUgabj6ua7VuFdecF5XWxU_uo9By</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Tanabe, Masahiro</creator><creator>Ito, Katsuyoshi</creator><creator>Shimizu, Ayame</creator><creator>Fujita, Takeshi</creator><creator>Onoda, Hideko</creator><creator>Yamatogi, Shigenari</creator><creator>Washida, Yasuo</creator><creator>Matsunaga, Naofumi</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Hepatocellular lesions with increased iron uptake on superparamagnetic iron oxide-enhanced magnetic resonance imaging in cirrhosis or chronic hepatitis: comparison of four magnetic resonance sequences for lesion conspicuity</title><author>Tanabe, Masahiro ; Ito, Katsuyoshi ; Shimizu, Ayame ; Fujita, Takeshi ; Onoda, Hideko ; Yamatogi, Shigenari ; Washida, Yasuo ; Matsunaga, Naofumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-8272aed53e352ecfab67105dfd8585ea8bbd6199a87c6e2bf0f29923a2c5e7413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adequate MR sequence</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Chronic Disease</topic><topic>Contrast Media - pharmacokinetics</topic><topic>Dextrans</topic><topic>Dysplastic nodule</topic><topic>Female</topic><topic>Ferrosoferric Oxide</topic><topic>Hepatitis - diagnosis</topic><topic>Hepatitis - metabolism</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Iron - pharmacokinetics</topic><topic>Liver Cirrhosis - diagnosis</topic><topic>Liver Cirrhosis - metabolism</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - metabolism</topic><topic>Magnetite Nanoparticles</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxides - pharmacokinetics</topic><topic>Radiology</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>SPIO-enhanced MRI</topic><topic>Well-differentiated hepatocellular carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanabe, Masahiro</creatorcontrib><creatorcontrib>Ito, Katsuyoshi</creatorcontrib><creatorcontrib>Shimizu, Ayame</creatorcontrib><creatorcontrib>Fujita, Takeshi</creatorcontrib><creatorcontrib>Onoda, Hideko</creatorcontrib><creatorcontrib>Yamatogi, Shigenari</creatorcontrib><creatorcontrib>Washida, Yasuo</creatorcontrib><creatorcontrib>Matsunaga, Naofumi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanabe, Masahiro</au><au>Ito, Katsuyoshi</au><au>Shimizu, Ayame</au><au>Fujita, Takeshi</au><au>Onoda, Hideko</au><au>Yamatogi, Shigenari</au><au>Washida, Yasuo</au><au>Matsunaga, Naofumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatocellular lesions with increased iron uptake on superparamagnetic iron oxide-enhanced magnetic resonance imaging in cirrhosis or chronic hepatitis: comparison of four magnetic resonance sequences for lesion conspicuity</atitle><jtitle>Magnetic resonance imaging</jtitle><addtitle>Magn Reson Imaging</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>27</volume><issue>6</issue><spage>801</spage><epage>806</epage><pages>801-806</pages><issn>0730-725X</issn><eissn>1873-5894</eissn><abstract>Abstract Purpose The aim of this study was to determine the adequate MR sequence for the lesion conspicuity of hepatocellular lesions with increased iron uptake on superparamagnetic iron oxide (SPIO)-enhanced MRI. Materials and Methods SPIO-enhanced MRI was performed using a 1.5-T system. Among 25 patients with hypovascular hepatocellular nodules on contrast-enhanced dynamic CT (no early enhancement at arterial phase and hypoattenuation at equilibrium phase), 39 lesions with increased iron uptake on SPIO-enhanced MRI were evaluated. SPIO-enhanced MRI included (1) T1-weighted in-phase gradient recalled echo (GRE) images, (2) T2-weighted fast spin echo (FSE) images, (3) T2*-weighted GRE with moderate TE (7 ms) and (4) long TE (12 ms). The lesion-to-liver contrast-to-noise ratios of the hepatocellular nodule and the signal-to-noise ratio (SNR) of the hepatic parenchyma were calculated by one radiologist for a quantitative assessment. MR images were reviewed retrospectively by two independent radiologists to compare the subjective lesion conspicuity in each image set based on a four-point rating scale. Result The mean lesion-to-liver contrast-to-noise ratios with T2*-weighted GRE with moderate TE (7 ms) was highest (5.79±3.71) and was significantly higher than those with T1-weighted, in-phase images (3.79±3.23, P <.01), T2-weighted images (2.72±1.52, P <.001) and T2*-weighted GRE with long TE (12 ms) (3.93±2.69, P <.05). The subjective rating of lesion conspicuity was best on the T2*-weighted GRE with moderate TE (7 ms), followed by that on the T2*-weighted GRE with moderate TE (7 ms; P <.05). Conclusion T2*-weighted GRE sequence with moderate TE (7 ms) showed high lesion-to-liver contrast-to-noise ratios in hepatocellular lesions with increased iron uptake on SPIO-enhanced MRI, indicating better lesion conspicuity of hypointense hepatocellular nodules in cirrhosis or chronic hepatitis.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>19144487</pmid><doi>10.1016/j.mri.2008.11.006</doi><tpages>6</tpages></addata></record> |
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| subjects | Adequate MR sequence Aged Aged, 80 and over Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - metabolism Chronic Disease Contrast Media - pharmacokinetics Dextrans Dysplastic nodule Female Ferrosoferric Oxide Hepatitis - diagnosis Hepatitis - metabolism Humans Image Enhancement - methods Iron - pharmacokinetics Liver Cirrhosis - diagnosis Liver Cirrhosis - metabolism Liver Neoplasms - diagnosis Liver Neoplasms - metabolism Magnetite Nanoparticles Male Middle Aged Oxides - pharmacokinetics Radiology Reproducibility of Results Sensitivity and Specificity SPIO-enhanced MRI Well-differentiated hepatocellular carcinoma |
| title | Hepatocellular lesions with increased iron uptake on superparamagnetic iron oxide-enhanced magnetic resonance imaging in cirrhosis or chronic hepatitis: comparison of four magnetic resonance sequences for lesion conspicuity |
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