S100B Increases Proliferation in PC12 Neuronal Cells and Reduces Their Responsiveness to Nerve Growth Factor via Akt Activation

S100B is a Ca2+-modulated protein of the EF-hand type expressed in high abundance in a restricted set of cell types including certain neuronal populations. S100B has been suggested to participate in cell cycle progression, and S100B levels are high in tumor cells, compared with normal parental cells...

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Veröffentlicht in:	The Journal of biological chemistry 2005-02, Vol.280 (6), p.4402-4414
Hauptverfasser:	Arcuri, Cataldo, Bianchi, Roberta, Brozzi, Flora, Donato, Rosario
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Blotting, Western Cell Cycle Cell Cycle Proteins - metabolism Cell Differentiation Cell Proliferation Cell Separation Cell Survival Chromones - pharmacology Cyclin D1 - metabolism Cyclin-Dependent Kinase Inhibitor p21 Doxycycline - pharmacology Enzyme Activation Flow Cytometry Immunoprecipitation Luciferases - metabolism Microscopy, Fluorescence Morpholines - pharmacology Nerve Growth Factor - metabolism Nerve Growth Factors - metabolism Nerve Growth Factors - physiology Neurons - metabolism PC12 Cells Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Rats Retinoblastoma Protein - metabolism Reverse Transcriptase Polymerase Chain Reaction S100 Calcium Binding Protein beta Subunit S100 Proteins - metabolism S100 Proteins - physiology Time Factors Transfection Tumor Suppressor Protein p53 - metabolism
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