Synthesis, in vitro cytotoxic and antiviral activity of cis-[Pt(R(–) and S(+)-2-α-hydroxybenzylbenzimidazole) 2Cl 2] complexes
A pair of enantiomeric platinum(II) complexes of cis-[Pt(R(–) and S(+)-HBB) 2Cl 2] (HBB = 2-α-hydroxybenzylbenzimidazole) was synthesized and evaluated for its preliminary in vitro cytotoxic activity on the human MCF-7 breast cancer and HeLa cervix cancer cell lines and antiherpes virus activity aga...
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| Veröffentlicht in: | European journal of medicinal chemistry 2005-02, Vol.40 (2), p.135-141 |
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| container_title | European journal of medicinal chemistry |
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| creator | Gökçe, M. Utku, S. Gür, S. Özkul, A. Gümüş, F. |
| description | A pair of enantiomeric platinum(II) complexes of
cis-[Pt(R(–) and S(+)-HBB)
2Cl
2] (HBB = 2-α-hydroxybenzylbenzimidazole) was synthesized and evaluated for its preliminary in vitro cytotoxic activity on the human MCF-7 breast cancer and HeLa cervix cancer cell lines and antiherpes virus activity against bovine herpesvirus type 1 (BHV-1). In general, it was found that Pt(II) complexes were less cytotoxic on both cell lines than cisplatin and were comparable to carboplatin. There was no significant difference in cytotoxicity between two enantiomers, and the antiviral test results showed that the Pt(II) complexes and their carrier ligands R(–) and S(+) HBB had no effects inhibiting replication of BHV-1. |
| doi_str_mv | 10.1016/j.ejmech.2004.09.017 |
| format | Article |
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cis-[Pt(R(–) and S(+)-HBB)
2Cl
2] (HBB = 2-α-hydroxybenzylbenzimidazole) was synthesized and evaluated for its preliminary in vitro cytotoxic activity on the human MCF-7 breast cancer and HeLa cervix cancer cell lines and antiherpes virus activity against bovine herpesvirus type 1 (BHV-1). In general, it was found that Pt(II) complexes were less cytotoxic on both cell lines than cisplatin and were comparable to carboplatin. There was no significant difference in cytotoxicity between two enantiomers, and the antiviral test results showed that the Pt(II) complexes and their carrier ligands R(–) and S(+) HBB had no effects inhibiting replication of BHV-1.</description><identifier>ISSN: 0223-5234</identifier><identifier>EISSN: 1768-3254</identifier><identifier>DOI: 10.1016/j.ejmech.2004.09.017</identifier><identifier>PMID: 15694648</identifier><identifier>CODEN: EJMCA5</identifier><language>eng</language><publisher>Oxford: Elsevier Masson SAS</publisher><subject>2-α-Hydroxybenzylbenzimidazole ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antineoplastic agents ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - pharmacology ; Antiviral activity ; Antiviral agents ; Antiviral Agents - chemical synthesis ; Antiviral Agents - pharmacology ; Benzimidazoles - chemical synthesis ; Benzimidazoles - pharmacology ; Biological and medical sciences ; Cattle ; Cisplatin - pharmacology ; Cytotoxic activity ; Drug Screening Assays, Antitumor ; Female ; General aspects ; Herpesvirus 1, Bovine - drug effects ; Humans ; Ligands ; Medical sciences ; Molecular Structure ; Organoplatinum Compounds - chemical synthesis ; Organoplatinum Compounds - pharmacology ; Pharmacology. Drug treatments ; Pt(II) complexes ; Stereoisomerism ; Tumor Cells, Cultured</subject><ispartof>European journal of medicinal chemistry, 2005-02, Vol.40 (2), p.135-141</ispartof><rights>2004 Elsevier SAS</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-a8f0e6f3450c73a181c0a4ae4e396e4309da88ffe34db1337f4e1232068e79593</citedby><cites>FETCH-LOGICAL-c390t-a8f0e6f3450c73a181c0a4ae4e396e4309da88ffe34db1337f4e1232068e79593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0223523404002004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16517694$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15694648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gökçe, M.</creatorcontrib><creatorcontrib>Utku, S.</creatorcontrib><creatorcontrib>Gür, S.</creatorcontrib><creatorcontrib>Özkul, A.</creatorcontrib><creatorcontrib>Gümüş, F.</creatorcontrib><title>Synthesis, in vitro cytotoxic and antiviral activity of cis-[Pt(R(–) and S(+)-2-α-hydroxybenzylbenzimidazole) 2Cl 2] complexes</title><title>European journal of medicinal chemistry</title><addtitle>Eur J Med Chem</addtitle><description>A pair of enantiomeric platinum(II) complexes of
cis-[Pt(R(–) and S(+)-HBB)
2Cl
2] (HBB = 2-α-hydroxybenzylbenzimidazole) was synthesized and evaluated for its preliminary in vitro cytotoxic activity on the human MCF-7 breast cancer and HeLa cervix cancer cell lines and antiherpes virus activity against bovine herpesvirus type 1 (BHV-1). In general, it was found that Pt(II) complexes were less cytotoxic on both cell lines than cisplatin and were comparable to carboplatin. There was no significant difference in cytotoxicity between two enantiomers, and the antiviral test results showed that the Pt(II) complexes and their carrier ligands R(–) and S(+) HBB had no effects inhibiting replication of BHV-1.</description><subject>2-α-Hydroxybenzylbenzimidazole</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antiviral activity</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - chemical synthesis</subject><subject>Antiviral Agents - pharmacology</subject><subject>Benzimidazoles - chemical synthesis</subject><subject>Benzimidazoles - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Cisplatin - pharmacology</subject><subject>Cytotoxic activity</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Female</subject><subject>General aspects</subject><subject>Herpesvirus 1, Bovine - drug effects</subject><subject>Humans</subject><subject>Ligands</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Organoplatinum Compounds - chemical synthesis</subject><subject>Organoplatinum Compounds - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pt(II) complexes</subject><subject>Stereoisomerism</subject><subject>Tumor Cells, Cultured</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KE0EQgBtR3OzqG4j0RUnQidU_0zNzEST4BwuKqyeRptNTQzrMTMfuTsjsaX0Gn8QX8SF8EicmsDcP9XP4qii-IuQRgzkDpl6s57ju0K7mHEDOoZoDK-6QCStUmQmey7tkApyLLOdCnpHzGNcAkCuA--SM5aqSSpYT8uNq6NMKo4vPqevpzqXgqR2ST37vLDV9PUZyOxdMS409dGmgvqHWxezrxzT9NP1z83P2D7yaPptlPPv9K1sNdfD7YYn99dAesutcba59izPKFy3l36j13abFPcYH5F5j2ogPT_WCfHnz-vPiXXb54e37xavLzIoKUmbKBlA1QuZgC2FYySwYaVCiqBRKAVVtyrJpUMh6yYQoGomMCw6qxKLKK3FBnh73boL_vsWYdOeixbY1Pfpt1KqQUORSjKA8gjb4GAM2ehNcZ8KgGeiDer3WR_X6oF5DpUf149jj0_7tssP6dujkegSenAATrWmbYPpR4i2n8vF3lRy5l0cORxs7h0FH67C3WLuANunau_9f8hckEqUG</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Gökçe, M.</creator><creator>Utku, S.</creator><creator>Gür, S.</creator><creator>Özkul, A.</creator><creator>Gümüş, F.</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050201</creationdate><title>Synthesis, in vitro cytotoxic and antiviral activity of cis-[Pt(R(–) and S(+)-2-α-hydroxybenzylbenzimidazole) 2Cl 2] complexes</title><author>Gökçe, M. ; Utku, S. ; Gür, S. ; Özkul, A. ; Gümüş, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-a8f0e6f3450c73a181c0a4ae4e396e4309da88ffe34db1337f4e1232068e79593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>2-α-Hydroxybenzylbenzimidazole</topic><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antiviral activity</topic><topic>Antiviral agents</topic><topic>Antiviral Agents - chemical synthesis</topic><topic>Antiviral Agents - pharmacology</topic><topic>Benzimidazoles - chemical synthesis</topic><topic>Benzimidazoles - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Cisplatin - pharmacology</topic><topic>Cytotoxic activity</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Female</topic><topic>General aspects</topic><topic>Herpesvirus 1, Bovine - drug effects</topic><topic>Humans</topic><topic>Ligands</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Organoplatinum Compounds - chemical synthesis</topic><topic>Organoplatinum Compounds - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pt(II) complexes</topic><topic>Stereoisomerism</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gökçe, M.</creatorcontrib><creatorcontrib>Utku, S.</creatorcontrib><creatorcontrib>Gür, S.</creatorcontrib><creatorcontrib>Özkul, A.</creatorcontrib><creatorcontrib>Gümüş, F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gökçe, M.</au><au>Utku, S.</au><au>Gür, S.</au><au>Özkul, A.</au><au>Gümüş, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, in vitro cytotoxic and antiviral activity of cis-[Pt(R(–) and S(+)-2-α-hydroxybenzylbenzimidazole) 2Cl 2] complexes</atitle><jtitle>European journal of medicinal chemistry</jtitle><addtitle>Eur J Med Chem</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>40</volume><issue>2</issue><spage>135</spage><epage>141</epage><pages>135-141</pages><issn>0223-5234</issn><eissn>1768-3254</eissn><coden>EJMCA5</coden><abstract>A pair of enantiomeric platinum(II) complexes of
cis-[Pt(R(–) and S(+)-HBB)
2Cl
2] (HBB = 2-α-hydroxybenzylbenzimidazole) was synthesized and evaluated for its preliminary in vitro cytotoxic activity on the human MCF-7 breast cancer and HeLa cervix cancer cell lines and antiherpes virus activity against bovine herpesvirus type 1 (BHV-1). In general, it was found that Pt(II) complexes were less cytotoxic on both cell lines than cisplatin and were comparable to carboplatin. There was no significant difference in cytotoxicity between two enantiomers, and the antiviral test results showed that the Pt(II) complexes and their carrier ligands R(–) and S(+) HBB had no effects inhibiting replication of BHV-1.</abstract><cop>Oxford</cop><pub>Elsevier Masson SAS</pub><pmid>15694648</pmid><doi>10.1016/j.ejmech.2004.09.017</doi><tpages>7</tpages></addata></record> |
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| subjects | 2-α-Hydroxybenzylbenzimidazole Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antiviral activity Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Benzimidazoles - chemical synthesis Benzimidazoles - pharmacology Biological and medical sciences Cattle Cisplatin - pharmacology Cytotoxic activity Drug Screening Assays, Antitumor Female General aspects Herpesvirus 1, Bovine - drug effects Humans Ligands Medical sciences Molecular Structure Organoplatinum Compounds - chemical synthesis Organoplatinum Compounds - pharmacology Pharmacology. Drug treatments Pt(II) complexes Stereoisomerism Tumor Cells, Cultured |
| title | Synthesis, in vitro cytotoxic and antiviral activity of cis-[Pt(R(–) and S(+)-2-α-hydroxybenzylbenzimidazole) 2Cl 2] complexes |
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