Menin Suppresses Osteoblast Differentiation by Antagonizing the AP-1 Factor, JunD

Mice null for menin, the product of the multiple endocrine neoplasia type 1 (MEN1) gene, exhibit cranial and facial hypoplasia suggesting a role for menin in bone formation. We have shown previously that menin is required for the commitment of multipotential mesenchymal stem cells into the osteoblas...

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Veröffentlicht in:	The Journal of biological chemistry 2005-02, Vol.280 (6), p.4785-4791
Hauptverfasser:	Naito, Junko, Kaji, Hiroshi, Sowa, Hideaki, Hendy, Geoffrey N., Sugimoto, Toshitsugu, Chihara, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Animals Blotting, Northern Blotting, Western Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins - metabolism Cell Differentiation Cell Line DNA, Complementary - metabolism Humans Immunoprecipitation Luciferases - metabolism Mice Oligonucleotides, Antisense - chemistry Osteoblasts - cytology Osteoblasts - metabolism Plasmids - metabolism Protein Binding Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-jun - metabolism Proto-Oncogene Proteins c-jun - physiology Reverse Transcriptase Polymerase Chain Reaction RNA - chemistry Signal Transduction Transcription Factor AP-1 - metabolism Transcription, Genetic Transfection Transforming Growth Factor beta - metabolism
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