Bleomycin A5 plus dexamethasone for control of growth in infantile parotid hemangiomas
Objective The purpose of this study was to evaluate the efficacy of bleomycin A5 (pingyangmycin) plus dexamethasone for control of growth in infantile parotid hemangiomas. Study design We reviewed and analyzed the data of 31 cases undergoing therapy of intralesional injection with small-dosage and l...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2009-07, Vol.108 (1), p.62-69 |
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| creator | Yang, Yaowu, DDS, PhD Sun, Moyi, DDS, PhD Cheng, Xiaobing, DDS, PhD Hu, Xiaoguang, DDS Zhang, Pu, DDS, PhD Ma, Qin, DDS, PhD Li, Jianhu, DDS Tian, Lei, DDS, PhD Lei, Delin, DDS |
| description | Objective The purpose of this study was to evaluate the efficacy of bleomycin A5 (pingyangmycin) plus dexamethasone for control of growth in infantile parotid hemangiomas. Study design We reviewed and analyzed the data of 31 cases undergoing therapy of intralesional injection with small-dosage and low-concentration bleomycin A5 plus dexamethasone between June 2004 and October 2007. Clinical manifestations, image characteristics, and therapeutic outcomes were reviewed. The therapeutic outcomes were evaluated by physical examination, photographs, and Doppler ultrasonography. The follow-up was from 6 months to 3 years after ending treatment. Results Twenty-five patients (80.6%) had a response rate greater than 90% reduction in tumor size. Three patients (9.7%) had a response rate between 75% and 90% reduction in tumor size. Another 3 patients (9.7%) had a response rate between 50% and 75% reduction in size. No patients had less than a 50% response rate. There was no recurrence, allergic reaction, pulmonary fibrosis, fever, or other complication during or after the course of treatment. Conclusions The controlling therapy with small-dosage and low-concentration bleomycin A5 plus dexamethasone can treat the parotid hemangiomas of infants effectively, especially for lesions in the early phase and proliferative phase. Early control and long-term observation are the key aspects of treatment. |
| doi_str_mv | 10.1016/j.tripleo.2009.02.022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67405947</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1079210409001115</els_id><sourcerecordid>67405947</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-45e0c7f74933c691514b7847b5665de343a7f92a014d936dbd406818a7281b83</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhiMEoh_wE0C-wC3L2LGd-AIqVfmQKvVAhbhZjjPpeknsYCe0--_xaiOQuFQayT4874z9TFG8orChQOW73WaObhowbBiA2gDLxZ4Up1SwpqyU-PE036FWJaPAT4qzlHYAICulnhcnVHFBAcRp8f1jbjHurfPkQpBpWBLp8MGMOG9NCh5JHyKxwc8xDCT05C6G-3lLMu58b_zsBiSTiWF2HdniaPydC6NJL4pnvRkSvlzP8-L209Xt5Zfy-ubz18uL69Jy3swlFwi27muuqspKRQXlbd3wuhVSig4rXpm6V8wA5Z2qZNd2HGRDG1OzhrZNdV68PbadYvi1YJr16JLFYTAew5K0rDkIxesMiiNoY0gpYq-n6EYT95qCPvjUO7361AefGlgulnOv1wFLO2L3L7UKzMCbFTDJmqGPxluX_nKM5l9JJTP34chhtvHbYdTJOvQWOxfRzroL7tGnvP-vgx2cd3noT9xj2oUl-qxaU51yQH87LP-we1AAlFJR_QFL2qrD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67405947</pqid></control><display><type>article</type><title>Bleomycin A5 plus dexamethasone for control of growth in infantile parotid hemangiomas</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Yang, Yaowu, DDS, PhD ; Sun, Moyi, DDS, PhD ; Cheng, Xiaobing, DDS, PhD ; Hu, Xiaoguang, DDS ; Zhang, Pu, DDS, PhD ; Ma, Qin, DDS, PhD ; Li, Jianhu, DDS ; Tian, Lei, DDS, PhD ; Lei, Delin, DDS</creator><creatorcontrib>Yang, Yaowu, DDS, PhD ; Sun, Moyi, DDS, PhD ; Cheng, Xiaobing, DDS, PhD ; Hu, Xiaoguang, DDS ; Zhang, Pu, DDS, PhD ; Ma, Qin, DDS, PhD ; Li, Jianhu, DDS ; Tian, Lei, DDS, PhD ; Lei, Delin, DDS</creatorcontrib><description>Objective The purpose of this study was to evaluate the efficacy of bleomycin A5 (pingyangmycin) plus dexamethasone for control of growth in infantile parotid hemangiomas. Study design We reviewed and analyzed the data of 31 cases undergoing therapy of intralesional injection with small-dosage and low-concentration bleomycin A5 plus dexamethasone between June 2004 and October 2007. Clinical manifestations, image characteristics, and therapeutic outcomes were reviewed. The therapeutic outcomes were evaluated by physical examination, photographs, and Doppler ultrasonography. The follow-up was from 6 months to 3 years after ending treatment. Results Twenty-five patients (80.6%) had a response rate greater than 90% reduction in tumor size. Three patients (9.7%) had a response rate between 75% and 90% reduction in tumor size. Another 3 patients (9.7%) had a response rate between 50% and 75% reduction in size. No patients had less than a 50% response rate. There was no recurrence, allergic reaction, pulmonary fibrosis, fever, or other complication during or after the course of treatment. Conclusions The controlling therapy with small-dosage and low-concentration bleomycin A5 plus dexamethasone can treat the parotid hemangiomas of infants effectively, especially for lesions in the early phase and proliferative phase. Early control and long-term observation are the key aspects of treatment.</description><identifier>ISSN: 1079-2104</identifier><identifier>EISSN: 1528-395X</identifier><identifier>DOI: 10.1016/j.tripleo.2009.02.022</identifier><identifier>PMID: 19451005</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Antibiotics, Antineoplastic - administration & dosage ; Antineoplastic Agents, Hormonal - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Bleomycin - administration & dosage ; Bleomycin - analogs & derivatives ; Bones, joints and connective tissue. Antiinflammatory agents ; Contrast Media ; Dentistry ; Dexamethasone - administration & dosage ; Female ; Follow-Up Studies ; Gadolinium DTPA ; Hemangioma - drug therapy ; Humans ; Infant ; Injections, Intralesional ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Otorhinolaryngology. Stomatology ; Parotid Neoplasms - drug therapy ; Pharmacology. Drug treatments ; Photography ; Physical Examination ; Remission Induction ; Surgery ; Treatment Outcome ; Ultrasonography, Doppler</subject><ispartof>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2009-07, Vol.108 (1), p.62-69</ispartof><rights>Mosby, Inc.</rights><rights>2009 Mosby, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-45e0c7f74933c691514b7847b5665de343a7f92a014d936dbd406818a7281b83</citedby><cites>FETCH-LOGICAL-c448t-45e0c7f74933c691514b7847b5665de343a7f92a014d936dbd406818a7281b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tripleo.2009.02.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21691696$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19451005$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Yaowu, DDS, PhD</creatorcontrib><creatorcontrib>Sun, Moyi, DDS, PhD</creatorcontrib><creatorcontrib>Cheng, Xiaobing, DDS, PhD</creatorcontrib><creatorcontrib>Hu, Xiaoguang, DDS</creatorcontrib><creatorcontrib>Zhang, Pu, DDS, PhD</creatorcontrib><creatorcontrib>Ma, Qin, DDS, PhD</creatorcontrib><creatorcontrib>Li, Jianhu, DDS</creatorcontrib><creatorcontrib>Tian, Lei, DDS, PhD</creatorcontrib><creatorcontrib>Lei, Delin, DDS</creatorcontrib><title>Bleomycin A5 plus dexamethasone for control of growth in infantile parotid hemangiomas</title><title>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</title><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><description>Objective The purpose of this study was to evaluate the efficacy of bleomycin A5 (pingyangmycin) plus dexamethasone for control of growth in infantile parotid hemangiomas. Study design We reviewed and analyzed the data of 31 cases undergoing therapy of intralesional injection with small-dosage and low-concentration bleomycin A5 plus dexamethasone between June 2004 and October 2007. Clinical manifestations, image characteristics, and therapeutic outcomes were reviewed. The therapeutic outcomes were evaluated by physical examination, photographs, and Doppler ultrasonography. The follow-up was from 6 months to 3 years after ending treatment. Results Twenty-five patients (80.6%) had a response rate greater than 90% reduction in tumor size. Three patients (9.7%) had a response rate between 75% and 90% reduction in tumor size. Another 3 patients (9.7%) had a response rate between 50% and 75% reduction in size. No patients had less than a 50% response rate. There was no recurrence, allergic reaction, pulmonary fibrosis, fever, or other complication during or after the course of treatment. Conclusions The controlling therapy with small-dosage and low-concentration bleomycin A5 plus dexamethasone can treat the parotid hemangiomas of infants effectively, especially for lesions in the early phase and proliferative phase. Early control and long-term observation are the key aspects of treatment.</description><subject>Antibiotics, Antineoplastic - administration & dosage</subject><subject>Antineoplastic Agents, Hormonal - administration & dosage</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bleomycin - administration & dosage</subject><subject>Bleomycin - analogs & derivatives</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Contrast Media</subject><subject>Dentistry</subject><subject>Dexamethasone - administration & dosage</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gadolinium DTPA</subject><subject>Hemangioma - drug therapy</subject><subject>Humans</subject><subject>Infant</subject><subject>Injections, Intralesional</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Parotid Neoplasms - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Photography</subject><subject>Physical Examination</subject><subject>Remission Induction</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Ultrasonography, Doppler</subject><issn>1079-2104</issn><issn>1528-395X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEoh_wE0C-wC3L2LGd-AIqVfmQKvVAhbhZjjPpeknsYCe0--_xaiOQuFQayT4874z9TFG8orChQOW73WaObhowbBiA2gDLxZ4Up1SwpqyU-PE036FWJaPAT4qzlHYAICulnhcnVHFBAcRp8f1jbjHurfPkQpBpWBLp8MGMOG9NCh5JHyKxwc8xDCT05C6G-3lLMu58b_zsBiSTiWF2HdniaPydC6NJL4pnvRkSvlzP8-L209Xt5Zfy-ubz18uL69Jy3swlFwi27muuqspKRQXlbd3wuhVSig4rXpm6V8wA5Z2qZNd2HGRDG1OzhrZNdV68PbadYvi1YJr16JLFYTAew5K0rDkIxesMiiNoY0gpYq-n6EYT95qCPvjUO7361AefGlgulnOv1wFLO2L3L7UKzMCbFTDJmqGPxluX_nKM5l9JJTP34chhtvHbYdTJOvQWOxfRzroL7tGnvP-vgx2cd3noT9xj2oUl-qxaU51yQH87LP-we1AAlFJR_QFL2qrD</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Yang, Yaowu, DDS, PhD</creator><creator>Sun, Moyi, DDS, PhD</creator><creator>Cheng, Xiaobing, DDS, PhD</creator><creator>Hu, Xiaoguang, DDS</creator><creator>Zhang, Pu, DDS, PhD</creator><creator>Ma, Qin, DDS, PhD</creator><creator>Li, Jianhu, DDS</creator><creator>Tian, Lei, DDS, PhD</creator><creator>Lei, Delin, DDS</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Bleomycin A5 plus dexamethasone for control of growth in infantile parotid hemangiomas</title><author>Yang, Yaowu, DDS, PhD ; Sun, Moyi, DDS, PhD ; Cheng, Xiaobing, DDS, PhD ; Hu, Xiaoguang, DDS ; Zhang, Pu, DDS, PhD ; Ma, Qin, DDS, PhD ; Li, Jianhu, DDS ; Tian, Lei, DDS, PhD ; Lei, Delin, DDS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-45e0c7f74933c691514b7847b5665de343a7f92a014d936dbd406818a7281b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Antibiotics, Antineoplastic - administration & dosage</topic><topic>Antineoplastic Agents, Hormonal - administration & dosage</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Bleomycin - administration & dosage</topic><topic>Bleomycin - analogs & derivatives</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Contrast Media</topic><topic>Dentistry</topic><topic>Dexamethasone - administration & dosage</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gadolinium DTPA</topic><topic>Hemangioma - drug therapy</topic><topic>Humans</topic><topic>Infant</topic><topic>Injections, Intralesional</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Parotid Neoplasms - drug therapy</topic><topic>Pharmacology. Drug treatments</topic><topic>Photography</topic><topic>Physical Examination</topic><topic>Remission Induction</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Ultrasonography, Doppler</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Yaowu, DDS, PhD</creatorcontrib><creatorcontrib>Sun, Moyi, DDS, PhD</creatorcontrib><creatorcontrib>Cheng, Xiaobing, DDS, PhD</creatorcontrib><creatorcontrib>Hu, Xiaoguang, DDS</creatorcontrib><creatorcontrib>Zhang, Pu, DDS, PhD</creatorcontrib><creatorcontrib>Ma, Qin, DDS, PhD</creatorcontrib><creatorcontrib>Li, Jianhu, DDS</creatorcontrib><creatorcontrib>Tian, Lei, DDS, PhD</creatorcontrib><creatorcontrib>Lei, Delin, DDS</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Yaowu, DDS, PhD</au><au>Sun, Moyi, DDS, PhD</au><au>Cheng, Xiaobing, DDS, PhD</au><au>Hu, Xiaoguang, DDS</au><au>Zhang, Pu, DDS, PhD</au><au>Ma, Qin, DDS, PhD</au><au>Li, Jianhu, DDS</au><au>Tian, Lei, DDS, PhD</au><au>Lei, Delin, DDS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bleomycin A5 plus dexamethasone for control of growth in infantile parotid hemangiomas</atitle><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>108</volume><issue>1</issue><spage>62</spage><epage>69</epage><pages>62-69</pages><issn>1079-2104</issn><eissn>1528-395X</eissn><abstract>Objective The purpose of this study was to evaluate the efficacy of bleomycin A5 (pingyangmycin) plus dexamethasone for control of growth in infantile parotid hemangiomas. Study design We reviewed and analyzed the data of 31 cases undergoing therapy of intralesional injection with small-dosage and low-concentration bleomycin A5 plus dexamethasone between June 2004 and October 2007. Clinical manifestations, image characteristics, and therapeutic outcomes were reviewed. The therapeutic outcomes were evaluated by physical examination, photographs, and Doppler ultrasonography. The follow-up was from 6 months to 3 years after ending treatment. Results Twenty-five patients (80.6%) had a response rate greater than 90% reduction in tumor size. Three patients (9.7%) had a response rate between 75% and 90% reduction in tumor size. Another 3 patients (9.7%) had a response rate between 50% and 75% reduction in size. No patients had less than a 50% response rate. There was no recurrence, allergic reaction, pulmonary fibrosis, fever, or other complication during or after the course of treatment. Conclusions The controlling therapy with small-dosage and low-concentration bleomycin A5 plus dexamethasone can treat the parotid hemangiomas of infants effectively, especially for lesions in the early phase and proliferative phase. Early control and long-term observation are the key aspects of treatment.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>19451005</pmid><doi>10.1016/j.tripleo.2009.02.022</doi><tpages>8</tpages></addata></record> |
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| ispartof | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2009-07, Vol.108 (1), p.62-69 |
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| subjects | Antibiotics, Antineoplastic - administration & dosage Antineoplastic Agents, Hormonal - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Bleomycin - administration & dosage Bleomycin - analogs & derivatives Bones, joints and connective tissue. Antiinflammatory agents Contrast Media Dentistry Dexamethasone - administration & dosage Female Follow-Up Studies Gadolinium DTPA Hemangioma - drug therapy Humans Infant Injections, Intralesional Magnetic Resonance Imaging Male Medical sciences Otorhinolaryngology. Stomatology Parotid Neoplasms - drug therapy Pharmacology. Drug treatments Photography Physical Examination Remission Induction Surgery Treatment Outcome Ultrasonography, Doppler |
| title | Bleomycin A5 plus dexamethasone for control of growth in infantile parotid hemangiomas |
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