Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function

Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic BH3-only proteins via interaction of its BH3 domain with a groove on the Bcl-2-like proteins. These interactions have been considered promiscuous, but our analysis of the affinity of eight BH3 peptides for fi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cell 2005-02, Vol.17 (3), p.393-403
Hauptverfasser:	Chen, Lin, Willis, Simon N., Wei, Andrew, Smith, Brian J., Fletcher, Jamie I., Hinds, Mark G., Colman, Peter M., Day, Catherine L., Adams, Jerry M., Huang, David C.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Apoptosis - physiology Apoptosis Regulatory Proteins Bcl-2-Like Protein 11 bcl-X Protein Binding, Competitive Biosensing Techniques Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Cell Survival - physiology Genetic Complementation Test Humans In Vitro Techniques Ligands Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Mice Models, Biological Models, Molecular Molecular Sequence Data Myeloid Cell Leukemia Sequence 1 Protein Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Protein Structure, Tertiary Proteins - chemistry Proteins - genetics Proteins - metabolism Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - chemistry Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Homology, Amino Acid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!