SHIP1 Is a Repressor of Mast Cell Hyperplasia, Cytokine Production, and Allergic Inflammation In Vivo

SHIP1 inhibits immune receptor signaling through hydrolysis of the PI3K product phosphatidylinositol 3,4,5-trisphosphate, forming phosphatidylinositol 3,4-bisphosphate. In mast cells, SHIP1 represses FcepsilonRI- and cytokine-mediated activation in vitro, but little is known regarding the function o...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-07, Vol.183 (1), p.228-236
Hauptverfasser:	Haddon, D. James, Antignano, Frann, Hughes, Michael R, Blanchet, Marie-Renee, Zbytnuik, Lori, Krystal, Gerald, McNagny, Kelly M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphylaxis - enzymology Anaphylaxis - genetics Anaphylaxis - pathology Animals Cells, Cultured Cytokines - antagonists & inhibitors Cytokines - biosynthesis Cytokines - physiology Female Hyperplasia - enzymology Hyperplasia - genetics Hyperplasia - prevention & control Hypersensitivity - enzymology Hypersensitivity - genetics Hypersensitivity - pathology Hypersensitivity - prevention & control Inflammation Mediators - physiology Inositol Polyphosphate 5-Phosphatases Mast Cells - enzymology Mast Cells - pathology Mice Mice, Congenic Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases Phosphoric Monoester Hydrolases - deficiency Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - physiology
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