Habituation-induced neural plasticity in the hippocampus and prefrontal cortex mediated by MMP-3
Head-shake response (HSR) habituation was presently used to investigate the phenomena of spontaneous recovery and neural plasticity. Independent groups of rats were presented with five consecutive habituation sessions separated by inter-session intervals (ISIs) of 2, 24 or 72h. At the conclusion of...
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| creator | Wright, John W. Meighan, Peter C. Brown, Travis E. Wiediger, Roberta V. Sorg, Barbara A. Harding, Joseph W. |
| description | Head-shake response (HSR) habituation was presently used to investigate the phenomena of spontaneous recovery and neural plasticity. Independent groups of rats were presented with five consecutive habituation sessions separated by inter-session intervals (ISIs) of 2, 24 or 72h. At the conclusion of testing hippocampus and prefrontal cortex tissue samples were collected for determination of matrix metalloproteinase-3 (MMP-3:stromelysin-1) expression as a marker of neural plasticity. The results indicated that by the fifth session the 2h ISI group showed no spontaneous recovery, the 72h ISI group revealed nearly complete spontaneous recovery; while the 24h ISI group showed intermediate recovery. MMP-3 expression in the hippocampus and prefrontal cortex was elevated in the 2 and 72h ISI groups, but not in the 24h group. A second experiment utilized 7-day osmotic pumps to intracerebroventricularly infuse an MMP-3 inhibitor for 6 days. The animals were then tested on the seventh day using the 2h ISI protocol. Delivery of the MMP-3 inhibitor facilitated spontaneous recovery, thus compromising the animal's ability to appropriately habituate. This effect was accompanied by a significant inhibition of hippocampus and prefrontal cortex MMP-3 expression. These results suggest that elevations in hippocampus and prefrontal cortex MMP-3 expression contribute to this simplest form of learning and may be a mechanism underlying spontaneous recovery. |
| doi_str_mv | 10.1016/j.bbr.2009.04.014 |
| format | Article |
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Independent groups of rats were presented with five consecutive habituation sessions separated by inter-session intervals (ISIs) of 2, 24 or 72h. At the conclusion of testing hippocampus and prefrontal cortex tissue samples were collected for determination of matrix metalloproteinase-3 (MMP-3:stromelysin-1) expression as a marker of neural plasticity. The results indicated that by the fifth session the 2h ISI group showed no spontaneous recovery, the 72h ISI group revealed nearly complete spontaneous recovery; while the 24h ISI group showed intermediate recovery. MMP-3 expression in the hippocampus and prefrontal cortex was elevated in the 2 and 72h ISI groups, but not in the 24h group. A second experiment utilized 7-day osmotic pumps to intracerebroventricularly infuse an MMP-3 inhibitor for 6 days. The animals were then tested on the seventh day using the 2h ISI protocol. Delivery of the MMP-3 inhibitor facilitated spontaneous recovery, thus compromising the animal's ability to appropriately habituate. This effect was accompanied by a significant inhibition of hippocampus and prefrontal cortex MMP-3 expression. These results suggest that elevations in hippocampus and prefrontal cortex MMP-3 expression contribute to this simplest form of learning and may be a mechanism underlying spontaneous recovery.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2009.04.014</identifier><identifier>PMID: 19389428</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Analysis of Variance ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Blotting, Western ; Enzyme Inhibitors - pharmacology ; Fundamental and applied biological sciences. 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Independent groups of rats were presented with five consecutive habituation sessions separated by inter-session intervals (ISIs) of 2, 24 or 72h. At the conclusion of testing hippocampus and prefrontal cortex tissue samples were collected for determination of matrix metalloproteinase-3 (MMP-3:stromelysin-1) expression as a marker of neural plasticity. The results indicated that by the fifth session the 2h ISI group showed no spontaneous recovery, the 72h ISI group revealed nearly complete spontaneous recovery; while the 24h ISI group showed intermediate recovery. MMP-3 expression in the hippocampus and prefrontal cortex was elevated in the 2 and 72h ISI groups, but not in the 24h group. A second experiment utilized 7-day osmotic pumps to intracerebroventricularly infuse an MMP-3 inhibitor for 6 days. The animals were then tested on the seventh day using the 2h ISI protocol. Delivery of the MMP-3 inhibitor facilitated spontaneous recovery, thus compromising the animal's ability to appropriately habituate. This effect was accompanied by a significant inhibition of hippocampus and prefrontal cortex MMP-3 expression. These results suggest that elevations in hippocampus and prefrontal cortex MMP-3 expression contribute to this simplest form of learning and may be a mechanism underlying spontaneous recovery.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Habituation</subject><subject>Habituation, Psychophysiologic - drug effects</subject><subject>Habituation, Psychophysiologic - physiology</subject><subject>Head</subject><subject>Head-shake response</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>Learning - drug effects</subject><subject>Learning - physiology</subject><subject>Male</subject><subject>Matrix Metalloproteinase 3 - metabolism</subject><subject>Matrix Metalloproteinase Inhibitors</subject><subject>Matrix metalloproteinases</subject><subject>Matrix Metalloproteinases, Secreted - antagonists & inhibitors</subject><subject>MMP-3</subject><subject>MMP-3 inhibitor</subject><subject>Neural plasticity</subject><subject>Neuronal Plasticity - drug effects</subject><subject>Neuronal Plasticity - physiology</subject><subject>Nonassociative learning</subject><subject>Prefrontal Cortex - drug effects</subject><subject>Prefrontal Cortex - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Spontaneous recovery</subject><subject>Time Factors</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EotvCA3BBvsAtwXbsOBEnVAFFakUP5WzsyUT1KusE26m6b49Xuyo3eprLN__MfEPIO85qznj7aVs7F2vBWF8zWTMuX5AN77SotJL9S7IpTFvJRnRn5DylLWNMMsVfkzPeN10vRbchv6-s83m12c-h8mFYAQcacI12ostkU_bg8576QPM90nu_LDPY3bImasNAl4hjnEMuMMwx4yPd4eBtLhluT29ubqvmDXk12inh21O9IL--fb27vKquf37_cfnlugLJRa4UNK0elZYolLadaplC3XdKat0o3QAwrbkamOscjCCB8xbdAGrQDnrJRHNBPh5zlzj_WTFls_MJcJpswHlNptWy6Oi7Z0HBWqV7cUjkRxDinFK51CzR72zcG87Mwb_ZmuLfHPwbJk3xX3ren8JXV1T86zgJL8CHE2AT2GmMNoBPT5zgZU-lDsM_Hzkszh48RpPAYyjf8REhm2H2_1njL9P5onI</recordid><startdate>20091012</startdate><enddate>20091012</enddate><creator>Wright, John W.</creator><creator>Meighan, Peter C.</creator><creator>Brown, Travis E.</creator><creator>Wiediger, Roberta V.</creator><creator>Sorg, Barbara A.</creator><creator>Harding, Joseph W.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20091012</creationdate><title>Habituation-induced neural plasticity in the hippocampus and prefrontal cortex mediated by MMP-3</title><author>Wright, John W. ; Meighan, Peter C. ; Brown, Travis E. ; Wiediger, Roberta V. ; Sorg, Barbara A. ; Harding, Joseph W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-5c367f574e257a85605e79854773573cc07715d0b8bcfc4c116ebdc5d7bc94023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Habituation</topic><topic>Habituation, Psychophysiologic - drug effects</topic><topic>Habituation, Psychophysiologic - physiology</topic><topic>Head</topic><topic>Head-shake response</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiology</topic><topic>Learning - drug effects</topic><topic>Learning - physiology</topic><topic>Male</topic><topic>Matrix Metalloproteinase 3 - metabolism</topic><topic>Matrix Metalloproteinase Inhibitors</topic><topic>Matrix metalloproteinases</topic><topic>Matrix Metalloproteinases, Secreted - antagonists & inhibitors</topic><topic>MMP-3</topic><topic>MMP-3 inhibitor</topic><topic>Neural plasticity</topic><topic>Neuronal Plasticity - drug effects</topic><topic>Neuronal Plasticity - physiology</topic><topic>Nonassociative learning</topic><topic>Prefrontal Cortex - drug effects</topic><topic>Prefrontal Cortex - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Spontaneous recovery</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wright, John W.</creatorcontrib><creatorcontrib>Meighan, Peter C.</creatorcontrib><creatorcontrib>Brown, Travis E.</creatorcontrib><creatorcontrib>Wiediger, Roberta V.</creatorcontrib><creatorcontrib>Sorg, Barbara A.</creatorcontrib><creatorcontrib>Harding, Joseph W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wright, John W.</au><au>Meighan, Peter C.</au><au>Brown, Travis E.</au><au>Wiediger, Roberta V.</au><au>Sorg, Barbara A.</au><au>Harding, Joseph W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Habituation-induced neural plasticity in the hippocampus and prefrontal cortex mediated by MMP-3</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2009-10-12</date><risdate>2009</risdate><volume>203</volume><issue>1</issue><spage>27</spage><epage>34</epage><pages>27-34</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>Head-shake response (HSR) habituation was presently used to investigate the phenomena of spontaneous recovery and neural plasticity. Independent groups of rats were presented with five consecutive habituation sessions separated by inter-session intervals (ISIs) of 2, 24 or 72h. At the conclusion of testing hippocampus and prefrontal cortex tissue samples were collected for determination of matrix metalloproteinase-3 (MMP-3:stromelysin-1) expression as a marker of neural plasticity. The results indicated that by the fifth session the 2h ISI group showed no spontaneous recovery, the 72h ISI group revealed nearly complete spontaneous recovery; while the 24h ISI group showed intermediate recovery. MMP-3 expression in the hippocampus and prefrontal cortex was elevated in the 2 and 72h ISI groups, but not in the 24h group. A second experiment utilized 7-day osmotic pumps to intracerebroventricularly infuse an MMP-3 inhibitor for 6 days. The animals were then tested on the seventh day using the 2h ISI protocol. Delivery of the MMP-3 inhibitor facilitated spontaneous recovery, thus compromising the animal's ability to appropriately habituate. This effect was accompanied by a significant inhibition of hippocampus and prefrontal cortex MMP-3 expression. These results suggest that elevations in hippocampus and prefrontal cortex MMP-3 expression contribute to this simplest form of learning and may be a mechanism underlying spontaneous recovery.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>19389428</pmid><doi>10.1016/j.bbr.2009.04.014</doi><tpages>8</tpages></addata></record> |
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| subjects | Analysis of Variance Animals Behavioral psychophysiology Biological and medical sciences Blotting, Western Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Habituation Habituation, Psychophysiologic - drug effects Habituation, Psychophysiologic - physiology Head Head-shake response Hippocampus - drug effects Hippocampus - physiology Learning - drug effects Learning - physiology Male Matrix Metalloproteinase 3 - metabolism Matrix Metalloproteinase Inhibitors Matrix metalloproteinases Matrix Metalloproteinases, Secreted - antagonists & inhibitors MMP-3 MMP-3 inhibitor Neural plasticity Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Nonassociative learning Prefrontal Cortex - drug effects Prefrontal Cortex - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Random Allocation Rats Rats, Sprague-Dawley Spontaneous recovery Time Factors |
| title | Habituation-induced neural plasticity in the hippocampus and prefrontal cortex mediated by MMP-3 |
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