Synthesis and Biological Testing of Purine Derivatives as Potential ATP-Competitive Kinase Inhibitors

On the basis of ATP adenine, a series of adenine and purine derivatives was prepared and tested for their ability to inhibit a spectrum of disease-related kinases. There has been scant research investigating the potential of cosubstrate derived kinase inhibitors for other kinases than CDKs. Our inhi...

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Veröffentlicht in:	Journal of medicinal chemistry 2005-02, Vol.48 (3), p.710-722
Hauptverfasser:	Laufer, Stefan A, Domeyer, David M, Scior, Thomas R. F, Albrecht, Wolfgang, Hauser, Dominik R. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - chemistry Adenosine Triphosphate - metabolism Binding Sites Binding, Competitive Models, Molecular p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - chemistry Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinases - chemistry Protein Kinases - metabolism Purines - chemical synthesis Purines - chemistry Structure-Activity Relationship
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