Monocyte chemoattractant protein-1–induced angiogenesis is mediated by vascular endothelial growth factor-A

Monocyte chemoattractant protein-1 (MCP-1) has been recognized as an angiogenic chemokine. In the present study, we investigated the detailed mechanism by which MCP-1 induces angiogenesis. We found that MCP-1 up-regulated hypoxia-inducible factor 1α (HIF-1α) gene expression in human aortic endotheli...

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Veröffentlicht in:	Blood 2005-02, Vol.105 (4), p.1405-1407
Hauptverfasser:	Hong, Kyung Hee, Ryu, Jewon, Han, Ki Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Angiogenesis Inducing Agents - administration & dosage Animals Aorta, Abdominal - physiology Aorta, Thoracic - physiology Biological and medical sciences Cells, Cultured Chemokine CCL2 - administration & dosage Chemokine CCL2 - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Endothelium, Vascular - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Hypoxia-Inducible Factor 1, alpha Subunit Immunobiology Lymphokines, interleukins ( function, expression) Male Neovascularization, Physiologic - physiology Rats Rats, Sprague-Dawley Regulatory factors and their cellular receptors RNA, Messenger - biosynthesis Transcription Factors - biosynthesis Transcription Factors - genetics Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - physiology
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