Adenovirus-mediated overexpression of human tissue plasminogen activator prevents peritoneal adhesion formation/reformation in rats

Background Tissue-plasminogen activator (tPA) demonstrated beneficial effects on peritoneal adhesion formation; however, its short half-life limits its continual fibrinolytic effect. Therefore, we delivered adenovirus encoding tPA to prevent adhesions. Methods Rats were subjected to peritoneal injur...

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Veröffentlicht in:	Surgery 2009-07, Vol.146 (1), p.12-17
Hauptverfasser:	Atta, Hussein M., PhD, Al-Hendy, Ayman, PhD, El-Rehany, Mahmoud A., PhD, Dewerchin, Mieke, PhD, Abdel Raheim, Salama R., PhD, Ghany, Hend Abdel, PhD, Fouad, Rasha, MS
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Biological and medical sciences Disease Models, Animal Fibrinolysis - physiology General aspects Humans Injections, Intraperitoneal Male Medical sciences Peritoneal Diseases - metabolism Peritoneal Diseases - prevention & control Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Rats Rats, Wistar Severity of Illness Index Surgery Tissue Adhesions - metabolism Tissue Adhesions - prevention & control Tissue Plasminogen Activator - administration & dosage Tissue Plasminogen Activator - genetics Tissue Plasminogen Activator - metabolism Transfection
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