Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release

The use of chemical modifiers as radiosensitizers in combination with low-dose irradiation may increase the therapeutic effect on cancer by overcoming a high apoptotic threshold. Here, we showed that phytosphingosine treatment in combination with γ-radiation enhanced apoptotic cell death of radiatio...

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Veröffentlicht in:	Blood 2005-02, Vol.105 (4), p.1724-1733
Hauptverfasser:	Park, Moon-Taek, Kim, Min-Jung, Kang, Young-Hee, Choi, Soon-Young, Lee, Jae-Hoon, Choi, Jung-A, Kang, Chang-Mo, Cho, Chul-Koo, Kang, Seongman, Bae, Sangwoo, Lee, Yun-Sil, Chung, Hee Yong, Lee, Su-Jae
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Active Transport, Cell Nucleus - radiation effects Antineoplastic agents Apoptosis - drug effects Apoptosis - radiation effects Apoptosis Inducing Factor bcl-2-Associated X Protein Biological and medical sciences Cell Nucleus - drug effects Cell Nucleus - metabolism Cell Nucleus - radiation effects Clone Cells Combined Modality Therapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Enzyme Activation - drug effects Enzyme Activation - radiation effects Flavoproteins - metabolism Gamma Rays Humans Intracellular Membranes - drug effects Intracellular Membranes - metabolism Intracellular Membranes - radiation effects Jurkat Cells Medical sciences Membrane Potentials - drug effects Membrane Potentials - radiation effects Membrane Proteins - metabolism Mitochondria - drug effects Mitochondria - metabolism Mitochondria - radiation effects Pharmacology. Drug treatments Poly(ADP-ribose) Polymerases - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Radiation Tolerance Reactive Oxygen Species - pharmacology Sphingosine - analogs & derivatives Sphingosine - pharmacology
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