Dronedarone administration prevents body weight gain and increases tolerance of the heart to ischemic stress: a possible involvement of thyroid hormone receptor alpha1

Hypothyroid heart displays a phenotype of cardioprotection against ischemia and this study investigated whether administration of dronedarone, an amiodarone-like compound that has been shown to preferentially antagonize thyroid hormone binding to thyroid hormone receptor alpha1 (TRalpha1), results i...

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Veröffentlicht in:	Thyroid (New York, N.Y.) N.Y.), 2005-01, Vol.15 (1), p.16-23
Hauptverfasser:	Pantos, Constantinos, Mourouzis, Iordanis, Malliopoulou, Vassiliki, Paizis, Ioannis, Tzeis, Stylianos, Moraitis, Panagiotis, Sfakianoudis, Konstantinos, Varonos, Dennis D, Cokkinos, Dennis V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Amiodarone - analogs & derivatives Amiodarone - pharmacology Animals Calcium-Transporting ATPases - metabolism Eating - drug effects Glycogen - metabolism Heart - drug effects Heart - physiopathology Heart Rate - drug effects Hypothyroidism - metabolism Hypothyroidism - physiopathology In Vitro Techniques Isomerism L-Lactate Dehydrogenase - metabolism Male Myocardial Contraction Myocardial Ischemia - metabolism Myocardial Ischemia - physiopathology Myocardial Reperfusion Injury - physiopathology Myocardium - metabolism Myosins - metabolism Rats Rats, Wistar Sarcoplasmic Reticulum - enzymology Thyroid Hormone Receptors alpha - metabolism Thyroid Hormones - metabolism Weight Gain - drug effects
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