Focal adhesion kinase: in command and control of cell motility

A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion kinase (FAK) is a crucial signalling component that is activated by numerous stimuli and functions as a biosensor or integrator to...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2005-01, Vol.6 (1), p.56-68
Hauptverfasser:	Schlaepfer, David D, Mitra, Satyajit K, Hanson, Daniel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals Biosensors Cell adhesion & migration Cell Membrane - physiology Cell Movement - physiology Cytoskeletal Proteins - physiology Cytoskeleton Cytoskeleton - physiology Extracellular matrix Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases Growth factors Humans Intercellular Junctions - physiology Kinases Membranes Motility Paxillin Phosphoproteins - physiology Phosphorylation Polymerization Protein Structure, Tertiary Protein-Tyrosine Kinases - physiology Proteins Proteins - physiology Retinoblastoma-Like Protein p130
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Beschreibung
Zusammenfassung:	A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion kinase (FAK) is a crucial signalling component that is activated by numerous stimuli and functions as a biosensor or integrator to control cell motility. Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement.
ISSN:	1471-0072 1471-0080
DOI:	10.1038/nrm1549