Development and Duration of Human Papillomavirus Lesions, after Initial Infection
BackgroundTo determine the potential value of human papillomavirus (HPV) vaccines, information concerning the incidence and duration of clinically important lesions is needed MethodsA total of 603 female university students were followed for a mean duration of 38.8 months. Triannual gynecologic exam...
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| Veröffentlicht in: | The Journal of infectious diseases 2005-03, Vol.191 (5), p.731-738 |
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| container_title | The Journal of infectious diseases |
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| creator | Winer, Rachel L. Kiviat, Nancy B. Hughes, James P. Adam, Diane E. Lee, Shu-Kuang Kuypers, Jane M. Koutsky, Laura A. |
| description | BackgroundTo determine the potential value of human papillomavirus (HPV) vaccines, information concerning the incidence and duration of clinically important lesions is needed MethodsA total of 603 female university students were followed for a mean duration of 38.8 months. Triannual gynecologic examinations included cervical and vulvovaginal specimen collection for Pap and HPV DNA testing. Women with cytologic evidence of a high-grade squamous intraepithelial lesion (SIL) were referred for colposcopically directed biopsy ResultsAmong women with incident HPV infection, the 36-month cumulative incidence of cervical SILs found by cytologic testing (47.2%; 95% confidence interval [CI], 38.9%–56.4%) was higher than that of vaginal SILs (28.8%; 95% CI, 21.3%–38.2%). The median time to clearance of cervical and vaginal SILs was 5.5 and 4.7 months, respectively. Among women with incident HPV-16 or HPV-18 infection, the 36-month cumulative incidence of cervical intraepithelial neoplasia (CIN) grade 2 was 20.0% (95% CI, 10.8%–35.1%), and that of CIN grade 3 was 6.7% (95% CI, 2.5%–17.0%). The 36-month cumulative incidence of clinically ascertained genital warts among women with incident HPV-6 or HPV-11 infection was 64.2% (95% CI, 50.7%–77.4%) ConclusionsIntraepithelial lesions are common early events among women with incident HPV infection, and the interval between incident HPV-16 or HPV-18 infection and biopsy-confirmed CIN grade 2–3 appears to be relatively short |
| doi_str_mv | 10.1086/427557 |
| format | Article |
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Triannual gynecologic examinations included cervical and vulvovaginal specimen collection for Pap and HPV DNA testing. Women with cytologic evidence of a high-grade squamous intraepithelial lesion (SIL) were referred for colposcopically directed biopsy ResultsAmong women with incident HPV infection, the 36-month cumulative incidence of cervical SILs found by cytologic testing (47.2%; 95% confidence interval [CI], 38.9%–56.4%) was higher than that of vaginal SILs (28.8%; 95% CI, 21.3%–38.2%). The median time to clearance of cervical and vaginal SILs was 5.5 and 4.7 months, respectively. Among women with incident HPV-16 or HPV-18 infection, the 36-month cumulative incidence of cervical intraepithelial neoplasia (CIN) grade 2 was 20.0% (95% CI, 10.8%–35.1%), and that of CIN grade 3 was 6.7% (95% CI, 2.5%–17.0%). The 36-month cumulative incidence of clinically ascertained genital warts among women with incident HPV-6 or HPV-11 infection was 64.2% (95% CI, 50.7%–77.4%) ConclusionsIntraepithelial lesions are common early events among women with incident HPV infection, and the interval between incident HPV-16 or HPV-18 infection and biopsy-confirmed CIN grade 2–3 appears to be relatively short</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/427557</identifier><identifier>PMID: 15688287</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Biopsies ; Cervical intraepithelial neoplasia ; Cervical Intraepithelial Neoplasia - virology ; Cervix Uteri - pathology ; Cervix Uteri - virology ; Condylomata acuminata ; Condylomata Acuminata - pathology ; Condylomata Acuminata - physiopathology ; Female ; Fundamental and applied biological sciences. Psychology ; Human papillomavirus ; Human papillomavirus 11 ; Human papillomavirus 16 ; Human papillomavirus 18 ; Human papillomavirus 6 ; Humans ; Infections ; Infectious diseases ; Lesions ; Longitudinal Studies ; Medical sciences ; Microbiology ; Miscellaneous ; Papillomaviridae - pathogenicity ; Papillomavirus Infections - pathology ; Papillomavirus Infections - physiopathology ; Time Factors ; Uterine Cervical Neoplasms - virology ; Virology ; Viruses ; Women</subject><ispartof>The Journal of infectious diseases, 2005-03, Vol.191 (5), p.731-738</ispartof><rights>Copyright 2005 Infectious Diseases Society of America</rights><rights>2005 by the Infectious Diseases Society of America 2005</rights><rights>2005 INIST-CNRS</rights><rights>Copyright University of Chicago Press Mar 1, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-e52766889fa536e72b653504fc5db3b72e5b4aaea7d4c02b243f9efb8021b3c83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30077554$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30077554$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16698397$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15688287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Winer, Rachel L.</creatorcontrib><creatorcontrib>Kiviat, Nancy B.</creatorcontrib><creatorcontrib>Hughes, James P.</creatorcontrib><creatorcontrib>Adam, Diane E.</creatorcontrib><creatorcontrib>Lee, Shu-Kuang</creatorcontrib><creatorcontrib>Kuypers, Jane M.</creatorcontrib><creatorcontrib>Koutsky, Laura A.</creatorcontrib><title>Development and Duration of Human Papillomavirus Lesions, after Initial Infection</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>BackgroundTo determine the potential value of human papillomavirus (HPV) vaccines, information concerning the incidence and duration of clinically important lesions is needed MethodsA total of 603 female university students were followed for a mean duration of 38.8 months. Triannual gynecologic examinations included cervical and vulvovaginal specimen collection for Pap and HPV DNA testing. Women with cytologic evidence of a high-grade squamous intraepithelial lesion (SIL) were referred for colposcopically directed biopsy ResultsAmong women with incident HPV infection, the 36-month cumulative incidence of cervical SILs found by cytologic testing (47.2%; 95% confidence interval [CI], 38.9%–56.4%) was higher than that of vaginal SILs (28.8%; 95% CI, 21.3%–38.2%). The median time to clearance of cervical and vaginal SILs was 5.5 and 4.7 months, respectively. Among women with incident HPV-16 or HPV-18 infection, the 36-month cumulative incidence of cervical intraepithelial neoplasia (CIN) grade 2 was 20.0% (95% CI, 10.8%–35.1%), and that of CIN grade 3 was 6.7% (95% CI, 2.5%–17.0%). The 36-month cumulative incidence of clinically ascertained genital warts among women with incident HPV-6 or HPV-11 infection was 64.2% (95% CI, 50.7%–77.4%) ConclusionsIntraepithelial lesions are common early events among women with incident HPV infection, and the interval between incident HPV-16 or HPV-18 infection and biopsy-confirmed CIN grade 2–3 appears to be relatively short</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsies</subject><subject>Cervical intraepithelial neoplasia</subject><subject>Cervical Intraepithelial Neoplasia - virology</subject><subject>Cervix Uteri - pathology</subject><subject>Cervix Uteri - virology</subject><subject>Condylomata acuminata</subject><subject>Condylomata Acuminata - pathology</subject><subject>Condylomata Acuminata - physiopathology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human papillomavirus</subject><subject>Human papillomavirus 11</subject><subject>Human papillomavirus 16</subject><subject>Human papillomavirus 18</subject><subject>Human papillomavirus 6</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Lesions</subject><subject>Longitudinal Studies</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Papillomaviridae - pathogenicity</subject><subject>Papillomavirus Infections - pathology</subject><subject>Papillomavirus Infections - physiopathology</subject><subject>Time Factors</subject><subject>Uterine Cervical Neoplasms - virology</subject><subject>Virology</subject><subject>Viruses</subject><subject>Women</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVuL1EAQhRtR3NlV_4ESBX0y2pf0JY8yszrLDqh4QXxpOj3V0GOSjt3Jov_eDhl2QBCf6uF8depUFUKPCH5FsBKvKyo5l3fQinAmSyEIu4tWGFNaElXXZ-g8pQPGuGJC3kdnhAulqJIr9HEDN9CGoYN-LEy_LzZTNKMPfRFcsZ060xcfzODbNnTmxscpFTtIWU4vC-NGiMVV70dv2lwd2LnxAbrnTJvg4bFeoC9vLz-vt-Xu_bur9ZtdaXlVjyVwKkVOUTvDmQBJG8EZx5WzfN-wRlLgTWUMGLmvLKYNrZirwTUKU9Iwq9gFerH4DjH8nCCNuvPJQtuaHsKUtJCsVoyI_4JESpUjzI7P_gIPYYp9XkJTymrMpaAnNxtDShGcHqLvTPytCdbzK_Tyigw-ObpNTQf7E3a8fQaeHwGTrGldNL316cQJkfPXM_d04cI0_HvY44U5pDHEW4phLLNeZb1cdJ9G-HWrm_hjvpPkevvtu6bX66_Xn2ilN-wPASyxhg</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Winer, Rachel L.</creator><creator>Kiviat, Nancy B.</creator><creator>Hughes, James P.</creator><creator>Adam, Diane E.</creator><creator>Lee, Shu-Kuang</creator><creator>Kuypers, Jane M.</creator><creator>Koutsky, Laura A.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>Development and Duration of Human Papillomavirus Lesions, after Initial Infection</title><author>Winer, Rachel L. ; Kiviat, Nancy B. ; Hughes, James P. ; Adam, Diane E. ; Lee, Shu-Kuang ; Kuypers, Jane M. ; Koutsky, Laura A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-e52766889fa536e72b653504fc5db3b72e5b4aaea7d4c02b243f9efb8021b3c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsies</topic><topic>Cervical intraepithelial neoplasia</topic><topic>Cervical Intraepithelial Neoplasia - virology</topic><topic>Cervix Uteri - pathology</topic><topic>Cervix Uteri - virology</topic><topic>Condylomata acuminata</topic><topic>Condylomata Acuminata - pathology</topic><topic>Condylomata Acuminata - physiopathology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human papillomavirus</topic><topic>Human papillomavirus 11</topic><topic>Human papillomavirus 16</topic><topic>Human papillomavirus 18</topic><topic>Human papillomavirus 6</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Lesions</topic><topic>Longitudinal Studies</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Papillomaviridae - pathogenicity</topic><topic>Papillomavirus Infections - pathology</topic><topic>Papillomavirus Infections - physiopathology</topic><topic>Time Factors</topic><topic>Uterine Cervical Neoplasms - virology</topic><topic>Virology</topic><topic>Viruses</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Winer, Rachel L.</creatorcontrib><creatorcontrib>Kiviat, Nancy B.</creatorcontrib><creatorcontrib>Hughes, James P.</creatorcontrib><creatorcontrib>Adam, Diane E.</creatorcontrib><creatorcontrib>Lee, Shu-Kuang</creatorcontrib><creatorcontrib>Kuypers, Jane M.</creatorcontrib><creatorcontrib>Koutsky, Laura A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Winer, Rachel L.</au><au>Kiviat, Nancy B.</au><au>Hughes, James P.</au><au>Adam, Diane E.</au><au>Lee, Shu-Kuang</au><au>Kuypers, Jane M.</au><au>Koutsky, Laura A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development and Duration of Human Papillomavirus Lesions, after Initial Infection</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>191</volume><issue>5</issue><spage>731</spage><epage>738</epage><pages>731-738</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>BackgroundTo determine the potential value of human papillomavirus (HPV) vaccines, information concerning the incidence and duration of clinically important lesions is needed MethodsA total of 603 female university students were followed for a mean duration of 38.8 months. Triannual gynecologic examinations included cervical and vulvovaginal specimen collection for Pap and HPV DNA testing. Women with cytologic evidence of a high-grade squamous intraepithelial lesion (SIL) were referred for colposcopically directed biopsy ResultsAmong women with incident HPV infection, the 36-month cumulative incidence of cervical SILs found by cytologic testing (47.2%; 95% confidence interval [CI], 38.9%–56.4%) was higher than that of vaginal SILs (28.8%; 95% CI, 21.3%–38.2%). The median time to clearance of cervical and vaginal SILs was 5.5 and 4.7 months, respectively. Among women with incident HPV-16 or HPV-18 infection, the 36-month cumulative incidence of cervical intraepithelial neoplasia (CIN) grade 2 was 20.0% (95% CI, 10.8%–35.1%), and that of CIN grade 3 was 6.7% (95% CI, 2.5%–17.0%). The 36-month cumulative incidence of clinically ascertained genital warts among women with incident HPV-6 or HPV-11 infection was 64.2% (95% CI, 50.7%–77.4%) ConclusionsIntraepithelial lesions are common early events among women with incident HPV infection, and the interval between incident HPV-16 or HPV-18 infection and biopsy-confirmed CIN grade 2–3 appears to be relatively short</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>15688287</pmid><doi>10.1086/427557</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Biological and medical sciences Biopsies Cervical intraepithelial neoplasia Cervical Intraepithelial Neoplasia - virology Cervix Uteri - pathology Cervix Uteri - virology Condylomata acuminata Condylomata Acuminata - pathology Condylomata Acuminata - physiopathology Female Fundamental and applied biological sciences. Psychology Human papillomavirus Human papillomavirus 11 Human papillomavirus 16 Human papillomavirus 18 Human papillomavirus 6 Humans Infections Infectious diseases Lesions Longitudinal Studies Medical sciences Microbiology Miscellaneous Papillomaviridae - pathogenicity Papillomavirus Infections - pathology Papillomavirus Infections - physiopathology Time Factors Uterine Cervical Neoplasms - virology Virology Viruses Women |
| title | Development and Duration of Human Papillomavirus Lesions, after Initial Infection |
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