Inhibition of Human Lanosterol Synthase by the Constituents of Colocasia esculenta (Taro)

Ethanol extracts of lyophilized vegetables were tested for inhibition of human lanosterol synthase (hOSC) in order to find the compounds to suppress cholesterol biosynthesis. Of 130 samples tested, twelve samples showed significant inhibition. Among them, Colocasia esculenta (taro) showed the highes...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2005, Vol.28(2), pp.299-304
Hauptverfasser:	Sakano, Yuichi, Mutsuga, Motoh, Tanaka, Rie, Suganuma, Hiroyuki, Inakuma, Takahiro, Toyoda, Masatake, Goda, Yukihiro, Shibuya, Masaaki, Ebizuka, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	cholesterol biosynthesis Colocasia Colocasia esculenta digalactosyldiacylglycerol Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Humans Intramolecular Transferases - antagonists & inhibitors Intramolecular Transferases - metabolism lanosterol synthase monogalactosyldiacylglycerol Plant Extracts - isolation & purification Plant Extracts - pharmacology
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