Epithelial Tight Junctions in Intestinal Inflammation

The epithelium in inflamed intestinal segments of patients with Crohn's disease is characterized by a reduction of tight junction strands, strand breaks, and alterations of tight junction protein content and composition. In ulcerative colitis, epithelial leaks appear early due to micro‐erosions...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2009-05, Vol.1165 (1), p.294-300
Hauptverfasser:	Schulzke, Joerg D., Ploeger, Svenja, Amasheh, Maren, Fromm, Anja, Zeissig, Sebastian, Troeger, Hanno, Richter, Jan, Bojarski, Christian, Schumann, Michael, Fromm, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis barrier function claudins Colitis, Ulcerative - metabolism Crohn Disease - metabolism Crohn's disease Epithelium - metabolism Humans inflammatory bowel disease Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - pathology interleukin-13 Interleukin-13 - metabolism Intestinal Mucosa - metabolism Intestinal Mucosa - pathology tight junction Tight Junctions - metabolism tumor necrosis factor-α ulcerative colitis
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