Overexpression of Nd1-s, a variant form of new kelch family protein, perturbs the cell cycle progression of fibroblasts
The murine Nd1 gene encodes two forms of protein, Nd1-L and Nd1-S, both of which share the BTB/POZ domain, but Nd1-S lacks the kelch repeats. Although Nd1-L ubiquitously expresses, localizes in the cytoplasm and functions as a stabilizer of actin filaments, expression and function of Nd1-S were unkn...
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| Veröffentlicht in: | DNA and cell biology 2005-01, Vol.24 (1), p.30-34 |
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| container_title | DNA and cell biology |
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| creator | Inoue, Atsushi Kang, Myengmo Fujimura, Lisa Takamori, Yasuyuki Sasagawa, Kazushi Itoh, Haruo Tokuhisa, Takeshi Hatano, Masahiko |
| description | The murine Nd1 gene encodes two forms of protein, Nd1-L and Nd1-S, both of which share the BTB/POZ domain, but Nd1-S lacks the kelch repeats. Although Nd1-L ubiquitously expresses, localizes in the cytoplasm and functions as a stabilizer of actin filaments, expression and function of Nd1-S were unknown. Here we show that Nd1-S were expressed in all tissues examined and localized in the nucleus as a speckled-like pattern. Furthermore, overexpression of Nd1-S perturbed cell growth of NIH3T3 cells at the G1/S phase of the cell cycle. These results suggest that Nd1-S may play a role in cell cycle progression in the nucleus. |
| doi_str_mv | 10.1089/dna.2005.24.30 |
| format | Article |
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| subjects | Animals Cell Cycle Cell Nucleus - chemistry Cell Proliferation Fibroblasts - cytology Gene Expression Mice NIH 3T3 Cells Proteins - genetics Proteins - metabolism Proteins - physiology RNA, Messenger - analysis RNA, Messenger - metabolism Tissue Distribution Transfection |
| title | Overexpression of Nd1-s, a variant form of new kelch family protein, perturbs the cell cycle progression of fibroblasts |
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